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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| E431517-1g |
1g |
现货 ![]() |
| |
| E431517-5g |
5g |
现货 ![]() |
|
| 别名 | E-霉素 |
|---|---|
| 英文别名 | Derimer | Erycin | Skid Gel E | Ermycin | Erythrocin | Kesso-Mycin | erthromycin | Erythromycine | Pantoderm | Akne-Mycin | Ery-B | Sansac | Acnesol | E-Mycin (base) | Eryhexal | Iloticina | Endoeritrin | Erycinum | Mephamycin | Pantodrin | Abomacetin | A |
| 规格或纯度 | Moligand™, BioReagent, 用于细胞培养 |
| 英文名称 | Erythromycin |
| 生化机理 | 作用机制: 红霉素通过在转肽步骤中抑制延伸起作用,特别是通过结合细菌70S rRNA复合物的50S亚单位来抑制氨酰从A位点到P位点的易位。 抗菌谱:该产品可以抗革兰氏阴性和革兰氏阳性细菌。 |
| 备注 | 注意: This product is stable in solution at 37°C for 3 days. Stock solutions should be stored at 2-8°C. |
| 产品介绍 |
制备说明 This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light. Gene Information human ... ABCB1(5243), CYP3A4(1576), MLNR(2862)mouse ... Abcb1a(18671), Abcb1b(18669) General Description Chemical structure: macrolide Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus . This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains. Application Erythromycin has been used: as a supplement for nutrient broth medium for culturing green fluorescent protein (GFP)- expressing E. coli as a model drug to determine small intestinal (SMI) microtissue viability using the MTT assay{254 as an antibiotic to study the treatment strategies of chronic infections |
| ALogP | 2.7 |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| PubChem SID | 504752366 |
|---|---|
| EC号 | 204-040-1 |
| 分子类型 | 小分子 |
| IIUPAC Name | (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione |
| INCHI | 1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1 |
| InChi Key | ULGZDMOVFRHVEP-RWJQBGPGSA-N |
| Smiles | CC[C@H]1OC(=O)[C@H](C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)C(C)C(OC3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)C(O)[C@]1(C)O |
| Isomeric SMILES | CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)O)(C)O |
| 分子量 | 733.93 |
| Beilstein号 | 75279 |
| 溶解性 | 2 M HCl:50mg/mL(原液应在 2-8°C 下储存。在 37°C 下可稳定保存 3 天。);乙醇:可溶(原液应在 2-8°C 下储存。在 37°C 下可稳定保存 3 天。) |
|---|---|
| 比旋光度 | -74 ° (C=2, EtOH) |
| 熔点 | 138-140°C |
| 分子量 | 733.900 g/mol |
| XLogP3 | 2.700 |
| 氢键供体数Hydrogen Bond Donor Count | 5 |
| 氢键受体数Hydrogen Bond Acceptor Count | 14 |
| 可旋转键计数Rotatable Bond Count | 7 |
| 精确质量Exact Mass | 733.461 Da |
| 单同位素质量Monoisotopic Mass | 733.461 Da |
| 拓扑极表面积Topological Polar Surface Area | 194.000 Ų |
| 重原子数Heavy Atom Count | 51 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 1180.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 18 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07, GHS08 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H317: 可能引起皮肤过敏反应 H319: 引起严重眼睛刺激 H334: 吸入可能引起过敏或哮喘病症状或呼吸困难 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P272: 被污染的工作服不允许离开工作场所 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P284: 如果通风不良,请佩戴呼吸防护装置。 P321: 特殊处理(请参阅此标签上的...)。 P302+P352: 如皮肤沾染:用水充分清洗。 P304+P340: 如误吸入:将人转移到空气新鲜处,保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。 P333+P313: 如发生皮肤刺激或皮疹:求医/就诊。 P362+P364: 脱掉沾污的衣服,清洗后方可重新使用。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续:寻求医疗帮助。 P342+P316: 如果出现呼吸道症状:立即寻求急救。 |
| WGK Germany | 3 |
| RTECS | KF437500 |
| Merck Index | 3681 |
| 个人防护装备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
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