基本描述

英文别名	E-Mycin \| no
规格或纯度	Moligand™, 10mM in DMSO
英文名称	Erythromycin
生化机理	红霉素（E-Mycin）是一种大环内酯类抗生素，其抗菌谱与青霉素相似或稍宽（IC50=1.5 μg/ml）。
储存温度	-80℃储存
运输条件	超低温冰袋运输
产品介绍	Erythromycin is a potent macrolide inhibitor of CYP3A4 with antiinflammatory and prokinetic properties. Macrolides belong to a group of antibiotics that bind to the 50S ribosomal subunit and inhibit protein synthesis. Erythromycin is derived from Streptomyces erythreus and has been shown to inhibit NF-κB transcriptional activation, which leads to the inhibition of cytokine gene expression of IL-8 and lL-6. This mechanism was shown to occur via calcineruin-independent signaling T lymphocytes. A macrolide antibiotic protein synthesis inhibitor. Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjμgate secretion in human airways in vitro, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains. Information Erythromycin (E-Mycin) is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin (IC50=1.5 μg/ml). In vitro In vivo Cell Data cell lines：U87MG cells Concentrations： Incubation Time： Powder Purity:≥95%

产品属性

ALogP	2.7

关联靶点（人）

CYP3A4 Tclin 细胞色素P450 3A4(Cytochrome P450 3A4) (1 活性数据)

点击查看靶蛋白信息： CYP3A4

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

KCNH2 Tclin 钾电压门控通道亚家族 H 成员 2(Potassium voltage-gated channel subfamily H member 2) (1 活性数据)

点击查看靶蛋白信息： KCNH2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

MLNR Tchem 胃动素受体(Motilin receptor) (4 活性数据)

点击查看靶蛋白信息： MLNR

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

名称和识别符

EC号	204-040-1
分子类型	小分子
Isomeric SMILES	CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)O)(C)O
分子量	733.93
Beilstein号	75279

化学和物理性质

比旋光度	-74 ° (C=2, EtOH)
熔点	138-140°C

安全和危险性（GHS）

WGK Germany	3
RTECS	KF437500
Merck Index	3681
个人防护装备	Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

技术文档和文章

抗生素阻断细菌蛋白合成

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抗生素四环素类抗生素氨基糖苷类抗生素大环内酯类抗生素肽基转移酶抑制剂细胞培养用抗生素

此产品的引用文献

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引用文献

1. Ben-Qing Huang, Hong-Guang Cui, Tian-Yun Feng, Cai-Ling Yuan, Ai-Lian Chang, Ming-Lu Shao, Chi-Fan Zhu. (2024) Thin film composite polyamide nanofiltration membranes with interlayer constructed with core-shell structured polystyrene-polyacrylamide nanospheres for antibiotics separation. Journal of Water Process Engineering, 57 (104550). [10.1016/j.jwpe.2023.104550]
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6. Xiaoyu Zhang, Peiran Meng, Wei Wang, Xiwen Li, Zuan Yang, Shaokai Du, Yue Sun. (2023) Simultaneous Electrochemical Determination of Erythromycin and Hemoglobin by Flexible Carbon Cloth Modified with ZnO Nanorod Arrays and Au Nanoparticles by Differential Pulse Voltammetry (DPV). ANALYTICAL LETTERS, [10.1080/00032719.2023.2292664]
7. Mingjiao Shi, Peizheng Shi, Xinxin Yang, Ningbin Zhao, Mengfan Wu, Jing Li, Chen Ye, He Li, Nan Jiang, Xiufen Li, Guosong Lai, Wan-Feng Xie, Li Fu, Gang Wang, Yangguang Zhu, Hsu-Sheng Tsai, Cheng-Te Lin. (2023) A promising electrochemical sensor based on PVP-induced shape control of a hydrothermally synthesized layered structured vanadium disulfide for the sensitive detection of a sulfamethoxazole antibiotic. ANALYST, [PMID:38050732] [10.1039/D3AN01355C]
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11. Nan Li, Juan Zheng, Lu-Dan Yu, Yuan-Jun Tong, Xinying Gong, Yu Hou, Guosheng Chen, Jianqiao Xu, Fang Zhu, Gangfeng Ouyang. (2024) Green, mildly synthesized bismuth-based MOF for extraction of polar glucocorticoids in environmental water. JOURNAL OF HAZARDOUS MATERIALS, 461 (132477). [PMID:37716268] [10.1016/j.jhazmat.2023.132477]
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20. Cheng-Yu Wu, Chen-Ying Wang, Gui-Jin Sun, Ying-Qiu Li, Yan Liang, Dong-Liang Hua, Lei Chen, Hai-Zhen Mo. (2023) Antibacterial characteristics of allyl methyl disulfide and dimethyl trisulfide of Allium tenuissimum flower essential oil against Escherichia coli O157:H7. INDUSTRIAL CROPS AND PRODUCTS, 202 (117058). [10.1016/j.indcrop.2023.117058]
21. Huafang Zhang, Qinghong Pan, Wanying Cai, Xiaowei Shi, Da-Peng Yang, Hetong Lin, Enhui Qiu. (2023) C-doped ZnO nanocomposites molecularly imprinted photoelectrochemical sensor for ultrasensitive and selective detection of oxytetracycline in milk. FOOD CHEMISTRY, 426 (136535). [PMID:37331139] [10.1016/j.foodchem.2023.136535]
22. Junyang Pan, Dan Hua, Yiping Hong, Xi Cheng, Fangsong Guo, Kok Bing Tan, Ziqi Zhong, Guowu Zhan. (2023) Design of hybrid g-C3N4/GO/MCE photocatalytic membranes with enhanced separation performance under visible-light irradiation. CHEMICAL ENGINEERING JOURNAL, 466 (143164). [10.1016/j.cej.2023.143164]
23. Ping Zhang, Yuchi Zhang, Xianliang Li, Yan Xu. (2023) Radial mesoporous silica supported Eu3+-functionalized carbon dots for ratiometric tetracycline detection and their polyvinylidene fluoride hybrid film for temperature sensing. APPLIED ORGANOMETALLIC CHEMISTRY, 37 (6): (e7096). [10.1002/aoc.7096]
24. Bingzhang Li, Yao Meng, Xiaoxia Lin, Degui Tu, Shunxi Shen, Ting He, Yuqi Li, Hui Zhang. (2023) Enhanced photo-electro-Fenton degradation performance using graphene structure-oriented MOFs (2Fe/Co)/CNF cathode membrane. Journal of Cleaner Production, 401 (136782). [10.1016/j.jclepro.2023.136782]
25. Yunyan Ren, Zhefeng Fan. (2023) Synthesis of fluorescent probe based on molecularly imprinted polymers on nitrogen-doped carbon dots for determination of tobramycin in milk. FOOD CHEMISTRY, 416 (135792). [PMID:36878117] [10.1016/j.foodchem.2023.135792]
26. Yuan Xie, Fanping Kong, Zhiwei Mi, Hanhan Huang, Caifeng Xia, Zequn Ma, Shuang Li, Qian Zhang, Zilin Meng. (2023) High-efficiency removal of antibiotics through self-assembly formation of layered double hydroxides in wastewater. Journal of Water Process Engineering, 52 (103502). [10.1016/j.jwpe.2023.103502]
27. Yao Jun, Zeng Xiang. (2023) Photoelectrochemical biosensor based on DNA aptamers and dual nano-semiconductor heterojunctions for accurate and selective sensing of chloramphenicol. MICROCHIMICA ACTA, 190 (1): (1-11). [PMID:36495321] [10.1007/s00604-022-05573-2]
28. Zong-Ying Li, Hong-Xia Zhang, Tian-Sheng He, Hong-Xin Jiang, Xiao-Wei Liu, Li-Na Zhu, Xiao-Zeng Li, De-Ming Kong. (2023) A multifunctional and water-stable Cd (II) coordination polymer: Sensitive detection of roxarsone, Fe3+, CrO42− and Cr2O72− in aqueous media. INORGANICA CHIMICA ACTA, 547 (121334). [10.1016/j.ica.2022.121334]
29. Ludan Qin, Shuo Yao, Wenqing Meng, Jiajia Zhang, Ruirui Shi, Chuanjian Zhou, Junling Wu. (2022) Novel antibacterial dental resin containing silanized hydroxyapatite nanofibers with remineralization capability. DENTAL MATERIALS, 38 (1989). [PMID:36424206] [10.1016/j.dental.2022.11.014]
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31. Jingyu Wang, Dezhe Fan, Lizhu Zhang, Dongjie Yang, Xueqing Qiu, Xuliang Lin. (2023) Lignin-derived hierarchical porous carbon with high surface area and interconnected pores for efficient antibiotics adsorption. CHEMICAL ENGINEERING JOURNAL, 454 (139789). [10.1016/j.cej.2022.139789]
32. Sizhan Wu, Hangdao Qin, Hao Cheng, Wei Shi, Jing Chen, Jiming Huang, Hui Li. (2022) A novel MnFe2O4-HSO3 nanocatalyst for heterogeneous Fenton degradation of antibiotics. CATALYSIS COMMUNICATIONS, 171 (106522). [10.1016/j.catcom.2022.106522]
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34. Xinyi Deng, Sizhe Zhang, Nengsheng Ye, Lu Zhang, Yuhong Xiang. (2022) Ratiometric fluorescence for ultrasensitive detection of chlortetracycline in milk matrix based on its blue alkaline degradation product and red-emitting cyclodextrin stabilized gold nanocluster. DYES AND PIGMENTS, 206 (110660). [10.1016/j.dyepig.2022.110660]
35. Liang Ren, Jianxin Chen, Qing Lu, Jian Han, Jinsheng Liang, Hong Wu. (2022) Cucurbit[n]uril-rotaxanes functionalized membranes with heterogeneous channel and regenerable surface for efficient and sustainable nanofiltration. JOURNAL OF MEMBRANE SCIENCE, 659 (120765). [10.1016/j.memsci.2022.120765]
36. Ruihong Yao, Zhijian Li, Panpan Huo, Congcong Gong, Gang Liu, Chunhong Zheng, Shouzhi Pu. (2022) L-histidine functionalized ZiF-8 with aggregation-induced emission for detection of tetracycline. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 280 (121546). [PMID:35759934] [10.1016/j.saa.2022.121546]
37. Zhijing Wu, Yu Zhang, Gang Nie, Junxi Liu, Hao Mei, Zihao He, Pengfei Dou, Kaiping Wang. (2022) Tracking the gastrointestinal digestive and metabolic behaviour of Dendrobium officinale polysaccharides by fluorescent labelling. Food & Function, 13 (13): (7274-7286). [PMID:35726749] [10.1039/D2FO01506D]
38. Xinlei Zhang, Peng Liu, Bohan Li, Xianliang Li, Yan Xu. (2022) Hydrogen bonding-mediated assembly of carbon dot@Zr-based metal organic framework as a multifunctional fluorescence sensor for chlortetracycline, pH and temperature detection. NEW JOURNAL OF CHEMISTRY, 46 (27): (13021-13029). [10.1039/D2NJ02244C]
39. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin. (2022) The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics. MOLECULAR & CELLULAR PROTEOMICS, 21 (9): [PMID:35605723] [10.1016/j.mcpro.2022.100248]
40. Guiqiu Li, Ying Wei, Yan Guo, Hui Gong, Jie Lian, Guangjian Xu, Bing Bai, Zhijian Yu, Qiwen Deng. (2022) Omadacycline Efficacy against Streptococcus Agalactiae Isolated in China: Correlation between Resistance and Virulence Gene and Biofilm Formation. Computational Intelligence and Neuroscience, 2022 (7636983). [PMID:35510054] [10.1155/2022/7636983]
41. Wang Yang, Jin Daobin, Zhang Xiaoqian, Zhao Jikuan, Hun Xu. (2022) Self-enhancement photoelectrochemical strategy for kanamycin determination with amino functionalized MOFs. MICROCHIMICA ACTA, 189 (5): (1-7). [PMID:35426050] [10.1007/s00604-022-05266-w]
42. Dingmin Liu, Pengcheng Huang, Fang-Ying Wu. (2022) Colorimetric determination of tetracyclines based on aptamer-mediated dual regulation of gold nanoparticle aggregation and in situ silver metallization. Analytical Methods, 14 (18): (1803-1809). [PMID:35481598] [10.1039/D2AY00368F]
43. Wensong Zou, Jing Li, Ranhao Wang, Jingyi Ma, Zhijie Chen, Lele Duan, Hongwei Mi, Hong Chen. (2022) Hydroxylamine mediated Fenton-like interfacial reaction dynamics on sea urchin-like catalyst derived from spent LiFePO4 battery. JOURNAL OF HAZARDOUS MATERIALS, 431 (128590). [PMID:35247735] [10.1016/j.jhazmat.2022.128590]
44. Yu-Hua Liu, Li-Ju Tan, Kun-Peng Wang, Jiang-Tao Wang. (2022) Rapid detection of ciprofloxacin in seawater based on CdTe quantum dots coated with molecularly imprinted polymers. INTERNATIONAL JOURNAL OF MODERN PHYSICS B, [10.1142/S0217979222400124]
45. Ying Wang, Song Zhao, Zhiyuan Zha, Zhi Wang, Jixiao Wang. (2022) Host-guest nanofiltration membranes having amino-complexed cucurbituril supramolecular channel for monovalent/divalent salts separation. DESALINATION, 527 (115582). [10.1016/j.desal.2022.115582]
46. Ou Panpan, Wu Jiawen, Lin Yu, Tan Xuecai, Wu Yeyu, Chen Zhifan, Wei Fucun, Huang Kejing. (2022) Flexible photoelectrochemical sensor for highly sensitive chloramphenicol detection based on M-TiO2-CdTe QDs/CdS QDs composite. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 414 (6): (2065-2078). [PMID:34984509] [10.1007/s00216-021-03840-4]
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59. Xuejian Xing, Li Huang, Shaojing Zhao, Jiafu Xiao, Minhuan Lan. (2020) S,N-Doped carbon dots for tetracyclines sensing with a fluorometric spectral response. MICROCHEMICAL JOURNAL, 157 (105065). [10.1016/j.microc.2020.105065]
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