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薯蓣皂素

甾体皂苷。凋亡和抗氧化剂。
14篇引用文献 COA COA
    级别和纯度:
  • ≥95%
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货号 (SKU) 包装规格 是否现货 价格 数量
D101265-1g
 1g 现货 Stock Image
D101265-5g
 5g 现货 Stock Image
D101265-25g
 25g 现货 Stock Image
D101265-100g
 100g 现货 Stock Image
D101265-500g
 500g 期货 Stock Image
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查看相关系列
JAK/STAT Signaling (508) MicroRNA (35) Non-coding RNA (34664) STAT (138) Stem Cell/Wnt (1018) 类固醇类 (126) 表观遗传学 (1497)
main product photo

基本描述

别名 地奥配质
英文别名 (3beta,25R)-spirost-5-en-3-ol | AKOS015961083 | DIOSGENIN | (25R)-5-Spirosten-3A-ol | K49P2K8WLX | MFCD00016887 | DIOSGENIN [MI] | (1'S,2R,2'S,4'S,5R,7'S,8'R,9'S,12'S,13'R,16'S)-5,7',9',13'-tetramethyl-5'-oxaspiro[oxane-2,6'-pentacyclo[10.8.0.0^{2,9}.0^{4
规格或纯度 ≥95%
英文名称 Diosgenine
生化机理 甾体皂苷。凋亡和抗氧化剂。以HIF-1α依赖性机制促进血管生成。在体内显示出抗癌和免疫抑制作用。抑制STAT3，PI3K，Akt，ERK和JNK磷酸化和促炎细胞因子产物
运输条件 常规运输
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

Diosgenine is a steroid sapogenin used in the semi-synthesis of pregnenolone, cortisone, and progesterone. Diosgenin has estrogenic activity and can reduce the level of serum cholesterol.A steroid sapogenin with estrogenic activity

Diosgenine is a steroid sapogenin used in the semi-synthesis of pregnenolone, cortisone, and progesterone. Diosgenin has estrogenic activity and can reduce the level of serum cholesterol.
A steroid sapogenin with estrogenic activity
纯度 ≥95%

关联靶点（人）

STAT3 Tchem Signal transducer and activator of transcription 3 (3313 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
UGT1A4 Tbio UDP-glucuronosyltransferase 1A4 (288 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
BXPC-3 (2997 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DU-145 (51482 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HL-60 (67320 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HT-29 (80576 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Huh-7 (12904 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
K562 (73714 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MCF7 (126967 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MKN-45 (2102 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MM96L (154 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NCI-H358 (882 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NFF (353 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SH-SY5Y (11521 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SW480 (6023 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
T-24 (2342 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
THP-1 (11052 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
A549 (127892 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HBL-100 (746 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HCT-116 (91556 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HepG2 (196354 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NCI-H460 (60772 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SF-268 (49410 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KM-20L2 (14967 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HeLa (62764 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MDA-MB-231 (73002 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SW-620 (52400 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ASPC1 (1310 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SMMC-7721 (5516 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
UGT1A1 Tchem UDP-glucuronosyltransferase 1-1 (448 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
UGT1A8 Tbio UDP-glucuronosyltransferase 1-8 (233 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
UGT1A3 Tbio UDP-glucuronosyltransferase 1-3 (217 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GES1 (603 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
L02 (4864 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Streptococcus pneumoniae (31063 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Enterobacter cloacae (7976 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Micrococcus luteus (7463 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Neisseria gonorrhoeae (1461 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mycobacterium tuberculosis (203094 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Enterococcus faecalis (29875 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cryptococcus neoformans (21258 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Candida albicans (78123 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Acyrthosiphon pisum (40 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hepatitis C virus (23859 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Stenotrophomonas maltophilia (1743 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
P388 (20296 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RAW (181 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RAW264.7 (28094 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Vero (26788 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 488187181
EC号 208-134-3
分子类型 小分子
IIUPAC Name (1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,16S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-ol
INCHI 1S/C27H42O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28H,6-15H2,1-4H3/t16-,17+,19+,20-,21+,22+,23+,24+,25+,26+,27-/m1/s1
InChi Key WQLVFSAGQJTQCK-VKROHFNGSA-N
Smiles CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)O)C)C)C)OC1
Isomeric SMILES C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC=C6[C@@]5(CC[C@@H](C6)O)C)C)C)OC1
分子量 414.62
Beilstein号 94582
Reaxy-Rn 1296718
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1296718&ln=

化学和物理性质

溶解性 Soluble in chloroform (50 mg/ml), ethanol (83 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), DMSO (<1 mg/ml at 25 °C), and methanol.,
密度 1.13
比旋光度 -126° (C=1,CHCl3)
熔点 205°C
分子量 414.600 g/mol
XLogP3 5.700
氢键供体数Hydrogen Bond Donor Count 1
氢键受体数Hydrogen Bond Acceptor Count 3
可旋转键计数Rotatable Bond Count 0
精确质量Exact Mass 414.313 Da
单同位素质量Monoisotopic Mass 414.313 Da
拓扑极表面积Topological Polar Surface Area 38.700 Ų
重原子数Heavy Atom Count 30
形式电荷Formal Charge 0
复杂度Complexity 746.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 11
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

WGK Germany 2
Merck Index 3295
个人防护装备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

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批号(Lot Number) 证书类型 货号
H2522791 分析证书 D101265
H2512135 分析证书 D101265
J1726060 分析证书 D101265
G2114051 分析证书 D101265
A2521008 分析证书 D101265
A2521015 分析证书 D101265
D1621022 分析证书 D101265
L2206637 分析证书 D101265
L2206671 分析证书 D101265
L2206678 分析证书 D101265
L2206682 分析证书 D101265
C2330938 分析证书 D101265
C2330939 分析证书 D101265
C2330941 分析证书 D101265
C2330942 分析证书 D101265

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此产品的引用文献

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引用文献

1. Shen Weiyi, Shao Wentao, Wang Qihan, Wang Bo, Zhao Gang, Gu Aihua, Jiang Zhaoyan, Hu Hai.  (2023)  Dietary diosgenin transcriptionally down-regulated intestinal NPC1L1 expression to prevent cholesterol gallstone formation in mice.  JOURNAL OF BIOMEDICAL SCIENCE,  30  (1): (1-14).  [PMID:37370162] [10.1186/s12929-023-00933-3]
2. Fan Mingxuan, Tang Lingqian, Wang Yihan, Feng Lu, Zhou Hong.  (2023)  Synthesis and characterization of SO3H-functionalized silica solid acid catalyst and application for the production of diosgenin.  JOURNAL OF NANOPARTICLE RESEARCH,  25  (7): (1-15).  [10.1007/s11051-023-05785-4]
3. Mingxuan Fan, Wenxiu Jiang, Lingqian Tang, Mengqi Zhao, Qingrong Cheng, Lu Feng, Hanjun Wu, Zhiquan Pan, Hong Zhou.  (2022)  Efficient alcoholysis of total saponins in D. zingiberensis C. H. Wright with novel magnetic solid acids through a cleaner approach.  INDUSTRIAL CROPS AND PRODUCTS,  188  (115558).  [10.1016/j.indcrop.2022.115558]
4. Yu Wang, Zhi-jian Lin, Jing Huang, Meng-zhen Chu, Xue-li Ding, Wen-jing Li, Qiu-yue Mao, Bing Zhang.  (2022)  An integrated study of Shenling Baizhu San against hyperuricemia: Efficacy evaluation, core target identification and active component discovery.  JOURNAL OF ETHNOPHARMACOLOGY,  295  (115450).  [PMID:35688256] [10.1016/j.jep.2022.115450]
5. Tang Lingqian, Fan Mingxuan, Pan Zhiquan, Cheng Qingrong, Feng Lu, Wu Hanjun, Zhou Hong.  (2023)  Efficient Alcoholysis of Saponins from Dioscorea zingiberensis by Solid Acids Derived from Diethylenetriamine.  CATALYSIS LETTERS,  153  (4): (1096-1108).  [10.1007/s10562-022-04058-4]
6. Hui Yuan, Xuejun Yu, Wenxiu Jiang, Bowei Shen, Farong Zhang, Zhiquan Pan, Hong Zhou.  (2021)  Polymer-based solid acid catalyst for the green production of diosgenin.  JOURNAL OF APPLIED POLYMER SCIENCE,  139  (6): (51596).  [10.1002/app.51596]
7. Zheng Wan, Huiping Xia, Shiyin Guo, Chaoxi Zeng.  (2021)  Water-in-oil Pickering emulsions stabilized solely by a naturally occurring steroidal sapogenin: Diosgenin.  FOOD RESEARCH INTERNATIONAL,  147  (110573).  [PMID:34399546] [10.1016/j.foodres.2021.110573]
8. Bowei Shen, XueJun Yu, Wenxiu Jiang, Hui Yuan, Mengqi Zhao, Hong Zhou, Zhiquan Pan.  (2021)  Green Conversion of Saponins to Diosgenin in an Alcoholysis System Catalyzed by Solid Acid Derived from Phosphorus Tailings.  ACS Omega,  6  (8): (5423–5435).  [PMID:33681582] [10.1021/acsomega.0c05627]
9. Wenxiu Jiang, Xuejun Yu, Yuan Hui, Bowei Shen, Zhang Farong, Zhiquan Pan, Hong Zhou.  (2021)  Catalytic alcoholysis of saponins in D. zingiberensis C. H. Wright (Curcuma longa L) with magnetic solid acid to prepare diosgenin by response surface methodology.  INDUSTRIAL CROPS AND PRODUCTS,  161  (113197).  [10.1016/j.indcrop.2020.113197]
10. Bowei Shen, XueJun Yu, Farong Zhang, Wenxiu Jiang, Hui Yuan, Zhiquan Pan, Hong Zhou.  (2020)  Green production of diosgenin from alcoholysis of dioscorea zingiberensis C. H. wright by a magnetic solid acid.  Journal of Cleaner Production,  271  (122297).  [10.1016/j.jclepro.2020.122297]
11. Hui Yuan, Xuejun Yu, Bowei Shen, Farong Zhang, Wenxiu Jiang, Zhiquan Pan, Hong Zhou.  (2020)  Preparation of poly (styrene-co-allyl sulfonic acid) as a novel catalyst for the alcoholysis of dioscin.  POLYMERS FOR ADVANCED TECHNOLOGIES,  31  (8): (1776-1782).  [10.1002/pat.4904]
12. Zhang Farong, Shen Bowei, Jiang Wenxiu, Yuan Hui, Zhou Hong.  (2019)  Hydrolysis extraction of diosgenin from Dioscorea nipponica Makino by sulfonated magnetic solid composites.  JOURNAL OF NANOPARTICLE RESEARCH,  21  (12): (1-11).  [10.1007/s11051-019-4702-3]
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14. Qihong Zhang, Xinyu Lin, Weike Su.  (2024)  Study on the components changes of polysaccharides and saponins during nine steaming and drying of Polygonatum sibiricum.  JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,  [PMID:38587108] [10.1002/jsfa.13516]

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