| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| D408362-1ml |
1ml |
现货  |
|
| 英文别名 | Collettiside III, Saponin | β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]- |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Dioscin |
| 生化机理 | Dioscin （Collettiside III，皂苷）是从何首乌（Polygonatum Zanlanscianense Pamp）中提取并分离出来的一种皂苷，具有抗肿瘤活性。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 拮抗剂 |
| 作用机制 | CXCR3 拮抗剂 |
| 产品介绍 |
Information Dioscin (Collettiside III, Saponin) is a saponin extracted and isolated from Polygonatum Zanlanscianense Pamp, showing antitumor activities. Dioscin is extracted and isolated from Polygonatum Zanlanscianense Pamp with IC50 of 2.6, 0.8, 7.5, and 4.5 μM for the inhibition of the growth of the MDA-MB-435, H14, HL60, and HeLa cell lines, respectively. Dioscin induces apotosis in Hela cells by down regulating caspase-8 activity and up regulating caspase-9 activity. In vivo LD50: Mice >300mg/kg cell lines：Mesangial cells Concentrations： Incubation Time： Powder Purity: |
| EC号 | 866-819-8 |
|---|---|
| Isomeric SMILES | C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC=C6[C@@]5(CC[C@@H](C6)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O[C@H]8[C@@H]([C@@H]([C@H]([C@@H](O8)C)O)O)O)O)O[C@H]9[C@@H]([C@@H]([C@H]([C@@H](O9)C)O)O)O)C)C)C)OC1 |
| 关联CAS | 19057-60-4 |
| MeSH Entry Terms | dioscin |
| 分子量 | 869.05 |
| Reaxy-Rn | 42293031 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=42293031&ln= |
| 1. Cao Yongjun, Qiao Nan, Sun Yumeng, Jin Xiaowen, Wen Weibo. (2021) Dioscin alleviates hashimoto’s thyroiditis by regulating the SUMOylation of IRF4 to promote CD4+CD25+Foxp3+ treg cell differentiation. AUTOIMMUNITY, 54 (1): (51-59). [PMID:33274645] [10.1080/08916934.2020.1855428] |
| 2. Qiuyue Ding, Wenda Zhang, Cheng Cheng, Fengbo Mo, Lei Chen, Guangfu Peng, Xianyi Cai, Jinglong Wang, Shuhua Yang, Xianzhe Liu. (2019) Dioscin inhibits the growth of human osteosarcoma by inducing G2/M-phase arrest, apoptosis, and GSDME-dependent cell death in vitro and in vivo. JOURNAL OF CELLULAR PHYSIOLOGY, 235 (3): (2911-2924). [PMID:31535374] [10.1002/jcp.29197] |
| 3. Weixin Zhang, Lianhong Yin, Xufeng Tao, Lina Xu, Lingli Zheng, Xu Han, Youwei Xu, Changyuan Wang, Jinyong Peng. (2016) Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 45 (193). [PMID:27317992] [10.1016/j.etap.2016.06.002] |
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