| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C107691-20mg |
20mg |
现货  |
|
| 别名 | 天然辣椒素 |
|---|---|
| 英文别名 | CAPSAICIN (USP-RS) | 6-Nonenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-, (E)- | N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide | NCGC00017337-02 | N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide | (6E)-N-{[4-hydroxy-3-(methylox |
| 规格或纯度 | Moligand™, 分析标准品, ≥95%(HPLC), 天然 |
| 英文名称 | Capsaicin |
| 生化机理 | 说明：IC50 值：150 ?M （在 FaDu 细胞中进行 MTT 检测）[1]辣椒素是辣椒（辣椒属植物）中的活性成分。辣椒素作为类香草素家族的一员，能与一种称为类香草素受体亚型 1（VR1）的受体结合。辣椒素能在体外导致前列腺癌和肺癌细胞凋亡，从而杀死这些细胞：用辣椒素处理A172细胞可抑制细胞生长，并通过下调Bcl-2和激活caspase-3诱导细胞凋亡。有趣的是，在用辣椒素处理 A172 细胞时，还观察到了协同诱导的形态学变化[2]。加入辣椒素后，活性氧水平在处理的早期阶段略有下降。有趣的是，在 MCF-7 细胞中检测到细胞内钙离子浓度升高[3]。 |
| 应用 | 辣椒的活性成分，辣椒素受体激动剂，神经毒素;激活感觉神经元。 |
| 储存温度 | 2-8°C储存 |
| 运输条件 | 冰袋运输 |
| 作用类型 | 激活剂 |
| 作用机制 | CFTR 激活剂;K v1.1通道阻断剂;K v1.2通道阻断剂;K v1.7通道阻断剂;K v3.1通道阻断剂;TRPV1激活剂 |
| 产品介绍 |
辣椒的活性成分，辣椒素受体激动剂，神经毒素;激活感觉神经元。 |
| 纯度 | ≥95%(HPLC) |
| ALogP | 3.6 |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 206-969-8 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide |
| INCHI | 1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+ |
| InChi Key | YKPUWZUDDOIDPM-SOFGYWHQSA-N |
| Smiles | CC(C)C=CCCCCC(=O)NCC1=CC(=C(C=C1)O)OC |
| Isomeric SMILES | CC(C)/C=C/CCCCC(=O)NCC1=CC(=C(C=C1)O)OC |
| UN Number | 2811 |
| 分子量 | 305.41 |
| Beilstein号 | 2816484 |
| Reaxy-Rn | 2816483 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2816483&ln= |
| 密度 | 1.041 |
|---|---|
| 闪点(℉) | 235.4 °F |
| 闪点(℃) | 113℃ |
| 熔点 | 65°C |
| 分子量 | 305.400 g/mol |
| XLogP3 | 3.600 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 9 |
| 精确质量Exact Mass | 305.199 Da |
| 单同位素质量Monoisotopic Mass | 305.199 Da |
| 拓扑极表面积Topological Polar Surface Area | 58.600 Ų |
| 重原子数Heavy Atom Count | 22 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 341.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 1 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 1 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS05, GHS06, GHS07 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H301: 吞咽会中毒 H315: 引起皮肤刺激 H317: 可能引起皮肤过敏反应 H318: 造成严重的眼睛损伤 H334: 吸入可能引起过敏或哮喘病症状或呼吸困难 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P330: 漱口 P302+P352: 如皮肤沾染：用水充分清洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P305+P354+P338: 如果进入眼睛：立即用水冲洗几分钟。取下隐形眼镜（如果有的话），并且操作简单。继续冲洗。 P317: 寻求紧急医疗救助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 |
| WGK Germany | 3 |
| RTECS | RA8530000 |
| Merck Index | 1768 |
| 个人防护装备 | Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges |
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