货号 (SKU)

包装规格

是否现货

价格

数量

Ab170485-100μg

100μg

现货

Ab170485-1mg

1mg

现货

Ab170485-5mg

5mg

现货

Ab170485-10mg

10mg

期货

基本信息

产品名称	Amatuximab (anti-MSLN), 间皮素抑制剂
别名	阿麦妥单抗 \| 阿马妥昔单抗(抗 MSLN)
英文别名	Amatuximab \| CAK 1 antibody \| CAK1 antibody \| CAK1 antigen antibody \| cleaved form antibody \| Megakaryocyte potentiating factorantibody \| Mesothelin antibody \| Mesothelin isoform 1 precursorantibody \| MPF antibody \| Msln antibody \| MSLN_HUMAN antibody \| P
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	MSLN
应用	ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
种属反应性	人(Human),小鼠(Mouse),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated
作用类型	抑制剂
作用机制	间皮素抑制剂

产品属性

抗体类型	Primary antibody
克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	26.9 kDa (Light Chain) & 51.7 kDa (Heavy Chain), under reducing conditions; 175.6 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
来源	CHO supernatant
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	931402-35-6
分子类型	抗体

关联靶点（人）

MSLN Tbio 间皮素(Mesothelin) (0 活性数据)

点击查看靶蛋白信息： MSLN

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Flow Cytometry: Amatuximab (anti-MSLN) (Ab170485)

Amatuximab (anti-MSLN) (Ab170485) - Flow Cytometry
Flow Cytometry analysis of Hela cells labelling MSLN (red) with Amatuximab (anti-MSLN) (Ab170485). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Amatuximab (anti-MSLN) (Ab170485)

Amatuximab (anti-MSLN) (Ab170485) - SEC
The purity of Amatuximab (anti-MSLN) (Ab170485) is more than 95% verified by HPLC.

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找到5个结果

批号(Lot Number)	证书类型	货号
ZJ23F1101559	分析证书	Ab170485
ZJ23F1101558	分析证书	Ab170485
ZJ24F0911478	分析证书	Ab170485
ZJ24F0911477	分析证书	Ab170485
ZJ24F0911476	分析证书	Ab170485

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引用文献

1. Hassan R, Ebel W, Routhier EL, Patel R, Kline JB, Zhang J, Chao Q, Jacob S, Turchin H, Gibbs L et al.. (2007) Preclinical evaluation of MORAb-009, a chimeric antibody targeting tumor-associated mesothelin.. Cancer Immun, 7 (20). [PMID:18088084]
2. Hassan R, Cohen SJ, Phillips M, Pastan I, Sharon E, Kelly RJ, Schweizer C, Weil S, Laheru D. (2010) Phase I clinical trial of the chimeric anti-mesothelin monoclonal antibody MORAb-009 in patients with mesothelin-expressing cancers.. Clin Cancer Res, 16 (24): (6132-8). [PMID:21037025]
3. Tang Z, Qian M, Ho M. (2013) The role of mesothelin in tumor progression and targeted therapy.. Anticancer Agents Med Chem, 13 (2): (276-80). [PMID:22721387]
4. Ma J, Tang WK, Esser L, Pastan I, Xia D. (2012) Characterization of crystals of an antibody-recognition fragment of the cancer differentiation antigen mesothelin in complex with the therapeutic antibody MORAb-009.. Acta Crystallogr Sect F Struct Biol Cryst Commun, 68 (Pt 8): (950-3). [PMID:22869130]
5. Hassan R, Kindler HL, Jahan T, Bazhenova L, Reck M, Thomas A, Pastan I, Parno J, O'Shannessy DJ, Fatato P et al.. (2014) Phase II clinical trial of amatuximab, a chimeric antimesothelin antibody with pemetrexed and cisplatin in advanced unresectable pleural mesothelioma.. Clin Cancer Res, 20 (23): (5927-36). [PMID:25231400]
6. Kojima, T T and 6 more authors.. (1995) Molecular cloning and expression of megakaryocyte potentiating factor cDNA.. The Journal of biological chemistry, (15): [PMID:7665620]
7. Yamaguchi, N N and 5 more authors.. (1994) A novel cytokine exhibiting megakaryocyte potentiating activity from a human pancreatic tumor cell line HPC-Y5.. The Journal of biological chemistry, (14): [PMID:8288629]
8. Chang, K K and Pastan, I I.. (1996) Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers.. Proceedings of the National Academy of Sciences of the United States of America, (9): [PMID:8552591]
9. Scholler, N N and 6 more authors.. (1999) Soluble member(s) of the mesothelin/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma.. Proceedings of the National Academy of Sciences of the United States of America, (28): [PMID:10500211]
10. Daniels, R J RJ and 10 more authors.. (2001) Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.. Human molecular genetics, (15): [PMID:11157797]
11. Rump, Armin A and 6 more authors.. (2004) Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion.. The Journal of biological chemistry, (5): [PMID:14676194]
12. Muminova, Zhanat E ZE, Strong, Theresa V TV and Shaw, Denise R DR.. (2004) Characterization of human mesothelin transcripts in ovarian and pancreatic cancer.. BMC cancer, (12): [PMID:15140265]
13. Martin, Joel J and 121 more authors.. (2004) The sequence and analysis of duplication-rich human chromosome 16.. Nature, (23): [PMID:15616553]
14. Ho, Mitchell M and 6 more authors.. (2005) Humoral immune response to mesothelin in mesothelioma and ovarian cancer patients.. Clinical cancer research : an official journal of the American Association for Cancer Research, (15): [PMID:15897581]
15. Onda, Masanori M and 6 more authors.. (2006) Megakaryocyte potentiation factor cleaved from mesothelin precursor is a useful tumor marker in the serum of patients with mesothelioma.. Clinical cancer research : an official journal of the American Association for Cancer Research, (15): [PMID:16857795]
16. Ma, Jichun J, Tang, Wai Kwan WK, Esser, Lothar L, Pastan, Ira I and Xia, Di D.. (2012) Recognition of mesothelin by the therapeutic antibody MORAb-009: structural and mechanistic insights.. The Journal of biological chemistry, (28): [PMID:22787150]
17. Tagliabracci, Vincent S VS and 14 more authors.. (2015) A Single Kinase Generates the Majority of the Secreted Phosphoproteome.. Cell, (18): [PMID:26091039]

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Amatuximab (anti-MSLN), 间皮素抑制剂

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Amatuximab (anti-MSLN), 间皮素抑制剂

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质检证书（CoA,COO,BSE/TSE 和分析图谱)

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