基本信息

产品名称	Recombinant CD8α Antibody
别名	白细胞分化抗原8 \| CD8抗体 \| 大鼠抗小鼠CD8 alpha \| CD8 alpha抗体
英文别名	alpha polypeptide (p32) antibody \| CD_antigen=CD8a antibody \| CD8 antibody \| CD8 antigen alpha polypeptide antibody \| CD8 antigen alpha polypeptide (p32) antibody \| CD8 antigen, alpha polypeptide (p32) antibody \| CD8a antibody \| CD8A antigen antibody \| CD
规格或纯度	无动物源, 无载体, 重组, ExactAb™, 无叠氮钠, 已验证, 高性能, ≥95%(SDS-PAGE), 见COA
生化机理	Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
宿主种属	大鼠(Rat)
特异性	Mouse CD8α
种属反应性	小鼠(Mouse)
免疫原	Mouse Spleen Cells or Thymocyte Membranes
阳性对照	Flow Cytometry: Mouse Splenocyte
偶联	Unconjugated

产品属性

克隆类型	重组抗体
Format	Whole IgG
SDS-PAGE	150 kDa
纯化方法	Protein A purified
储存缓冲液	PBS, pH 7.4
浓度	见COA
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at 4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
分子类型	抗体

关联靶点（人）

CD8A Tbio T 细胞表面糖蛋白 CD8 α 链(T-cell surface glycoprotein CD8 alpha chain) (0 活性数据)

点击查看靶蛋白信息： CD8A

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

图片

Flow Cytometry: Recombinant CD8 alpha Antibody (Ab210971)

Recombinant CD8 alpha Antibody (Ab210971) - Flow Cytometry
Flow Cytometry analysis of BALB/c mouse splenocytes labelling CD8 alpha with Recombinant CD8 alpha Antibody (Ab210971) conjugated with biotin (right panel) at 0.2 μg/mL for 1 hour at 4°C, compared with Rat IgG (Ab180310) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).

Flow Cytometry: Recombinant CD8 alpha Antibody (Ab210971)

Recombinant CD8 alpha Antibody (Ab210971) - Flow Cytometry
Flow Cytometry analysis of BALB/c mouse splenocytes labelling CD8 alpha (red) with Recombinant CD8 alpha Antibody (Ab210971) conjugated with biotin at 0.2 μg/mL for 1 hour at 4°C, and detected with SA-PE (rp156150). Blue - Isotype control, Rat IgG (Ab180310) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.