货号 (SKU)

包装规格

是否现货

价格

数量

Ab177877-100μg

100μg

现货

Ab177877-1mg

1mg

现货

Ab177877-5mg

5mg

现货

Ab177877-10mg

10mg

期货

基本信息

产品名称	BHQ880 (anti-DKK1)
别名	Dickkopf 1 antibody \| Dickkopf 1 homolog antibody \| Dickkopf 1 like antibody \| Dickkopf homolog 1 antibody \| Dickkopf like protein 1 antibody \| Dickkopf related protein 1 antibody \| Dickkopf WNT signaling pathway inhibitor 1 antibody \| Dickkopf-1 antibody
英文别名	Dickkopf-1 \| Dkk-1 \| hDkk-1 \| SK
规格或纯度	无载体, 重组, ExactAb™, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	DKK1
种属反应性	人(Human),小鼠(Mouse),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	lambda
SDS-PAGE	27.2 kDa (Light Chain) & 49.6 kDa (Heavy Chain), under reducing conditions; 190.3 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95% (SDS-PAGE&SEC)
物理外观	Liquid
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
分子类型	抗体

关联靶点（人）

DKK1 Tchem Dickkopf 相关蛋白 1(Dickkopf-related protein 1) (0 活性数据)

点击查看靶蛋白信息： DKK1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

DKK1 Tchem Dickkopf-related protein 1 (93 活性数据)

点击查看靶蛋白信息： DKK1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Flow Cytometry: BHQ880 (anti-DKK1) (Ab177877)

BHQ880 (anti-DKK1) (Ab177877) - Flow Cytometry
Flow Cytometry analysis of HepG2 cells labelling DKK1 (red) with BHQ880 (anti-DKK1) (Ab177877). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: BHQ880 (anti-DKK1) (Ab177877)

BHQ880 (anti-DKK1) (Ab177877) - SEC
The purity of BHQ880 (anti-DKK1) (Ab177877) is more than 95% verified by HPLC.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到6个结果

批号(Lot Number)	证书类型	货号
ZJ24F1114057	分析证书	Ab177877
ZJ24F1114056	分析证书	Ab177877
ZJ24F1114055	分析证书	Ab177877
ZJ24F0404124	分析证书	Ab177877
ZJ24F0404123	分析证书	Ab177877
ZJ24F0404122	分析证书	Ab177877

可替换产品

引用文献

1. Mpousis S, Thysiadis S, Avramidis N, Katsamakas S, Efthimiopoulos S, Sarli V.. (2016) Synthesis and evaluation of gallocyanine dyes as potential agents for the treatment of Alzheimer's disease and related neurodegenerative tauopathies.. Eur J Med Chem, 108 (28-38). [PMID:26629858] [10.1016/j.ejmech.2015.11.024]
2. Fedi, P P and 7 more authors.. (1999) Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling.. The Journal of biological chemistry, (2): [PMID:10383463]
3. Krupnik, V E VE and 15 more authors.. (1999) Functional and structural diversity of the human Dickkopf gene family.. Gene, (1): [PMID:10570958]
4. Roessler, E E and 5 more authors.. (2000) The genomic structure, chromosome location, and analysis of the human DKK1 head inducer gene as a candidate for holoprosencephaly.. Cytogenetics and cell genetics, [PMID:10965128]
5. Semënov, M V MV and 5 more authors.. (2001) Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.. Current biology : CB, (26): [PMID:11448771]
6. and Niehrs, C C.. (2006) Function and biological roles of the Dickkopf family of Wnt modulators.. Oncogene, (4): [PMID:17143291]
7. Binnerts, Minke E ME and 18 more authors.. (2007) R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6.. Proceedings of the National Academy of Sciences of the United States of America, (11): [PMID:17804805]
8. Murrills, Richard J RJ and 9 more authors.. (2009) A cell-based Dkk1 binding assay reveals roles for extracellular domains of LRP5 in Dkk1 interaction and highlights differences between wild-type and the high bone mass mutant LRP5(G171V).. Journal of cellular biochemistry, (1): [PMID:19746449]
9. Bourhis, Eric E and 8 more authors.. (2010) Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.. The Journal of biological chemistry, (19): [PMID:20093360]
10. Haniu, Mitsuru M and 7 more authors.. (2011) Human Dickkopf-1 (huDKK1) protein: characterization of glycosylation and determination of disulfide linkages in the two cysteine-rich domains.. Protein science : a publication of the Protein Society, [PMID:21805521]
11. Ahn, Victoria E VE and 5 more authors.. (2011) Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6.. Developmental cell, (15): [PMID:22000856]
12. Zebisch, Matthias M, Jackson, Verity A VA, Zhao, Yuguang Y and Jones, E Yvonne EY.. (2016) Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight into Ternary Complex Formation with LRP6 and Dickkopf.. Structure (London, England : 1993), (6): [PMID:27524201]

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BHQ880 (anti-DKK1)

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器

BHQ880 (anti-DKK1)

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关产品

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引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器