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JNJ-69086420 (anti-KLK2)

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human), 食蟹猴(Cynomolgus monkey)
  • 亚型: Human IgG1
  • 偶联: Unconjugated
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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
Ab177875-100μg
100μg 现货 Stock Image
Ab177875-1mg
1mg 现货 Stock Image
Ab177875-5mg
5mg 现货 Stock Image
Ab177875-10mg
10mg 期货 Stock Image

基本信息

产品名称 JNJ-69086420 (anti-KLK2)
别名 JNJ-69086420(抗 KLK2)
英文别名 EC 3.4.21.35 | Glandular kallikrein-1 | hGK-1 | Tissue kallikrein-2
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 KLK2
种属反应性 人(Human),食蟹猴(Cynomolgus monkey)
偶联 Unconjugated

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG1
轻链亚型 kappa
SDS-PAGE 26.5 kDa (Light Chain) & 50.5 kDa (Heavy Chain), under reducing conditions; 181.6 kDa, under non-reducing conditions.
纯化方法 Protein A purified
纯度 >95%
物理外观 Liquid
储存缓冲液 Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
分子类型 抗体

关联靶点(人)

KLK1 Tchem 激肽释放酶-1(Kallikrein-1) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
KLK2 Tchem 激肽释放酶-2(Kallikrein-2) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
KLK2 Tchem Kallikrein 2 (35 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

JNJ-69086420 (anti-KLK2) (Ab177875) - SEC
The purity of JNJ-69086420 (anti-KLK2) (Ab177875) is more than 95% verified by HPLC.

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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找到6个结果

批号(Lot Number) 证书类型 货号
ZJ25F0420893 分析证书 Ab177875
ZJ25F0420892 分析证书 Ab177875
ZJ25F0420891 分析证书 Ab177875
ZJ24F0405075 分析证书 Ab177875
ZJ24F0405074 分析证书 Ab177875
ZJ24F0405073 分析证书 Ab177875

引用文献

1. Pakkala M, Hekim C, Soininen P, Leinonen J, Koistinen H, Weisell J, Stenman UH, Vepsäläinen J, Närvänen A.  (2007)  Activity and stability of human kallikrein-2-specific linear and cyclic peptide inhibitors..  J Pept Sci,  13  (5): (348-53).  [PMID:17436344]
2. Hekim C, Leinonen J, Närvänen A, Koistinen H, Zhu L, Koivunen E, Väisänen V, Stenman UH.  (2006)  Novel peptide inhibitors of human kallikrein 2..  J Biol Chem,  281  (18): (12555-60).  [PMID:16527822]
3. Santos JA, Kondo MY, Freitas RF, dos Santos MH, Ramalho TC, Assis DM, Juliano L, Juliano MA, Puzer L..  (2016)  The natural flavone fukugetin as a mixed-type inhibitor for human tissue kallikreins..  Bioorg Med Chem Lett,  26  (5): (1485-1489).  [PMID:26848109] [10.1016/j.bmcl.2016.01.039]
4. Riegman, P H PH, Vlietstra, R J RJ, van der Korput, H A HA, Romijn, J C JC and Trapman, J J..  (1991)  Identification and androgen-regulated expression of two major human glandular kallikrein-1 (hGK-1) mRNA species..  Molecular and cellular endocrinology,  [PMID:1726490]
5. Schedlich, L J LJ, Bennetts, B H BH and Morris, B J BJ..  (1987)  Primary structure of a human glandular kallikrein gene..  DNA (Mary Ann Liebert, Inc.),  [PMID:2824146]
6. Liu, X F XF, Essand, M M, Vasmatzis, G G, Lee, B B and Pastan, I I..  (1999)  Identification of three new alternate human kallikrein 2 transcripts: evidence of long transcript and alternative splicing..  Biochemical and biophysical research communications,  (2): [PMID:10544017]
7. Gan, L L and 8 more authors..  (2000)  Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region..  Gene,  (17): [PMID:11054574]
8. Hillman, R Tyler RT, Green, Richard E RE and Brenner, Steven E SE..  (2004)  An unappreciated role for RNA surveillance..  Genome biology,  [PMID:14759258]
9. Cargill, M M and 17 more authors..  (1999)  Characterization of single-nucleotide polymorphisms in coding regions of human genes..  Nature genetics,  [PMID:10391209]

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