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GSK 1070806 (anti-IL-18)

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human), 恒河猴(Rhesus monkey), 食蟹猴(Cynomolgus monkey)
  • 亚型: Human IgG1
  • 偶联: Unconjugated
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库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
Ab177855-100μg
100μg 现货 Stock Image
Ab177855-1mg
1mg 现货 Stock Image
Ab177855-5mg
5mg 现货 Stock Image
Ab177855-10mg
10mg 期货 Stock Image

基本信息

产品名称 GSK 1070806 (anti-IL-18)
别名 GSK 1070806(抗 IL-18)
英文别名 Iboctadekin | IFN-gamma-inducing factor | IL-1 gamma | IL-18 | Interferon gamma-inducing factor | Interleukin-1 gamma
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 IL18
种属反应性 人(Human),恒河猴(Rhesus monkey),食蟹猴(Cynomolgus monkey)
偶联 Unconjugated

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG1
轻链亚型 kappa
SDS-PAGE 26.5 kDa (Light Chain) & 53.7 kDa (Heavy Chain), under reducing conditions; 189.6 kDa, under non-reducing conditions.
纯化方法 Protein A purified
纯度 >95%
物理外观 Liquid
储存缓冲液 Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
分子类型 抗体

关联靶点(人)

IL18 Tbio 白细胞介素-18(Interleukin-18) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

GSK 1070806 (anti-IL-18) (Ab177855) - ELISA
Immobilized Recombinant Human IL-18 Protein (rp147444) at 2.0 μg/mL can bind GSK 1070806 (anti-IL-18) (Ab177855) with the EC₅₀ of 187.6 ng/mL.

GSK 1070806 (anti-IL-18) (Ab177855) - SEC
The purity of GSK 1070806 (anti-IL-18) (Ab177855) is more than 95% verified by HPLC.

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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找到6个结果

批号(Lot Number) 证书类型 货号
ZJ24F1114559 分析证书 Ab177855
ZJ24F1114558 分析证书 Ab177855
ZJ24F1114557 分析证书 Ab177855
ZJ24F0404169 分析证书 Ab177855
ZJ24F0404168 分析证书 Ab177855
ZJ24F0404167 分析证书 Ab177855

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引用文献

1. Ushio, S S and 15 more authors..  (1996)  Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein..  Journal of immunology (Baltimore, Md. : 1950),  (1): [PMID:8666798]
2. Tominaga, K K and 7 more authors..  (2000)  IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells..  International immunology,  [PMID:10653850]
3. Kato, Zenichiro Z and 14 more authors..  (2003)  The structure and binding mode of interleukin-18..  Nature structural biology,  [PMID:14528293]
4. Gaggero, Alessia A and 7 more authors..  (2004)  A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing..  Oncogene,  (30): [PMID:15326478]
5. Jourdan, Tony T and 13 more authors..  (2013)  Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes..  Nature medicine,  [PMID:23955712]
6. Wei, Hui H and 6 more authors..  (2014)  Structural basis for the specific recognition of IL-18 by its alpha receptor..  FEBS letters,  (3): [PMID:25261253]
7. Tsutsumi, Naotaka N and 12 more authors..  (2014)  The structural basis for receptor recognition of human interleukin-18..  Nature communications,  (15): [PMID:25500532]

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