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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab177855-100μg |
100μg |
现货 ![]() |
| |
| Ab177855-1mg |
1mg |
现货 ![]() |
| |
| Ab177855-5mg |
5mg |
现货 ![]() |
| |
| Ab177855-10mg |
10mg |
期货 ![]() |
|
| 产品名称 | GSK 1070806 (anti-IL-18) |
|---|---|
| 别名 | GSK 1070806(抗 IL-18) |
| 英文别名 | Iboctadekin | IFN-gamma-inducing factor | IL-1 gamma | IL-18 | Interferon gamma-inducing factor | Interleukin-1 gamma |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA |
| 宿主种属 | 人(Human) |
| 特异性 | IL18 |
| 种属反应性 | 人(Human),恒河猴(Rhesus monkey),食蟹猴(Cynomolgus monkey) |
| 偶联 | Unconjugated |
| 克隆类型 | 重组抗体 |
|---|---|
| Format | Whole IgG |
| 亚型 | Human IgG1 |
| 轻链亚型 | kappa |
| SDS-PAGE | 26.5 kDa (Light Chain) & 53.7 kDa (Heavy Chain), under reducing conditions; 189.6 kDa, under non-reducing conditions. |
| 纯化方法 | Protein A purified |
| 纯度 | >95% |
| 物理外观 | Liquid |
| 储存缓冲液 | Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | 见COA |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。 |
| 分子类型 | 抗体 |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
GSK 1070806 (anti-IL-18) (Ab177855) - ELISA
Immobilized Recombinant Human IL-18 Protein (rp147444) at 2.0 μg/mL can bind GSK 1070806 (anti-IL-18) (Ab177855) with the EC₅₀ of 187.6 ng/mL.
GSK 1070806 (anti-IL-18) (Ab177855) - SEC
The purity of GSK 1070806 (anti-IL-18) (Ab177855) is more than 95% verified by HPLC.
通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | Ab177855 | |
| 分析证书 | Ab177855 | |
| 分析证书 | Ab177855 | |
| 分析证书 | Ab177855 | |
| 分析证书 | Ab177855 | |
| 分析证书 | Ab177855 |
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| 1. Ushio, S S and 15 more authors.. (1996) Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:8666798] |
| 2. Tominaga, K K and 7 more authors.. (2000) IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells.. International immunology, [PMID:10653850] |
| 3. Kato, Zenichiro Z and 14 more authors.. (2003) The structure and binding mode of interleukin-18.. Nature structural biology, [PMID:14528293] |
| 4. Gaggero, Alessia A and 7 more authors.. (2004) A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing.. Oncogene, (30): [PMID:15326478] |
| 5. Jourdan, Tony T and 13 more authors.. (2013) Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.. Nature medicine, [PMID:23955712] |
| 6. Wei, Hui H and 6 more authors.. (2014) Structural basis for the specific recognition of IL-18 by its alpha receptor.. FEBS letters, (3): [PMID:25261253] |
| 7. Tsutsumi, Naotaka N and 12 more authors.. (2014) The structural basis for receptor recognition of human interleukin-18.. Nature communications, (15): [PMID:25500532] |