货号 (SKU)

包装规格

是否现货

价格

数量

Ab176610-100μg

100μg

现货

Ab176610-1mg

1mg

现货

Ab176610-5mg

5mg

现货

Ab176610-10mg

10mg

期货

基本信息

产品名称	Itolizumab (anti-CD6), T 细胞分化抗原 CD6 抑制剂
别名	伊利组单抗 \| 艾托利珠单抗 \| 伊托珠单抗(抗 CD6)
英文别名	CD_antigen=CD6 antibody \| CD6 antibody \| CD6 antigen Tp120 antibody \| CD6 molecule antibody \| CD6_HUMAN antibody \| FLJ44171 antibody \| OX52 antibody \| T cell differentiation antigen CD6 antibody \| T-cell differentiation antigen CD6 antibody \| T12 antibody
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	CD6
种属反应性	人(Human),大鼠(Rat),小鼠(Mouse)
偶联	Unconjugated
作用类型	抑制剂
作用机制	T 细胞分化抗原 CD6 抑制剂

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	27.8 kDa (Light Chain) & 50.6 kDa (Heavy Chain), under reducing conditions; 175.2 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	1116433-11-4
分子类型	抗体

关联靶点（人）

CD6 Tbio T细胞分化抗原CD6(T-cell differentiation antigen CD6) (0 活性数据)

点击查看靶蛋白信息： CD6

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Flow Cytometry: Itolizumab (anti-CD6) (Ab176610)

Itolizumab (anti-CD6) (Ab176610) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD6 with Itolizumab (anti-CD6) (Ab176610) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).

Flow Cytometry: Itolizumab (anti-CD6) (Ab176610)

Itolizumab (anti-CD6) (Ab176610) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD6 (red) with Itolizumab (anti-CD6) (Ab176610) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Itolizumab (anti-CD6) (Ab176610)

Itolizumab (anti-CD6) (Ab176610) - Flow Cytometry
Flow Cytometry analysis of MOLT-4 cells labelling CD6 (red) with Itolizumab (anti-CD6) (Ab176610). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Itolizumab (anti-CD6) (Ab176610)

Itolizumab (anti-CD6) (Ab176610) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling CD6 (red) with Itolizumab (anti-CD6) (Ab176610). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Itolizumab (anti-CD6) (Ab176610)

Itolizumab (anti-CD6) (Ab176610) - SEC
The purity of Itolizumab (anti-CD6) (Ab176610) is more than 95% verified by HPLC.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

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找到5个结果

批号(Lot Number)	证书类型	货号
ZJ23F1202084	分析证书	Ab176610
ZJ23F1202085	分析证书	Ab176610
ZJ24F1214898	分析证书	Ab176610
ZJ24F1214897	分析证书	Ab176610
ZJ24F1214896	分析证书	Ab176610

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引用文献

1. Alonso R, Huerta V, de Leon J, Piedra P, Puchades Y, Guirola O, Chinea G, Montero E. (2008) Towards the definition of a chimpanzee and human conserved CD6 domain 1 epitope recognized by T1 monoclonal antibody.. Hybridoma (Larchmt), 27 (4): (291-301). [PMID:18707547]
2. Aruffo, A A, Melnick, M B MB, Linsley, P S PS and Seed, B B.. (1991) The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins.. The Journal of experimental medicine, (1): [PMID:1919444]
3. Swack, J A JA, Mier, J W JW, Romain, P L PL, Hull, S R SR and Rudd, C E CE.. (1991) Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule.. The Journal of biological chemistry, (15): [PMID:2016320]
4. Wee, S S and 5 more authors.. (1993) Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors.. The Journal of experimental medicine, (1): [PMID:7678115]
5. Bowen, M A MA and 8 more authors.. (1997) Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:9013954]
6. Gimferrer, Idoia I and 8 more authors.. (2004) Relevance of CD6-mediated interactions in T cell activation and proliferation.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:15294938]
7. Zimmerman, Aukje W AW and 5 more authors.. (2006) Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells.. Blood, (15): [PMID:16352806]
8. Hassan, Namir J NJ and 7 more authors.. (2006) CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76.. Molecular and cellular biology, [PMID:16914752]
9. Castro, Mónica A A MA and 11 more authors.. (2007) Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:17371992]
10. Sarrias, Maria-Rosa MR and 10 more authors.. (2007) CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock.. Proceedings of the National Academy of Sciences of the United States of America, (10): [PMID:17601777]
11. Roncagalli, Romain R and 16 more authors.. (2014) Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub.. Nature immunology, [PMID:24584089]
12. Escoda-Ferran, Cristina C and 8 more authors.. (2014) Modulation of CD6 function through interaction with Galectin-1 and -3.. FEBS letters, (25): [PMID:24945728]
13. Chappell, Paul E PE and 8 more authors.. (2015) Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction.. Structure (London, England : 1993), (4): [PMID:26146185]

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Itolizumab (anti-CD6), T 细胞分化抗原 CD6 抑制剂

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质检证书（CoA,COO,BSE/TSE 和分析图谱)

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引用文献

溶液计算器

摩尔浓度计算器

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Itolizumab (anti-CD6), T 细胞分化抗原 CD6 抑制剂

库存信息

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库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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