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Roledumab (anti-RHD), 血型 Rh(D)多肽抑制剂

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human), 恒河猴(Rhesus monkey)
  • 亚型: Human IgG1
  • 偶联: Unconjugated
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货号 (SKU) 包装规格 是否现货 价格 数量
Ab176453-100μg
100μg 现货 Stock Image
Ab176453-1mg
1mg 现货 Stock Image
Ab176453-5mg
5mg 现货 Stock Image
Ab176453-10mg
10mg 期货 Stock Image

基本信息

产品名称 Roledumab (anti-RHD), 血型 Rh(D)多肽抑制剂
别名 罗来度单抗 | 罗地单抗(抗 RHD)
英文别名 Blood group Rh(D) polypeptide antibody | Blood group--Rhesus system D polypeptide antibody | CD240D antibody | D antigen (DCS) antibody | DIIIc antibody | MGC165007 antibody | RH antibody | Rh blood group antigen Evans antibody | Rh blood group D antigen
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 RHD
种属反应性 人(Human),恒河猴(Rhesus monkey)
偶联 Unconjugated
作用类型 抑制剂
作用机制 血型 Rh(D)多肽抑制剂

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG1
轻链亚型 kappa
SDS-PAGE 26.4 kDa (Light Chain) & 51.4 kDa (Heavy Chain), under reducing conditions; 174.1 kDa, under non-reducing conditions.
纯化方法 Protein A purified
纯度 >95%
物理外观 Liquid
储存缓冲液 Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 1174008-79-7
分子类型 抗体

关联靶点(人)

RHD Tbio 血型 Rh(D) 多肽(Blood group Rh(D) polypeptide) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

Roledumab (anti-RHD) (Ab176453) - SEC
The purity of Roledumab (anti-RHD) (Ab176453) is more than 95% verified by HPLC.

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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找到3个结果

批号(Lot Number) 证书类型 货号
ZJ24F0303081 分析证书 Ab176453
ZJ24F0303080 分析证书 Ab176453
ZJ24F0303079 分析证书 Ab176453

引用文献

1. Le Van Kim, C C and 6 more authors..  (1992)  Multiple Rh messenger RNA isoforms are produced by alternative splicing..  Blood,  (15): [PMID:1379850]
2. Le van Kim, C C and 6 more authors..  (1992)  Molecular cloning and primary structure of the human blood group RhD polypeptide..  Proceedings of the National Academy of Sciences of the United States of America,  (15): [PMID:1438298]
3. Colin, Y Y and 5 more authors..  (1991)  Genetic basis of the RhD-positive and RhD-negative blood group polymorphism as determined by Southern analysis..  Blood,  (15): [PMID:1824267]
4. Suyama, K K, Goldstein, J J, Aebersold, R R and Kent, S S..  (1991)  Regarding the size of Rh proteins..  Blood,  (15): [PMID:1898705]
5. Saboori, A M AM, Smith, B L BL and Agre, P P..  (1988)  Polymorphism in the Mr 32,000 Rh protein purified from Rh(D)-positive and -negative erythrocytes..  Proceedings of the National Academy of Sciences of the United States of America,  [PMID:3131772]
6. Bloy, C C and 5 more authors..  (1988)  Determination of the N-terminal sequence of human red cell Rh(D) polypeptide and demonstration that the Rh(D), (c), and (E) antigens are carried by distinct polypeptide chains..  Blood,  [PMID:3135863]
7. Avent, N D ND and 5 more authors..  (1988)  Protein-sequence studies on Rh-related polypeptides suggest the presence of at least two groups of proteins which associate in the human red-cell membrane..  The Biochemical journal,  (15): [PMID:3146980]
8. Huang, C H CH, Reid, M E ME and Chen, Y Y..  (1995)  Identification of a partial internal deletion in the RH locus causing the human erythrocyte D--phenotype..  Blood,  (15): [PMID:7606008]
9. Rouillac, C C, Le Van Kim, C C, Beolet, M M, Cartron, J P JP and Colin, Y Y..  (1995)  Leu110Pro substitution in the RhD polypeptide is responsible for the DVII category blood group phenotype..  American journal of hematology,  [PMID:7741145]
10. Kajii, E E, Umenishi, F F, Iwamoto, S S and Ikemoto, S S..  (1993)  Isolation of a new cDNA clone encoding an Rh polypeptide associated with the Rh blood group system..  Human genetics,  [PMID:7916743]
11. Suyama, K K, Lunn, R R, Haller, S S and Goldstein, J J..  (1994)  Rh(D) antigen expression and isolation of a new Rh(D) cDNA isoform in human erythroleukemic K562 cells..  Blood,  (15): [PMID:8080999]
12. Westhoff, C M CM and Wylie, D E DE..  (1994)  Identification of a new RhD-specific mRNA from K562 cells..  Blood,  (15): [PMID:8180407]
13. Arce, M A MA and 5 more authors..  (1993)  Molecular cloning of RhD cDNA derived from a gene present in RhD-positive, but not RhD-negative individuals..  Blood,  (15): [PMID:8329718]
14. Wagner, F F FF and 5 more authors..  (1999)  Molecular basis of weak D phenotypes..  Blood,  (1): [PMID:9864185]
15. Urbaniak, S J SJ and Greiss, M A MA..  (2000)  RhD haemolytic disease of the fetus and the newborn..  Blood reviews,  [PMID:10805260]
16. Wagner, F F FF and Flegel, W A WA..  (2000)  RHD gene deletion occurred in the Rhesus box..  Blood,  (15): [PMID:10845894]
17. Shao, Chao-Peng CP, Xiong, Wen W and Zhou, Yi-Yan YY..  (2006)  Multiple isoforms excluding normal RhD mRNA detected in Rh blood group Del phenotype with RHD 1227A allele..  Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis,  [PMID:16510313]

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