货号 (SKU)

包装规格

是否现货

价格

数量

Ab176100-100μg

100μg

现货

Ab176100-1mg

1mg

现货

Ab176100-5mg

5mg

现货

Ab176100-10mg

10mg

期货

基本信息

产品名称	Conatumumab (anti-TNFRSF10B), 肿瘤坏死因子受体超家族成员 10B 激动剂的激动剂
别名	可那木单抗 \| 康那妥单抗(抗 TNFRSF10B)
英文别名	Fas like protein antibody \| Apoptosis inducing protein TRICK2A/2B antibody \| Apoptosis inducing receptor TRAIL R2 antibody \| CD262 antibody \| CD262 antigen antibody \| Cytotoxic TRAIL receptor 2 antibody \| Death domain containing receptor for TRAIL/Apo 2L
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	TNFRSF10B
种属反应性	人(Human),小鼠(Mouse),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated
作用类型	激动剂
作用机制	肿瘤坏死因子受体超家族成员 10B 激动剂的激动剂

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	26.0 kDa (Light Chain) & 51.0 kDa (Heavy Chain), under reducing conditions; 172.6 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	896731-82-1
分子类型	抗体

关联靶点（人）

TNFRSF10A Tchem 肿瘤坏死因子受体超家族成员 10A(Tumor necrosis factor receptor superfamily member 10A) (0 活性数据)

点击查看靶蛋白信息： TNFRSF10A

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

TNFRSF10B Tbio 肿瘤坏死因子受体超家族成员 10B(Tumor necrosis factor receptor superfamily member 10B) (0 活性数据)

点击查看靶蛋白信息： TNFRSF10B

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

TNFRSF10A Tchem TRAIL receptor-1 (4 活性数据)

点击查看靶蛋白信息： TNFRSF10A

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Flow Cytometry: Conatumumab (anti-TNFRSF10B) (Ab176100)

Conatumumab (anti-TNFRSF10B) (Ab176100) - Flow Cytometry
Flow Cytometry analysis of HepG2 cells labelling TNFRSF10B (red) with Conatumumab (anti-TNFRSF10B) (Ab176100). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Conatumumab (anti-TNFRSF10B) (Ab176100)

Conatumumab (anti-TNFRSF10B) (Ab176100) - SEC
The purity of Conatumumab (anti-TNFRSF10B) (Ab176100) is more than 95% verified by HPLC.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到6个结果

批号(Lot Number)	证书类型	货号
ZJ23F1001501	分析证书	Ab176100
ZJ23F1001502	分析证书	Ab176100
ZJ24F1012742	分析证书	Ab176100
ZJ24F1012741	分析证书	Ab176100
ZJ24F1012740	分析证书	Ab176100
ZJ24F0607377	分析证书	Ab176100

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引用文献

1. Ohtsuki T, Kikuchi H, Koyano T, Kowithayakorn T, Sakai T, Ishibashi M.. (2009) Death receptor 5 promoter-enhancing compounds isolated from Catimbium speciosum and their enhancement effect on TRAIL-induced apoptosis.. Bioorg Med Chem, 17 (18): (6748-6754). [PMID:19682913] [10.1016/j.bmc.2009.07.041]
2. Kikuchi H, Ohtsuki T, Koyano T, Kowithayakorn T, Sakai T, Ishibashi M.. (2010) Activity of mangosteen xanthones and teleocidin a-2 in death receptor expression enhancement and tumor necrosis factor related apoptosis-inducing ligand assays.. J Nat Prod, 73 (3): (452-455). [PMID:19788289] [10.1021/np900404e]
3. Sheridan, J P JP and 12 more authors.. (1997) Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors.. Science (New York, N.Y.), (8): [PMID:9242611]
4. Screaton, G R GR and 5 more authors.. (1997) TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL.. Current biology : CB, (1): [PMID:9285725]
5. Walczak, H H and 11 more authors.. (1997) TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.. The EMBO journal, (1): [PMID:9311998]
6. MacFarlane, M M and 5 more authors.. (1997) Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL.. The Journal of biological chemistry, (10): [PMID:9325248]
7. Wu, G S GS and 14 more authors.. (1997) KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene.. Nature genetics, [PMID:9326928]
8. Schneider, P P and 5 more authors.. (1997) Characterization of two receptors for TRAIL.. FEBS letters, (27): [PMID:9373179]
9. Chaudhary, P M PM and 5 more authors.. (1997) Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway.. Immunity, [PMID:9430227]
10. Arai, T T and 5 more authors.. (1998) Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas.. Cancer letters, (27): [PMID:10072170]
11. Mongkolsapaya, J J and 6 more authors.. (1999) Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation.. Nature structural biology, [PMID:10542098]
12. Hymowitz, S G SG and 7 more authors.. (1999) Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5.. Molecular cell, [PMID:10549288]
13. Hillman, R Tyler RT, Green, Richard E RE and Brenner, Steven E SE.. (2004) An unappreciated role for RNA surveillance.. Genome biology, [PMID:14759258]
14. Yamaguchi, Hirohito H and Wang, Hong-Gang HG.. (2004) CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells.. The Journal of biological chemistry, (29): [PMID:15322075]
15. Nusbaum, Chad C and 75 more authors.. (2006) DNA sequence and analysis of human chromosome 8.. Nature, (19): [PMID:16421571]
16. Maddipatla, Sreeram S, Hernandez-Ilizaliturri, Francisco J FJ, Knight, Joy J and Czuczman, Myron S MS.. (2007) Augmented antitumor activity against B-cell lymphoma by a combination of monoclonal antibodies targeting TRAIL-R1 and CD20.. Clinical cancer research : an official journal of the American Association for Cancer Research, (1): [PMID:17671142]
17. Sun, M M, Song, L L, Li, Y Y, Zhou, T T and Jope, R S RS.. (2008) Identification of an antiapoptotic protein complex at death receptors.. Cell death and differentiation, [PMID:18846110]
18. Smith, Wendell W and 17 more authors.. (2013) Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses.. Cell host & microbe, (13): [PMID:23498957]
19. Nemčovičová, Ivana; Benedict, Chris A and Zajonc, Dirk M.. (2013) Structure of human cytomegalovirus UL141 binding to TRAIL-R2 reveals novel, non-canonical death receptor interactions.. PLoS pathogens, [PMID:23555243]
20. Newson, Joshua P M and 11 more authors.. (2019) Salmonella Effectors SseK1 and SseK3 Target Death Domain Proteins in the TNF and TRAIL Signaling Pathways.. Molecular & cellular proteomics : MCP, [PMID:30902834]
21. Pan, G G and 5 more authors.. (1997) An antagonist decoy receptor and a death domain-containing receptor for TRAIL.. Science (New York, N.Y.), (8): [PMID:9242610]

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Conatumumab (anti-TNFRSF10B), 肿瘤坏死因子受体超家族成员 10B 激动剂的激动剂

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Conatumumab (anti-TNFRSF10B), 肿瘤坏死因子受体超家族成员 10B 激动剂的激动剂

库存信息

库存信息

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库存信息

基本信息

产品属性

关联靶点（人）

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图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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