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Sibeprenlimab (anti-TNFSF13), 肿瘤坏死因子配体超家族成员 13 抑制剂

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human), 小鼠(Mouse)
  • 亚型: Human IgG2SA
  • 偶联: Unconjugated
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货号 (SKU) 包装规格 是否现货 价格 数量
Ab176084-100μg
100μg 现货 Stock Image
Ab176084-1mg
1mg 现货 Stock Image
Ab176084-5mg
5mg 现货 Stock Image
Ab176084-10mg
10mg 期货 Stock Image

基本信息

产品名称 Sibeprenlimab (anti-TNFSF13), 肿瘤坏死因子配体超家族成员 13 抑制剂
别名 西布瑞林单抗(抗肿瘤坏死因子FSF13)
英文别名 A proliferation-inducing ligand | APRIL | TALL-2 | TNF- and APOL-related leukocyte expressed ligand 2 | TNF-related death ligand 1 | TRDL-1
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 TNFSF13
种属反应性 人(Human),小鼠(Mouse)
偶联 Unconjugated
作用类型 抑制剂
作用机制 肿瘤坏死因子配体超家族成员 13 抑制剂

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG2SA
轻链亚型 kappa
SDS-PAGE 27.4 kDa (Light Chain) & 51.7 kDa (Heavy Chain), under reducing conditions; 175.1 kDa, under non-reducing conditions.
纯化方法 Protein A purified
纯度 >95%
物理外观 Liquid
储存缓冲液 Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 2382896-07-1
分子类型 抗体

关联靶点(人)

TNFSF13 Tbio 肿瘤坏死因子配体超家族成员 13(Tumor necrosis factor ligand superfamily member 13) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

Sibeprenlimab (anti-TNFSF13) (Ab176084) - Flow Cytometry
Flow Cytometry analysis of A549 cells labelling TNFSF13 (red) with Sibeprenlimab (anti-TNFSF13) (Ab176084). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Sibeprenlimab (anti-TNFSF13) (Ab176084) - SEC
The purity of Sibeprenlimab (anti-TNFSF13) (Ab176084) is more than 95% verified by HPLC.

质检证书(CoA,COO,BSE/TSE 和分析图谱)

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找到6个结果

批号(Lot Number) 证书类型 货号
ZJ24F1214823 分析证书 Ab176084
ZJ24F1214822 分析证书 Ab176084
ZJ24F1214821 分析证书 Ab176084
ZJ24F0404250 分析证书 Ab176084
ZJ24F0404249 分析证书 Ab176084
ZJ24F0404248 分析证书 Ab176084

引用文献

1. Hahne M, Kataoka T, Schröter M, Hofmann K, Irmler M, Bodmer JL, Schneider P, Bornand T, Holler N, French LE et al..  (1998)  APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth..  J Exp Med,  188  (6): (1185-90).  [PMID:9743536]
2. López-Fraga M, Fernández R, Albar JP, Hahne M.  (2001)  Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase..  EMBO Rep,  (10): (945-51).  [PMID:11571266]
3. Shu, H B HB, Hu, W H WH and Johnson, H H..  (1999)  TALL-1 is a novel member of the TNF family that is down-regulated by mitogens..  Journal of leukocyte biology,  [PMID:10331498]
4. Kelly, K K, Manos, E E, Jensen, G G, Nadauld, L L and Jones, D A DA..  (2000)  APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death..  Cancer research,  (15): [PMID:10706119]
5. Yu, G G and 16 more authors..  (2000)  APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity..  Nature immunology,  [PMID:10973284]
6. Pradet-Balade, B B and 8 more authors..  (2002)  An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein..  The EMBO journal,  (1): [PMID:12411489]

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