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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab176084-100μg |
100μg |
现货 ![]() |
| |
| Ab176084-1mg |
1mg |
现货 ![]() |
| |
| Ab176084-5mg |
5mg |
现货 ![]() |
| |
| Ab176084-10mg |
10mg |
期货 ![]() |
|
| 产品名称 | Sibeprenlimab (anti-TNFSF13), 肿瘤坏死因子配体超家族成员 13 抑制剂 |
|---|---|
| 别名 | 西布瑞林单抗(抗肿瘤坏死因子FSF13) |
| 英文别名 | A proliferation-inducing ligand | APRIL | TALL-2 | TNF- and APOL-related leukocyte expressed ligand 2 | TNF-related death ligand 1 | TRDL-1 |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA |
| 宿主种属 | 人(Human) |
| 特异性 | TNFSF13 |
| 种属反应性 | 人(Human),小鼠(Mouse) |
| 偶联 | Unconjugated |
| 作用类型 | 抑制剂 |
| 作用机制 | 肿瘤坏死因子配体超家族成员 13 抑制剂 |
| 克隆类型 | 重组抗体 |
|---|---|
| Format | Whole IgG |
| 亚型 | Human IgG2SA |
| 轻链亚型 | kappa |
| SDS-PAGE | 27.4 kDa (Light Chain) & 51.7 kDa (Heavy Chain), under reducing conditions; 175.1 kDa, under non-reducing conditions. |
| 纯化方法 | Protein A purified |
| 纯度 | >95% |
| 物理外观 | Liquid |
| 储存缓冲液 | Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | 见COA |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。 |
| CAS编号和信息 | 2382896-07-1 |
| 分子类型 | 抗体 |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
Sibeprenlimab (anti-TNFSF13) (Ab176084) - Flow Cytometry
Flow Cytometry analysis of A549 cells labelling TNFSF13 (red) with Sibeprenlimab (anti-TNFSF13) (Ab176084). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Sibeprenlimab (anti-TNFSF13) (Ab176084) - SEC
The purity of Sibeprenlimab (anti-TNFSF13) (Ab176084) is more than 95% verified by HPLC.
通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | Ab176084 | |
| 分析证书 | Ab176084 | |
| 分析证书 | Ab176084 | |
| 分析证书 | Ab176084 | |
| 分析证书 | Ab176084 | |
| 分析证书 | Ab176084 |
| 1. Hahne M, Kataoka T, Schröter M, Hofmann K, Irmler M, Bodmer JL, Schneider P, Bornand T, Holler N, French LE et al.. (1998) APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth.. J Exp Med, 188 (6): (1185-90). [PMID:9743536] |
| 2. López-Fraga M, Fernández R, Albar JP, Hahne M. (2001) Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase.. EMBO Rep, 2 (10): (945-51). [PMID:11571266] |
| 3. Shu, H B HB, Hu, W H WH and Johnson, H H.. (1999) TALL-1 is a novel member of the TNF family that is down-regulated by mitogens.. Journal of leukocyte biology, [PMID:10331498] |
| 4. Kelly, K K, Manos, E E, Jensen, G G, Nadauld, L L and Jones, D A DA.. (2000) APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death.. Cancer research, (15): [PMID:10706119] |
| 5. Yu, G G and 16 more authors.. (2000) APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity.. Nature immunology, [PMID:10973284] |
| 6. Pradet-Balade, B B and 8 more authors.. (2002) An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein.. The EMBO journal, (1): [PMID:12411489] |