货号 (SKU)

包装规格

是否现货

价格

数量

Ab175886-100μg

100μg

现货

Ab175886-1mg

1mg

现货

Ab175886-5mg

5mg

现货

Ab175886-10mg

10mg

期货

基本信息

产品名称	Indusatumab (anti-GUCY2C)
别名	英度妥单抗
英文别名	GC-C antibody \| Guanylyl cyclase C antibody \| GUC2C antibody \| GUC2C_HUMAN antibody \| GUCY2C antibody \| Heat stable enterotoxin receptor antibody \| Heat-stable enterotoxin receptor antibody \| hSTAR antibody \| Intestinal guanylate cyclase antibody \| STA re
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	GUCY2C
种属反应性	人(Human),大鼠(Rat),猪(Pig),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	26.8 kDa (Light Chain) & 50.6 kDa (Heavy Chain), under reducing conditions; 179.3 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	1497400-26-6
分子类型	抗体

关联靶点（人）

GUCY2C Tclin 热稳定肠毒素受体(Heat-stable enterotoxin receptor) (0 活性数据)

点击查看靶蛋白信息： GUCY2C

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

SEC: Indusatumab (anti-GUCY2C) (Ab175886)

Indusatumab (anti-GUCY2C) (Ab175886) - SEC
The purity of Indusatumab (anti-GUCY2C) (Ab175886) is more than 95% verified by HPLC.

ELISA: Indusatumab (anti-GUCY2C) (Ab175886)

Indusatumab (anti-GUCY2C) (Ab175886) - ELISA
Immobilized Hu-GUCY2C-his at 2.0 μg/mL can bind Indusatumab (anti-GUCY2C) (Ab175886) with the EC₅₀ of 8.18 ng/mL.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到5个结果

批号(Lot Number)	证书类型	货号
ZJ23F1101791	分析证书	Ab175886
ZJ23F1101792	分析证书	Ab175886
ZJ24F0911522	分析证书	Ab175886
ZJ24F0911521	分析证书	Ab175886
ZJ24F0911520	分析证书	Ab175886

引用文献

1. Harris LA, Crowell MD. (2007) Linaclotide, a new direction in the treatment of irritable bowel syndrome and chronic constipation.. Curr Opin Mol Ther, 9 (4): (403-10). [PMID:17694454]
2. Busby RW, Bryant AP, Bartolini WP, Cordero EA, Hannig G, Kessler MM, Mahajan-Miklos S, Pierce CM, Solinga RM, Sun LJ et al.. (2010) Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit.. Eur J Pharmacol, 649 (1-3): (328-35). [PMID:20863829]
3. Shailubhai K, Palejwala V, Arjunan KP, Saykhedkar S, Nefsky B, Foss JA, Comiskey S, Jacob GS, Plevy SE. (2015) Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis.. World J Gastrointest Pharmacol Ther, 6 (4): (213-22). [PMID:26558155]
4. de Sauvage, F J FJ, Camerato, T R TR and Goeddel, D V DV.. (1991) Primary structure and functional expression of the human receptor for Escherichia coli heat-stable enterotoxin.. The Journal of biological chemistry, (25): [PMID:1680854]
5. Singh, S S, Singh, G G, Heim, J M JM and Gerzer, R R.. (1991) Isolation and expression of a guanylate cyclase-coupled heat stable enterotoxin receptor cDNA from a human colonic cell line.. Biochemical and biophysical research communications, (30): [PMID:1718270]
6. Mann, E A EA, Cohen, M B MB and Giannella, R A RA.. (1993) Comparison of receptors for Escherichia coli heat-stable enterotoxin: novel receptor present in IEC-6 cells.. The American journal of physiology, [PMID:8381596]
7. Mann, E A EA, Jump, M L ML and Glenella, R A RA.. (1996) Cell line-specific transcriptional activation of the promoter of the human guanylyl cyclase C/heat-stable enterotoxin/receptor gene.. Biochimica et biophysica acta, (7): [PMID:8605253]
8. Scott, Robert O RO, Thelin, William R WR and Milgram, Sharon L SL.. (2002) A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptor.. The Journal of biological chemistry, (21): [PMID:11950846]
9. Scherer, Steven E SE and 216 more authors.. (2006) The finished DNA sequence of human chromosome 12.. Nature, (16): [PMID:16541075]
10. Fiskerstrand, Torunn T and 15 more authors.. (2012) Familial diarrhea syndrome caused by an activating GUCY2C mutation.. The New England journal of medicine, (26): [PMID:22436048]
11. Romi, Hila H and 10 more authors.. (2012) Meconium ileus caused by mutations in GUCY2C, encoding the CFTR-activating guanylate cyclase 2C.. American journal of human genetics, (4): [PMID:22521417]
12. Busby, Robert W RW and 10 more authors.. (2013) Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation.. The Journal of pharmacology and experimental therapeutics, [PMID:23090647]
13. Arshad, Najla N, Ballal, Suhas S and Visweswariah, Sandhya S SS.. (2013) Site-specific N-linked glycosylation of receptor guanylyl cyclase C regulates ligand binding, ligand-mediated activation and interaction with vesicular integral membrane protein 36, VIP36.. The Journal of biological chemistry, (8): [PMID:23269669]
14. Mathur D, Root AR, Bugaj-Gaweda B, Bisulco S, Tan X, Fang W, Kearney JC, Lucas J, Guffroy M, Golas J et al.. (2020) A Novel GUCY2C-CD3 T-Cell Engaging Bispecific Construct (PF-07062119) for the Treatment of Gastrointestinal Cancers.. Clin Cancer Res, 26 (9): (2188-2202). [PMID:31996389]

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体积（添加到小瓶中）

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所需的复溶浓度

Indusatumab (anti-GUCY2C)

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器

Indusatumab (anti-GUCY2C)

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关产品

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器