Gevokizumab (anti-IL-1b), 白细胞介素-1β 负性异位调节剂

COA

级别和纯度:

≥95%(SDS-PAGE&SEC-HPLC)
见COA

应用:

Animal Model
ELISA
Flow Cytometry
Functional Assay

宿主种属: 人(Human)
种属反应性: 人(Human), 恒河猴(Rhesus monkey), 食蟹猴(Cynomolgus monkey)
亚型: Human IgG2
偶联: Unconjugated

有货

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货号 (SKU)	包装规格	是否现货
Ab175856-100μg	100μg	现货
Ab175856-1mg	1mg	现货
Ab175856-5mg	5mg	现货
Ab175856-10mg	10mg	期货

查看相关系列

点击查看靶蛋白信息: IL1B

Accession#:P01584 (8) Gene ID:3553 (10) IL1B (14)

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基本信息

产品名称	Gevokizumab (anti-IL-1b), 白细胞介素-1β 负性异位调节剂
别名	吉伏组单抗
英文别名	Catabolin antibody \| H1 antibody \| IFN beta inducing factor antibody \| IL 1 antibody \| IL 1 beta antibody \| IL-1 beta antibody \| IL1 antibody \| IL1 BETA antibody \| IL1B antibody \| IL1B_HUMAN antibody \| IL1F2 antibody \| Interleukin 1 beta antibody \| Interl
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	IL1B
种属反应性	人(Human),恒河猴(Rhesus monkey),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated
作用类型	负变构调节剂
作用机制	白细胞介素-1β 负性异位调节剂

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG2
轻链亚型	kappa
SDS-PAGE	26.8 kDa (Light Chain) & 51.4 kDa (Heavy Chain), under reducing conditions; 170.1 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	1129435-60-4
分子类型	抗体

关联靶点（人）

IL1B Tclin 白细胞介素-1β(Interleukin-1 beta) (0 活性数据)

点击查看靶蛋白信息： IL1B

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

ELISA: Gevokizumab (anti-IL-1b) (Ab175856)

Gevokizumab (anti-IL-1b) (Ab175856) - ELISA
Immobilized Recombinant Human IL-1 beta Protein (rp147346) at 1.0 μg/mL can bind Gevokizumab (anti-IL-1b) (Ab175856) with the EC₅₀ of 56.74 ng/mL.

SEC: Gevokizumab (anti-IL-1b) (Ab175856)

Gevokizumab (anti-IL-1b) (Ab175856) - SEC
The purity of Gevokizumab (anti-IL-1b) (Ab175856) is more than 95% verified by HPLC.

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C of A & Other Certificates(BSE/TSE, COO):

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通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到5个结果

批号(Lot Number)	证书类型	货号
ZJ23F1001515	分析证书	Ab175856
ZJ23F1001524	分析证书	Ab175856
ZJ24F0911317	分析证书	Ab175856
ZJ24F0911316	分析证书	Ab175856
ZJ24F0911315	分析证书	Ab175856

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引用文献

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4. Mizutani, H H, Schechter, N N, Lazarus, G G, Black, R A RA and Kupper, T S TS.. (1991) Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase.. The Journal of experimental medicine, (1): [PMID:1919436]
5. Clore, G M GM, Wingfield, P T PT and Gronenborn, A M AM.. (1991) High-resolution three-dimensional structure of interleukin 1 beta in solution by three- and four-dimensional nuclear magnetic resonance spectroscopy.. Biochemistry, (5): [PMID:2001363]
6. Finzel, B C BC and 5 more authors.. (1989) Crystal structure of recombinant human interleukin-1 beta at 2.0 A resolution.. Journal of molecular biology, (20): [PMID:2585509]
7. Bensi, G G and 5 more authors.. (1987) Human interleukin-1 beta gene.. Gene, [PMID:2954882]
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10. Zsebo, K M KM and 6 more authors.. (1988) Effects of hematopoietin-1 and interleukin 1 activities on early hematopoietic cells of the bone marrow.. Blood, [PMID:3281727]
11. Clark, B D BD, Collins, K L KL, Gandy, M S MS, Webb, A C AC and Auron, P E PE.. (1986) Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene.. Nucleic acids research, (24): [PMID:3490654]
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13. Auron, P E PE and 6 more authors.. (1984) Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:6083565]
14. Kapur, V V, Majesky, M W MW, Li, L L LL, Black, R A RA and Musser, J M JM.. (1993) Cleavage of interleukin 1 beta (IL-1 beta) precursor to produce active IL-1 beta by a conserved extracellular cysteine protease from Streptococcus pyogenes.. Proceedings of the National Academy of Sciences of the United States of America, (15): [PMID:7689226]
15. Amin, A R AR and 7 more authors.. (1996) A novel mechanism of action of tetracyclines: effects on nitric oxide synthases.. Proceedings of the National Academy of Sciences of the United States of America, (26): [PMID:8943052]
16. Vigers, G P GP, Anderson, L J LJ, Caffes, P P and Brandhuber, B J BJ.. (1997) Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta.. Nature, (13): [PMID:9062193]
17. Tominaga, K K and 7 more authors.. (2000) IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells.. International immunology, [PMID:10653850]
18. Nicklin, Martin J H MJ and 5 more authors.. (2002) A sequence-based map of the nine genes of the human interleukin-1 cluster.. Genomics, [PMID:11991722]
19. Oringer, R J RJ and 8 more authors.. (2002) Effect of locally delivered minocycline microspheres on markers of bone resorption.. Journal of periodontology, [PMID:12211491]
20. Nakahara, Hideko H and 6 more authors.. (2003) Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis.. Arthritis and rheumatism, [PMID:12794819]
21. Andrei, Cristina C and 5 more authors.. (2004) Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: Implications for inflammatory processes.. Proceedings of the National Academy of Sciences of the United States of America, (29): [PMID:15192144]
22. Reale, Marcella M and 5 more authors.. (2005) Acetylcholinesterase inhibitors effects on oncostatin-M, interleukin-1 beta and interleukin-6 release from lymphocytes of Alzheimer's disease patients.. Experimental gerontology, [PMID:15763393]
23. and Eby, George G.. (2005) Elimination of arthritis pain and inflammation for over 2 years with a single 90 min, topical 14% gallium nitrate treatment: case reports and review of actions of gallium III.. Medical hypotheses, [PMID:16122880]
24. Papin, S S and 8 more authors.. (2007) The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing.. Cell death and differentiation, [PMID:17431422]
25. Mishra, Bibhuti B BB and 6 more authors.. (2010) Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome.. Cellular microbiology, [PMID:20148899]
26. Hwang, Jaegyu J, Hwang, Heehong H, Lee, Ho-Won HW and Suk, Kyoungho K.. (2010) Microglia signaling as a target of donepezil.. Neuropharmacology, [PMID:20153342]
27. Wang, Dongli D and 5 more authors.. (2010) Structural insights into the assembly and activation of IL-1β with its receptors.. Nature immunology, [PMID:20802483]
28. Cronstein, Bruce N BN and Sunkureddi, Prashanth P.. (2013) Mechanistic aspects of inflammation and clinical management of inflammation in acute gouty arthritis.. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, [PMID:23319019]
29. Tran, Tran H TH, Pham, Jacqueline T JT, Shafeeq, Hira H, Manigault, Kendra R KR and Arya, Vibhuti V.. (2013) Role of interleukin-1 inhibitors in the management of gout.. Pharmacotherapy, [PMID:23553601]
30. Jourdan, Tony T and 13 more authors.. (2013) Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.. Nature medicine, [PMID:23955712]
31. Baroja-Mazo, Alberto A and 14 more authors.. (2014) The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response.. Nature immunology, [PMID:24952504]
32. Zhang, Tao T and 8 more authors.. (2015) Donepezil attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells through SIRT1 activation.. Cell stress & chaperones, [PMID:26194321]
33. LaRock, Christopher N CN and 8 more authors.. (2016) IL-1β is an innate immune sensor of microbial proteolysis.. Science immunology, [PMID:28331908]
34. Takada, Yoko K YK and 5 more authors.. (2017) Direct binding to integrins and loss of disulfide linkage in interleukin-1β (IL-1β) are involved in the agonistic action of IL-1β.. The Journal of biological chemistry, (8): [PMID:29030430]
35. LaRock, Doris L; Russell, Raedeen; Johnson, Anders F; Wilde, Shyra and LaRock, Christopher N.. (2020) Group A Streptococcus Infection of the Nasopharynx Requires Proinflammatory Signaling through the Interleukin-1 Receptor.. Infection and immunity, (18): [PMID:32719155]
36. Tian, X X and 6 more authors.. (2020) NLRP6-caspase 4 inflammasome activation in response to cariogenic bacterial lipoteichoic acid in human dental pulp inflammation.. International endodontic journal, (29): [PMID:33377178]
37. Driscoll, P C PC, Gronenborn, A M AM, Wingfield, P T PT and Clore, G M GM.. (1990) Determination of the secondary structure and molecular topology of interleukin-1 beta by use of two- and three-dimensional heteronuclear 15N-1H NMR spectroscopy.. Biochemistry, (15): [PMID:2372550]
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Gevokizumab (anti-IL-1b), 白细胞介素-1β 负性异位调节剂

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关产品

可替换产品

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器