货号 (SKU)

包装规格

是否现货

价格

数量

Ab175765-100μg

100μg

现货

Ab175765-1mg

1mg

现货

Ab175765-5mg

5mg

现货

Ab175765-10mg

10mg

期货

基本信息

产品名称	Fremanezumab (anti-CALCA), 降钙素基因相关肽拮抗剂的拮抗剂
别名	瑞玛奈珠单抗 \| Fremanezumab（抗 CALCA）
英文别名	Calcitonin/calcitonin related polypeptide alpha antibody \| Alpha type CGRP antibody \| Beta type CGRP antibody \| CALC1 antibody \| CALC2 antibody \| CALCA antibody \| CALCB antibody \| Calcitonin 1 antibody \| Calcitonin 2 antibody \| Calcitonin gene related pep
规格或纯度	无载体, 重组, ExactAb™, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	CALCA
种属反应性	人(Human)
偶联	Unconjugated
作用类型	拮抗剂
作用机制	降钙素基因相关肽拮抗剂的拮抗剂

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG2SA
轻链亚型	kappa
SDS-PAGE	27.2 kDa (Light Chain) & 49.8 kDa (Heavy Chain), under reducing conditions; 160.5 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95% (SDS-PAGE&SEC)
物理外观	Liquid
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	1655501-53-3
分子类型	抗体

关联靶点（人）

CALCA Tclin 降钙素基因相关肽1(Calcitonin gene-related peptide 1) (0 活性数据)

点击查看靶蛋白信息： CALCA

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

CALCA Tbio 降钙素(Calcitonin) (0 活性数据)

点击查看靶蛋白信息： CALCA

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

CALCA Tclin Calcitonin gene-related peptide 1 (214 活性数据)

点击查看靶蛋白信息： CALCA

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

ELISA: Fremanezumab (anti-CALCA) (Ab175765)

Fremanezumab (anti-CALCA) (Ab175765) - ELISA
Immobilized hu-CALCA-KLH at 2 μg/mL can bind Fremanezumab (anti-CALCA) (Ab175765) with the EC₅₀ of 6.76 ng/mL.

SEC: Fremanezumab (anti-CALCA) (Ab175765)

Fremanezumab (anti-CALCA) (Ab175765) - SEC
The purity of Fremanezumab (anti-CALCA) (Ab175765) is more than 95% verified by HPLC.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到6个结果

批号(Lot Number)	证书类型	货号
ZJ25F0724328	分析证书	Ab175765
ZJ25F0724327	分析证书	Ab175765
ZJ25F0724326	分析证书	Ab175765
ZJ24F0404235	分析证书	Ab175765
ZJ24F0404234	分析证书	Ab175765
ZJ24F0404233	分析证书	Ab175765

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引用文献

1. Recober A, Russo AF. (2007) Olcegepant, a non-peptide CGRP1 antagonist for migraine treatment.. IDrugs, 10 (8): (566-74). [PMID:17665333]
2. Migliore M, Habrant D, Sasso O, Albani C, Bertozzi SM, Armirotti A, Piomelli D, Scarpelli R. (2016) Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies.. Eur J Med Chem, 109 (216-37). [PMID:26774927]
3. Xu R, Wang K, Rizzi JP, Huang H, Grina JA, Schlachter ST, Wang B, Wehn PM, Yang H, Dixon DD et al.. (2019) 3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma.. J Med Chem, 62 (15): (6876-6893). [PMID:31282155]
4. Miranda LP, Holder JR, Shi L, Bennett B, Aral J, Gegg CV, Wright M, Walker K, Doellgast G, Rogers R, Li H, Valladares V, Salyers K, Johnson E, Wild K.. (2008) Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor.. J Med Chem, 51 (24): (7889-7897). [PMID:19053766] [10.1021/jm8009298]
5. Civiello RL, Han X, Beno BR, Chaturvedula PV, Herbst JJ, Xu C, Conway CM, Macor JE, Dubowchik GM.. (2016) Synthesis and SAR of calcitonin gene-related peptide (CGRP) antagonists containing substituted aryl-piperazines and piperidines.. Bioorg Med Chem Lett, 26 (4): (1229-1232). [PMID:26832218] [10.1016/j.bmcl.2016.01.026]
6. Waszkielewicz AM, Gunia-Krzyżak A, Powroźnik B, Słoczyńska K, Pękala E, Walczak M, Bednarski M, Żesławska E, Nitek W, Marona H.. (2016) Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.. Bioorg Med Chem, 24 (8): (1793-1810). [PMID:26988801] [10.1016/j.bmc.2016.03.006]
7. Kitamura, K K and 5 more authors.. (1992) Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma.. Biochemical and biophysical research communications, (29): [PMID:1318039]
8. Breeze, A L AL, Harvey, T S TS, Bazzo, R R and Campbell, I D ID.. (1991) Solution structure of human calcitonin gene-related peptide by 1H NMR and distance geometry with restrained molecular dynamics.. Biochemistry, (15): [PMID:1988044]
9. Hubbard, J A JA and 5 more authors.. (1991) Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin.. The Biochemical journal, (1): [PMID:2039456]
10. Edbrooke, M R MR and 6 more authors.. (1985) Expression of the human calcitonin/CGRP gene in lung and thyroid carcinoma.. The EMBO journal, [PMID:2408883]
11. Broad, P M PM, Symes, A J AJ, Thakker, R V RV and Craig, R K RK.. (1989) Structure and methylation of the human calcitonin/alpha-CGRP gene.. Nucleic acids research, (12): [PMID:2571128]
12. Craig, R K RK and 7 more authors.. (1986) Expression and function of the human calcitonin/alpha-CGRP gene in health and disease.. Biochemical Society symposium, [PMID:3034287]
13. Petermann, J B JB, Born, W W, Chang, J Y JY and Fischer, J A JA.. (1987) Identification in the human central nervous system, pituitary, and thyroid of a novel calcitonin gene-related peptide, and partial amino acid sequence in the spinal cord.. The Journal of biological chemistry, (15): [PMID:3492492]
14. Jonas, V V and 7 more authors.. (1985) Alternative RNA processing events in human calcitonin/calcitonin gene-related peptide gene expression.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:3872459]
15. Nelkin, B D BD and 5 more authors.. (1984) Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide.. Biochemical and biophysical research communications, (17): [PMID:6148938]
16. Morris, H R HR and 5 more authors.. (1984) Isolation and characterization of human calcitonin gene-related peptide.. Nature, [PMID:6609312]
17. Steenbergh, P H PH and 5 more authors.. (1984) Calcitonin gene related peptide coding sequence is conserved in the human genome and is expressed in medullary thyroid carcinoma.. The Journal of clinical endocrinology and metabolism, [PMID:6610687]
18. Dodick, David W DW and 13 more authors.. (2014) Safety and efficacy of ALD403, an antibody to calcitonin gene-related peptide, for the prevention of frequent episodic migraine: a randomised, double-blind, placebo-controlled, exploratory phase 2 trial.. The Lancet. Neurology, [PMID:25297013]
19. Monteith, David D and 8 more authors.. (2017) Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the CGRP Binding Monoclonal Antibody LY2951742 (Galcanezumab) in Healthy Volunteers.. Frontiers in pharmacology, [PMID:29089894]

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Fremanezumab (anti-CALCA), 降钙素基因相关肽拮抗剂的拮抗剂

库存信息

库存信息

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库存信息

基本信息

产品属性

关联靶点（人）

作用机制

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质检证书（CoA,COO,BSE/TSE 和分析图谱)

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引用文献

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摩尔浓度计算器

稀释计算器

复溶计算器

Fremanezumab (anti-CALCA), 降钙素基因相关肽拮抗剂的拮抗剂

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关产品

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引用文献

溶液计算器

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