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Vunakizumab (anti-IL-17a), 白细胞介素 17A 抑制剂

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human), 大鼠(Rat), 小鼠(Mouse), 食蟹猴(Cynomolgus monkey)
  • 亚型: Human IgG1
  • 偶联: Unconjugated
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货号 (SKU) 包装规格 是否现货 价格 数量
Ab175703-100μg
100μg 现货 Stock Image
Ab175703-1mg
1mg 现货 Stock Image
Ab175703-5mg
5mg 现货 Stock Image
Ab175703-10mg
10mg 期货 Stock Image

基本信息

产品名称 Vunakizumab (anti-IL-17a), 白细胞介素 17A 抑制剂
别名 伏那吉珠单抗 | 武那单抗(抗 IL-17a)
英文别名 CTLA 8 antibody | CTLA-8 antibody | CTLA8 antibody | cytotoxic T lymphocyte associated antigen 8 antibody | Cytotoxic T lymphocyte associated protein 8 antibody | Cytotoxic T lymphocyte associated serine esterase 8 antibody | Cytotoxic T-lymphocyte-associ
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 IL17A
种属反应性 人(Human),大鼠(Rat),小鼠(Mouse),食蟹猴(Cynomolgus monkey)
偶联 Unconjugated
作用类型 抑制剂
作用机制 白细胞介素 17A 抑制剂

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG1
轻链亚型 kappa
SDS-PAGE 146.38 kDa
纯化方法 Protein A purified
纯度 >95%
物理外观 Liquid
储存缓冲液 Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0.
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 1792181-33-9
分子类型 抗体

关联靶点(人)

IL17A Tclin 白细胞介素-17A(Interleukin-17A) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

Vunakizumab (anti-IL-17a) (Ab175703) - ELISA
Immobilized hu-IL-17A at 1.0 μg/mL can bind Vunakizumab (anti-IL-17a) (Ab175703) with the EC₅₀ of 48.60 ng/mL.

Vunakizumab (anti-IL-17a) (Ab175703) - SEC
The purity of Vunakizumab (anti-IL-17a) (Ab175703) is more than 95% verified by HPLC.

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!

找到5个结果

批号(Lot Number) 证书类型 货号
ZJ23F1201946 分析证书 Ab175703
ZJ23F1201947 分析证书 Ab175703
ZJ24F1214874 分析证书 Ab175703
ZJ24F1214873 分析证书 Ab175703
ZJ24F1214872 分析证书 Ab175703

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引用文献

1. Ohtsuki M, Morita A, Abe M, Takahashi H, Seko N, Karpov A, Shima T, Papavassilis C, Nakagawa H, ERASURE Study Japanese subgroup.  (2014)  Secukinumab efficacy and safety in Japanese patients with moderate-to-severe plaque psoriasis: subanalysis from ERASURE, a randomized, placebo-controlled, phase 3 study..  J Dermatol,  41  (12): (1039-46).  [PMID:25354738]
2. Wright JF, Bennett F, Li B, Brooks J, Luxenberg DP, Whitters MJ, Tomkinson KN, Fitz LJ, Wolfman NM, Collins M et al..  (2008)  The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex..  J Immunol,  181  (4): (2799-805).  [PMID:18684971]
3. Yao, Z Z and 6 more authors..  (1995)  Human IL-17: a novel cytokine derived from T cells..  Journal of immunology (Baltimore, Md. : 1950),  (15): [PMID:7499828]
4. Fossiez, F F and 16 more authors..  (1996)  T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines..  The Journal of experimental medicine,  (1): [PMID:8676080]
5. Wright, Jill F JF and 12 more authors..  (2007)  Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells..  The Journal of biological chemistry,  (4): [PMID:17355969]
6. Kuestner, Rolf E RE and 27 more authors..  (2007)  Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F..  Journal of immunology (Baltimore, Md. : 1950),  (15): [PMID:17911633]
7. Liu, Caini C and 9 more authors..  (2009)  Act1, a U-box E3 ubiquitin ligase for IL-17 signaling..  Science signaling,  (13): [PMID:19825828]
8. Gerhardt, Stefan S and 22 more authors..  (2009)  Structure of IL-17A in complex with a potent, fully human neutralizing antibody..  Journal of molecular biology,  (18): [PMID:19835883]
9. Puel, Anne A and 23 more authors..  (2011)  Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity..  Science (New York, N.Y.),  (1): [PMID:21350122]
10. Boisson, Bertrand B and 12 more authors..  (2013)  An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis..  Immunity,  (17): [PMID:24120361]
11. Acharya, Dhiraj D and 11 more authors..  (2017)  Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus Clearance..  Journal of virology,  (1): [PMID:27795421]
12. Goepfert, Arnaud A, Lehmann, Sylvie S, Wirth, Emmanuelle E and Rondeau, Jean-Michel JM..  (2017)  The human IL-17A/F heterodimer: a two-faced cytokine with unique receptor recognition properties..  Scientific reports,  (21): [PMID:28827714]
13. Goepfert, Arnaud; Lehmann, Sylvie; Blank, Jutta; Kolbinger, Frank and Rondeau, Jean-Michel..  (2020)  Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling..  Immunity,  (17): [PMID:32187518]

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