货号 (SKU)

包装规格

是否现货

价格

数量

Ab175625-100μg

100μg

现货

Ab175625-1mg

1mg

现货

Ab175625-5mg

5mg

现货

Ab175625-10mg

10mg

期货

基本信息

产品名称	Pascolizumab (anti-IL-4), 白细胞介素-4 抑制剂
别名	帕考珠单抗 \| 帕考珠单抗(抗 IL-4)
英文别名	B cell growth factor 1 antibody \| B cell IgG differentiation factor antibody \| B Cell Stimulatory Factor 1 antibody \| B-cell stimulatory factor 1 antibody \| BCGF 1 antibody \| BCGF1 antibody \| Binetrakin antibody \| BSF-1 antibody \| BSF1 antibody \| IGG1 ind
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	IL4
种属反应性	人(Human),小鼠(Mouse)
偶联	Unconjugated
作用类型	抑制剂
作用机制	白细胞介素-4 抑制剂

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	26.6 kDa (Light Chain) & 51.1 kDa (Heavy Chain), under reducing conditions; 176.4 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	331243-22-2
分子类型	抗体

关联靶点（人）

IL4 Tbio 白细胞介素-4(Interleukin-4) (0 活性数据)

点击查看靶蛋白信息： IL4

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

ELISA: Pascolizumab (anti-IL-4) (Ab175625)

Pascolizumab (anti-IL-4) (Ab175625) - ELISA
Immobilized hu-IL-4-his at 2.0 μg/mL can bind Pascolizumab (anti-IL-4) (Ab175625) with the EC₅₀ of 88.83 ng/mL.

SEC: Pascolizumab (anti-IL-4) (Ab175625)

Pascolizumab (anti-IL-4) (Ab175625) - SEC
The purity of Pascolizumab (anti-IL-4) (Ab175625) is more than 95% verified by HPLC.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到6个结果

批号(Lot Number)	证书类型	货号
ZJ24F1114126	分析证书	Ab175625
ZJ24F1114125	分析证书	Ab175625
ZJ24F1114124	分析证书	Ab175625
ZJ24F0202892	分析证书	Ab175625
ZJ24F0202891	分析证书	Ab175625
ZJ24F0202890	分析证书	Ab175625

可替换产品

引用文献

1. Hart TK, Blackburn MN, Brigham-Burke M, Dede K, Al-Mahdi N, Zia-Amirhosseini P, Cook RM. (2002) Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthma.. Clin Exp Immunol, 130 (1): (93-100). [PMID:12296858]
2. Walter, M R MR and 9 more authors.. (1992) Crystal structure of recombinant human interleukin-4.. The Journal of biological chemistry, (5): [PMID:1400355]
3. Wlodawer, A A, Wlodaver, A A, Pavlovsky, A A and Gustchina, A A.. (1992) Crystal structure of human recombinant interleukin-4 at 2.25 A resolution.. FEBS letters, (31): [PMID:1511746]
4. Powers, R R and 5 more authors.. (1992) 1H, 15N, 13C, and 13CO assignments of human interleukin-4 using three-dimensional double- and triple-resonance heteronuclear magnetic resonance spectroscopy.. Biochemistry, (5): [PMID:1567880]
5. Garrett, D S DS and 5 more authors.. (1992) Determination of the secondary structure and folding topology of human interleukin-4 using three-dimensional heteronuclear magnetic resonance spectroscopy.. Biochemistry, (5): [PMID:1567881]
6. Smith, L J LJ and 6 more authors.. (1992) Human interleukin 4. The solution structure of a four-helix bundle protein.. Journal of molecular biology, (20): [PMID:1569578]
7. Redfield, C C and 6 more authors.. (1991) Secondary structure and topology of human interleukin 4 in solution.. Biochemistry, (19): [PMID:1932028]
8. Curtis, B M BM and 8 more authors.. (1991) Experimental and theoretical studies of the three-dimensional structure of human interleukin-4.. Proteins, [PMID:1946344]
9. Carr, C C, Aykent, S S, Kimack, N M NM and Levine, A D AD.. (1991) Disulfide assignments in recombinant mouse and human interleukin 4.. Biochemistry, (12): [PMID:1993171]
10. Arai, N N and 9 more authors.. (1989) Complete nucleotide sequence of the chromosomal gene for human IL-4 and its expression.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:2535858]
11. Yokota, T T and 8 more authors.. (1986) Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:3016727]
12. Eder, A A, Krafft-Czepa, H H and Krammer, P H PH.. (1988) The 5' region of the human interleukin 4 gene: structure and potential regulatory elements.. Nucleic acids research, (25): [PMID:3257560]
13. Smith, L J LJ and 8 more authors.. (1994) Comparison of four independently determined structures of human recombinant interleukin-4.. Nature structural biology, [PMID:7664036]
14. Klein, S C SC, Golverdingen, J G JG, Bouwens, A G AG, Tilanus, M G MG and de Weger, R A RA.. (1995) An alternatively spliced interleukin 4 form in lymphoid cells.. Immunogenetics, [PMID:7806280]
15. Müller, T T, Dieckmann, T T, Sebald, W W and Oschkinat, H H.. (1994) Aspects of receptor binding and signalling of interleukin-4 investigated by site-directed mutagenesis and NMR spectroscopy.. Journal of molecular biology, (8): [PMID:8151703]
16. Hage, T T, Sebald, W W and Reinemer, P P.. (1999) Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface.. Cell, (16): [PMID:10219247]
17. Hülsmeyer, M M, Scheufler, C C and Dreyer, M K MK.. (2001) Structure of interleukin 4 mutant E9A suggests polar steering in receptor-complex formation.. Acta crystallographica. Section D, Biological crystallography, [PMID:11526337]
18. Zee, Robert Y L RY and 6 more authors.. (2004) Polymorphism in the P-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis.. Human molecular genetics, (15): [PMID:14681304]
19. LaPorte, Sherry L SL and 7 more authors.. (2008) Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system.. Cell, (25): [PMID:18243101]
20. Powers, R R and 5 more authors.. (1992) Three-dimensional solution structure of human interleukin-4 by multidimensional heteronuclear magnetic resonance spectroscopy.. Science (New York, N.Y.), (19): [PMID:1609277]
21. Malabarba, M G MG and 7 more authors.. (1995) Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor alpha.. The Journal of biological chemistry, (21): [PMID:7721895]

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所需的复溶浓度

Pascolizumab (anti-IL-4), 白细胞介素-4 抑制剂

库存信息

库存信息

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基本信息

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关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器

Pascolizumab (anti-IL-4), 白细胞介素-4 抑制剂

库存信息

库存信息

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库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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引用文献

溶液计算器

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