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Lintuzumab (anti-CD33), CD33 抗体

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human)
  • 亚型: Human IgG1
  • 偶联: Unconjugated
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货号 (SKU) 包装规格 是否现货 价格 数量
Ab175581-100μg
100μg 现货 Stock Image
Ab175581-1mg
1mg 现货 Stock Image
Ab175581-5mg
5mg 现货 Stock Image
Ab175581-10mg
10mg 期货 Stock Image

基本信息

产品名称 Lintuzumab (anti-CD33), CD33 抗体
别名 林妥珠单抗 | 林妥珠单抗(抗 CD33)
英文别名 CD 33 antibody | CD33 antibody | CD33 antigen (gp67) antibody | CD33 antigen antibody | CD33 molecule antibody | CD33_HUMAN antibody | FLJ00391 antibody | gp67 antibody | My9 antibody | Myeloid cell surface antigen CD33 antibody | Myeloid differentiation
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 CD33
种属反应性 人(Human)
偶联 Unconjugated
作用类型 其它
作用机制 CD33 抗体

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG1
轻链亚型 kappa
SDS-PAGE 145.24 kDa
纯化方法 Protein A purified
物理外观 Liquid
储存缓冲液 Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH5.0.
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS编号和信息 166089-32-3
分子类型 抗体

关联靶点(人)

CD33 Tclin 髓系细胞表面抗原 CD33(Myeloid cell surface antigen CD33) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

Lintuzumab (anti-CD33) (Ab175581) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood monocytes labelling CD33 with Lintuzumab (anti-CD33) (Ab175581) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).

Lintuzumab (anti-CD33) (Ab175581) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood monocytes labelling CD33 (red) with Lintuzumab (anti-CD33) (Ab175581) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.

Lintuzumab (anti-CD33) (Ab175581) - SEC
The purity of Lintuzumab (anti-CD33) (Ab175581) is more than 95% verified by HPLC.

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批号(Lot Number) 证书类型 货号
ZJ24F0708647 分析证书 Ab175581
ZJ24F0708646 分析证书 Ab175581
ZJ24F0708645 分析证书 Ab175581

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引用文献

1. Taylor VC, Buckley CD, Douglas M, Cody AJ, Simmons DL, Freeman SD.  (1999)  The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2..  J Biol Chem,  274  (17): (11505-12).  [PMID:10206955]
2. Ulyanova T, Blasioli J, Woodford-Thomas TA, Thomas ML.  (1999)  The sialoadhesin CD33 is a myeloid-specific inhibitory receptor..  Eur J Immunol,  29  (11): (3440-9).  [PMID:10556798]
3. Ferlazzo G, Spaggiari GM, Semino C, Melioli G, Moretta L.  (2000)  Engagement of CD33 surface molecules prevents the generation of dendritic cells from both monocytes and CD34+ myeloid precursors..  Eur J Immunol,  30  (3): (827-33).  [PMID:10741398]
4. Paul SP, Taylor LS, Stansbury EK, McVicar DW.  (2000)  Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2..  Blood,  96  (2): (483-90).  [PMID:10887109]
5. Caron PC, Co MS, Bull MK, Avdalovic NM, Queen C, Scheinberg DA.  (1992)  Biological and immunological features of humanized M195 (anti-CD33) monoclonal antibodies..  Cancer Res,  52  (24): (6761-7).  [PMID:1458463]
6. Garnache-Ottou F, Chaperot L, Biichle S, Ferrand C, Remy-Martin JP, Deconinck E, de Tailly PD, Bulabois B, Poulet J, Kuhlein E et al..  (2005)  Expression of the myeloid-associated marker CD33 is not an exclusive factor for leukemic plasmacytoid dendritic cells..  Blood,  105  (3): (1256-64).  [PMID:15388576]

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