货号 (SKU)

包装规格

是否现货

价格

数量

Ab175562-100μg

100μg

现货

Ab175562-1mg

1mg

现货

Ab175562-5mg

5mg

现货

Ab175562-10mg

10mg

期货

基本信息

产品名称	Inclacumab (anti-CD62p), 选择素 P（CD62）抗体
别名	因克拉库单抗(抗 CD62p)
英文别名	CD62 antigen-like family member P \| GMP-140 \| Granule membrane protein 140 \| LECAM3 \| Leukocyte-endothelial cell adhesion molecule 3 \| PADGEM \| Platelet activation dependent granule-external membrane protein
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	SELP
种属反应性	人(Human),大鼠(Rat),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated
作用类型	拮抗剂
作用机制	选择素 P（CD62）抗体

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG4SP
轻链亚型	kappa
SDS-PAGE	26.8 kDa (Light Chain) & 52.0 kDa (Heavy Chain), under reducing conditions; 178.3 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	1256258-86-2
分子类型	抗体

关联靶点（人）

SELP Tclin P选择素(P-selectin) (0 活性数据)

点击查看靶蛋白信息： SELP

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

ELISA: Inclacumab (anti-CD62p) (Ab175562)

Inclacumab (anti-CD62p) (Ab175562) - ELISA
Immobilized Human P-Selectin/CD62p-Fc Tag at 2.0 μg/mL can bind Inclacumab (anti-CD62p) (Ab175562) with the EC₅₀ of 8.58 ng/mL.

SEC: Inclacumab (anti-CD62p) (Ab175562)

Inclacumab (anti-CD62p) (Ab175562) - SEC
The purity of Inclacumab (anti-CD62p) (Ab175562) is more than 95% verified by HPLC.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到3个结果

批号(Lot Number)	证书类型	货号
ZJ24F0303921	分析证书	Ab175562
ZJ24F0303920	分析证书	Ab175562
ZJ24F0303919	分析证书	Ab175562

可替换产品

引用文献

1. Golik J, Dickey JK, Todderud G, Lee D, Alford J, Huang S, Klohr S, Eustice D, Aruffo A, Agler ML.. (1997) Isolation and structure determination of sulfonoquinovosyl dipalmitoyl glyceride, a P-selectin receptor inhibitor from the alga Dictyochloris fragrans.. J Nat Prod, 60 (4): (387-389). [PMID:9134746] [10.1021/np9606761]
2. Chang J, Patton JT, Sarkar A, Ernst B, Magnani JL, Frenette PS. (2010) GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice.. Blood, 116 (10): (1779-86). [PMID:20508165]
3. Ulbrich HK, Luxenburger A, Prech P, Eriksson EE, Soehnlein O, Rotzius P, Lindbom L, Dannhardt G.. (2006) A novel class of potent nonglycosidic and nonpeptidic pan-selectin inhibitors.. J Med Chem, 49 (20): (5988-5999). [PMID:17004713] [10.1021/jm060468y]
4. Kaila N, Janz K, Huang A, Moretto A, DeBernardo S, Bedard PW, Tam S, Clerin V, Keith JC, Tsao DH, Sushkova N, Shaw GD, Camphausen RT, Schaub RG, Wang Q.. (2007) 2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[H]quinoline-4-carboxylic acid (PSI-697): identification of a clinical candidate from the quinoline salicylic acid series of P-selectin antagonists.. J Med Chem, 50 (1): (40-64). [PMID:17201409] [10.1021/jm060631p]
5. Dafik L, d'Alarcao M, Kumar K.. (2010) Modulation of cellular adhesion by glycoengineering.. J Med Chem, 53 (10): (4277-4284). [PMID:20438083] [10.1021/jm100374g]
6. Huang A, Moretto A, Janz K, Lowe M, Bedard PW, Tam S, Di L, Clerin V, Sushkova N, Tchernychev B, Tsao DH, Keith JC, Shaw GD, Schaub RG, Wang Q, Kaila N.. (2010) Discovery of 2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid (PSI-421), a P-selectin inhibitor with improved pharmacokinetic properties and oral efficacy in models of vascular injury.. J Med Chem, 53 (16): (6003-6017). [PMID:20718494] [10.1021/jm9013696]
7. Wu J, Zhao M, Wang Y, Wang Y, Zhu H, Zhao S, Peng S.. (2016) A novel lead of P-selectin inhibitor: Discovery, synthesis, bioassays and action mechanism.. Bioorg Med Chem Lett, 26 (19): (4631-4636). [PMID:27575475] [10.1016/j.bmcl.2016.08.061]
8. Johnston, G I GI, Cook, R G RG and McEver, R P RP.. (1989) Cloning of GMP-140, a granule membrane protein of platelets and endothelium: sequence similarity to proteins involved in cell adhesion and inflammation.. Cell, (24): [PMID:2466574]
9. Bajorath, J J, Stenkamp, R R and Aruffo, A A.. (1993) Knowledge-based model building of proteins: concepts and examples.. Protein science : a publication of the Protein Society, [PMID:7505680]
10. Wilkins, P P PP, Moore, K L KL, McEver, R P RP and Cummings, R D RD.. (1995) Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin.. The Journal of biological chemistry, (29): [PMID:7559387]
11. Sako, D D and 5 more authors.. (1995) A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding.. Cell, (20): [PMID:7585949]
12. Pouyani, T T and Seed, B B.. (1995) PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus.. Cell, (20): [PMID:7585950]
13. Fujimoto, T T and 6 more authors.. (1993) P-selectin is acylated with palmitic acid and stearic acid at cysteine 766 through a thioester linkage.. The Journal of biological chemistry, (25): [PMID:7684381]
14. Freedman, S J SJ and 5 more authors.. (1996) Structure and function of the epidermal growth factor domain of P-selectin.. Biochemistry, (29): [PMID:8901515]
15. Herrmann, S M SM and 8 more authors.. (1998) The P-selectin gene is highly polymorphic: reduced frequency of the Pro715 allele carriers in patients with myocardial infarction.. Human molecular genetics, [PMID:9668170]
16. Somers, W S WS, Tang, J J, Shaw, G D GD and Camphausen, R T RT.. (2000) Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1.. Cell, (27): [PMID:11081633]
17. Florian, V V, Schlüter, T T and Bohnensack, R R.. (2001) A new member of the sorting nexin family interacts with the C-terminus of P-selectin.. Biochemical and biophysical research communications, (9): [PMID:11237770]
18. Zee, Robert Y L RY and 6 more authors.. (2004) Polymorphism in the P-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis.. Human molecular genetics, (15): [PMID:14681304]
19. Knauth, Peter P and 7 more authors.. (2005) Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking.. Journal of molecular biology, (8): [PMID:15769472]
20. Lewandrowski, Urs U, Moebius, Jan J, Walter, Ulrich U and Sickmann, Albert A.. (2006) Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.. Molecular & cellular proteomics : MCP, [PMID:16263699]
21. Kerr, Sheena C SC, Fieger, Claudia B CB, Snapp, Karen R KR and Rosen, Steven D SD.. (2008) Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:18606703]
22. Mehta-D'souza, Padmaja P and 8 more authors.. (2017) Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force.. The Journal of biological chemistry, (10): [PMID:28011641]
23. Cargill, M M and 17 more authors.. (1999) Characterization of single-nucleotide polymorphisms in coding regions of human genes.. Nature genetics, [PMID:10391209]

溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

浓度

体积

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

体积 1 (V1)

浓度 2 (C2)

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

Inclacumab (anti-CD62p), 选择素 P（CD62）抗体

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

可替换产品

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器

Inclacumab (anti-CD62p), 选择素 P（CD62）抗体

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关产品

可替换产品

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器