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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab175531-100μg |
100μg |
现货 ![]() |
| |
| Ab175531-1mg |
1mg |
现货 ![]() |
| |
| Ab175531-5mg |
5mg |
现货 ![]() |
| |
| Ab175531-10mg |
10mg |
期货 ![]() |
|
| 产品名称 | Epcoritamab (anti-CD3&CD20), CD20(跨膜 4-结构域;A 亚家族;成员 1)抗体;CD3e 抗体 |
|---|---|
| 别名 | 艾可瑞妥单抗 | CD3抗体 | CD3药靶抗体 | CD20抗体 | CD20药靶抗体 | CD3E抗体 | CD3E药靶抗体 | MS4A1抗体 | MS4A1药靶抗体 |
| 英文别名 | CD3 epsilon antibody | CD3e antibody | CD3e antigen antibody | CD3e antigen epsilon polypeptide (TiT3 complex) antibody | CD3E antigen epsilon polypeptide antibody | CD3E antigen, epsilon subunit antibody | CD3e molecule epsilon antibody | CD3e molecule, |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥90%(SDS-PAGE&SEC-HPLC), 见COA |
| 生化机理 | CD3: The CD3 complex mediates signal transduction. CD20: This protein may be involved in the regulation of B-cell activation and proliferation. |
| 宿主种属 | 人(Human) |
| 特异性 | CD3E & MS4A1 |
| 种属反应性 | 人(Human),食蟹猴(Cynomolgus monkey) |
| 偶联 | Unconjugated |
| 作用类型 | 结合剂 |
| 作用机制 | CD20(跨膜 4-结构域;A 亚家族;成员 1)抗体;CD3e 抗体 |
| 克隆类型 | 重组抗体 |
|---|---|
| Format | Whole IgG |
| 亚型 | Human IgG1 |
| 轻链亚型 | kappa - lambda |
| SDS-PAGE | 146.28 kDa |
| 纯化方法 | Protein A purified |
| 储存缓冲液 | Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | 见COA |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS编号和信息 | 2134641-34-0 |
| 分子类型 | 抗体 |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
Epcoritamab (anti-CD3&CD20) (Ab175531) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD3&CD20 (red) with Epcoritamab (anti-CD3&CD20) (Ab175531) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Epcoritamab (anti-CD3&CD20) (Ab175531) - ELISA
Immobilized Recombinant Human CD3 epsilon protein (rp175910) at 1.0 μg/mL can bind Epcoritamab (anti-CD3&CD20) (Ab175531) with the EC₅₀ of 39.7 ng/mL.
Epcoritamab (anti-CD3&CD20) (Ab175531) - SEC
The purity of Epcoritamab (anti-CD3&CD20) (Ab175531) is more than 95% verified by HPLC.
通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | Ab175531 | |
| 分析证书 | Ab175531 | |
| 分析证书 | Ab175531 |
| 1. van der Horst HJ, de Jonge AV, Hiemstra IH, Gelderloos AT, Berry DRAI, Hijmering NJ, van Essen HF, de Jong D, Chamuleau MED, Zweegman S et al.. (2021) Epcoritamab induces potent anti-tumor activity against malignant B-cells from patients with DLBCL, FL and MCL, irrespective of prior CD20 monoclonal antibody treatment.. Blood Cancer J, 11 (2): (38). [PMID:33602901] |
| 2. Engelberts PJ, Hiemstra IH, de Jong B, Schuurhuis DH, Meesters J, Beltran Hernandez I, Oostindie SC, Neijssen J, van den Brink EN, Horbach GJ et al.. (2020) DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing.. EBioMedicine, 52 (102625). [PMID:31981978] |