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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab175460-100μg |
100μg |
现货 ![]() |
| |
| Ab175460-1mg |
1mg |
现货 ![]() |
| |
| Ab175460-5mg |
5mg |
现货 ![]() |
| |
| Ab175460-10mg |
10mg |
期货 ![]() |
|
| 产品名称 | Avizakimab (anti-IL-21) |
|---|---|
| 别名 | 艾维奇单抗 | 阿维扎单抗(抗 IL-21) |
| 英文别名 | CVID11 antibody | IL 21 antibody | IL-21 antibody | Il21 antibody | IL21_HUMAN antibody | Interleukin 21 antibody | Interleukin-21 antibody | interleukin-21 isoform antibody | Interleukin21 antibody | OTTHUMP00000164088 antibody | Za11 antibody | CVID11 | |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA |
| 宿主种属 | 人(Human) |
| 特异性 | IL21 |
| 种属反应性 | 人(Human) |
| 偶联 | Unconjugated |
| 作用类型 | 抑制剂 |
| 克隆类型 | 重组抗体 |
|---|---|
| Format | Whole IgG |
| 亚型 | Human IgG1 |
| 轻链亚型 | kappa |
| SDS-PAGE | 27.2 kDa (Light Chain) & 51.9 kDa (Heavy Chain), under reducing conditions; 187.5 kDa, under non-reducing conditions. |
| 纯化方法 | Protein A purified |
| 纯度 | >95% |
| 物理外观 | Liquid |
| 储存缓冲液 | Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH5.0. |
| 防腐剂 | No |
| 浓度 | 见COA |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。 |
| CAS编号和信息 | 2229685-51-0 |
| 分子类型 | 抗体 |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
Avizakimab (anti-IL-21) (Ab175460) - ELISA
Immobilized Human IL-21-Fc Tag at 2.0 μg/mL can bind Avizakimab (anti-IL-21) (Ab175460) with the EC₅₀ of 549.90 ng/mL.
Avizakimab (anti-IL-21) (Ab175460) - SEC
The purity of Avizakimab (anti-IL-21) (Ab175460) is more than 95% verified by HPLC.
通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | Ab175460 | |
| 分析证书 | Ab175460 | |
| 分析证书 | Ab175460 |
| 1. Wang S, Wang J, Kumar V, Karnell JL, Naiman B, Gross PS, Rahman S, Zerrouki K, Hanna R, Morehouse C et al.. (2018) IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE.. Nat Commun, 9 (1): (1758). [PMID:29717110] |
| 2. Satterthwaite AB. (2021) TLR7 Signaling in Lupus B Cells: New Insights into Synergizing Factors and Downstream Signals.. Curr Rheumatol Rep, 23 (11): (80). [PMID:34817709] |
| 3. Long D, Chen Y, Wu H, Zhao M, Lu Q. (2019) Clinical significance and immunobiology of IL-21 in autoimmunity.. J Autoimmun, 99 (1-14). [PMID:30773373] |
| 4. Parrish-Novak, J J and 37 more authors.. (2000) Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function.. Nature, (2): [PMID:11081504] |
| 5. Sivakumar, Pallavur V PV, Foster, Donald C DC and Clegg, Christopher H CH.. (2004) Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses.. Immunology, [PMID:15147560] |
| 6. Strengell, Mari M, Julkunen, Ilkka I and Matikainen, Sampsa S.. (2004) IFN-alpha regulates IL-21 and IL-21R expression in human NK and T cells.. Journal of leukocyte biology, [PMID:15178704] |
| 7. Bondensgaard, Kent K and 8 more authors.. (2007) The existence of multiple conformers of interleukin-21 directs engineering of a superpotent analogue.. The Journal of biological chemistry, (10): [PMID:17565991] |
| 8. Rahman, Mizanur M and 6 more authors.. (2007) Cloning and characterization of an isoform of interleukin-21.. FEBS letters, (21): [PMID:17673207] |
| 9. Hamming, Ole J OJ and 8 more authors.. (2012) Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R.. The Journal of biological chemistry, (16): [PMID:22235133] |
| 10. Salzer, Elisabeth E and 17 more authors.. (2014) Early-onset inflammatory bowel disease and common variable immunodeficiency-like disease caused by IL-21 deficiency.. The Journal of allergy and clinical immunology, [PMID:24746753] |