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Avizakimab (anti-IL-21)

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human)
  • 亚型: Human IgG1
  • 偶联: Unconjugated
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库存信息

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库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
Ab175460-100μg
100μg 现货 Stock Image
Ab175460-1mg
1mg 现货 Stock Image
Ab175460-5mg
5mg 现货 Stock Image
Ab175460-10mg
10mg 期货 Stock Image

基本信息

产品名称 Avizakimab (anti-IL-21)
别名 艾维奇单抗 | 阿维扎单抗(抗 IL-21)
英文别名 CVID11 antibody | IL 21 antibody | IL-21 antibody | Il21 antibody | IL21_HUMAN antibody | Interleukin 21 antibody | Interleukin-21 antibody | interleukin-21 isoform antibody | Interleukin21 antibody | OTTHUMP00000164088 antibody | Za11 antibody | CVID11 |
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 IL21
种属反应性 人(Human)
偶联 Unconjugated
作用类型 抑制剂

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG1
轻链亚型 kappa
SDS-PAGE 27.2 kDa (Light Chain) & 51.9 kDa (Heavy Chain), under reducing conditions; 187.5 kDa, under non-reducing conditions.
纯化方法 Protein A purified
纯度 >95%
物理外观 Liquid
储存缓冲液 Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH5.0.
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 2229685-51-0
分子类型 抗体

关联靶点(人)

IL21 Tbio 白细胞介素-21(Interleukin-21) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

Avizakimab (anti-IL-21) (Ab175460) - ELISA
Immobilized Human IL-21-Fc Tag at 2.0 μg/mL can bind Avizakimab (anti-IL-21) (Ab175460) with the EC₅₀ of 549.90 ng/mL.

Avizakimab (anti-IL-21) (Ab175460) - SEC
The purity of Avizakimab (anti-IL-21) (Ab175460) is more than 95% verified by HPLC.

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

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找到3个结果

批号(Lot Number) 证书类型 货号
ZJ24F0303744 分析证书 Ab175460
ZJ24F0303743 分析证书 Ab175460
ZJ24F0303742 分析证书 Ab175460

引用文献

1. Wang S, Wang J, Kumar V, Karnell JL, Naiman B, Gross PS, Rahman S, Zerrouki K, Hanna R, Morehouse C et al..  (2018)  IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE..  Nat Commun,  (1): (1758).  [PMID:29717110]
2. Satterthwaite AB.  (2021)  TLR7 Signaling in Lupus B Cells: New Insights into Synergizing Factors and Downstream Signals..  Curr Rheumatol Rep,  23  (11): (80).  [PMID:34817709]
3. Long D, Chen Y, Wu H, Zhao M, Lu Q.  (2019)  Clinical significance and immunobiology of IL-21 in autoimmunity..  J Autoimmun,  99  (1-14).  [PMID:30773373]
4. Parrish-Novak, J J and 37 more authors..  (2000)  Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function..  Nature,  (2): [PMID:11081504]
5. Sivakumar, Pallavur V PV, Foster, Donald C DC and Clegg, Christopher H CH..  (2004)  Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses..  Immunology,  [PMID:15147560]
6. Strengell, Mari M, Julkunen, Ilkka I and Matikainen, Sampsa S..  (2004)  IFN-alpha regulates IL-21 and IL-21R expression in human NK and T cells..  Journal of leukocyte biology,  [PMID:15178704]
7. Bondensgaard, Kent K and 8 more authors..  (2007)  The existence of multiple conformers of interleukin-21 directs engineering of a superpotent analogue..  The Journal of biological chemistry,  (10): [PMID:17565991]
8. Rahman, Mizanur M and 6 more authors..  (2007)  Cloning and characterization of an isoform of interleukin-21..  FEBS letters,  (21): [PMID:17673207]
9. Hamming, Ole J OJ and 8 more authors..  (2012)  Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R..  The Journal of biological chemistry,  (16): [PMID:22235133]
10. Salzer, Elisabeth E and 17 more authors..  (2014)  Early-onset inflammatory bowel disease and common variable immunodeficiency-like disease caused by IL-21 deficiency..  The Journal of allergy and clinical immunology,  [PMID:24746753]

溶液计算器