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Prezalumab (anti-B7-H2)

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human), 小鼠(Mouse), 食蟹猴(Cynomolgus monkey)
  • 亚型: Human IgG2SA
  • 偶联: Unconjugated
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货号 (SKU) 包装规格 是否现货 价格 数量
Ab170952-100μg
100μg 现货 Stock Image
Ab170952-1mg
1mg 现货 Stock Image
Ab170952-5mg
5mg 现货 Stock Image
Ab170952-10mg
10mg 期货 Stock Image

基本信息

产品名称 Prezalumab (anti-B7-H2)
别名 普瑞鲁单抗 | 普瑞沙鲁单抗(抗 B7-H2)
英文别名 B7 H2 antibody | B7 homolog 2 antibody | B7 homologue 2 antibody | B7 like protein Gl50 antibody | B7 related protein 1 antibody | B7-H2 antibody | B7-like protein Gl50 antibody | B7-related protein 1 antibody | B7H2 antibody | B7RP 1 antibody | B7RP-1 an
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 ICOSLG
种属反应性 人(Human),小鼠(Mouse),食蟹猴(Cynomolgus monkey)
偶联 Unconjugated

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG2SA
轻链亚型 kappa
SDS-PAGE 26.9 kDa (Light Chain) & 51.7 kDa (Heavy Chain), under reducing conditions; 172.0 kDa, under non-reducing conditions.
纯化方法 Protein A purified
纯度 >95%
物理外观 Liquid
储存缓冲液 Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 1523164-68-2
分子类型 抗体

关联靶点(人)

ICOSLG Tbio ICOS 配体(ICOS ligand) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

Prezalumab (anti-B7-H2) (Ab170952) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling B7-H2 (red) with Prezalumab (anti-B7-H2) (Ab170952). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Prezalumab (anti-B7-H2) (Ab170952) - SEC
The purity of Prezalumab (anti-B7-H2) (Ab170952) is more than 95% verified by HPLC.

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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找到5个结果

批号(Lot Number) 证书类型 货号
ZJ23F1001312 分析证书 Ab170952
ZJ23F1001311 分析证书 Ab170952
ZJ24F0911519 分析证书 Ab170952
ZJ24F0911517 分析证书 Ab170952
ZJ24F0911518 分析证书 Ab170952

引用文献

1. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O.  (1998)  Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro..  DNA Res,  (3): (169-76).  [PMID:9734811]
2. Ling, V V and 12 more authors..  (2000)  Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor..  Journal of immunology (Baltimore, Md. : 1950),  (15): [PMID:10657606]
3. Aicher, A A and 8 more authors..  (2000)  Characterization of human inducible costimulator ligand expression and function..  Journal of immunology (Baltimore, Md. : 1950),  (1): [PMID:10779774]
4. Hattori, M M and 64 more authors..  (2000)  The DNA sequence of human chromosome 21..  Nature,  (18): [PMID:10830953]
5. Wang, S S and 6 more authors..  (2000)  Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS..  Blood,  (15): [PMID:11023515]
6. Liu, Tao T and 6 more authors.. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry..  Journal of proteome research,  [PMID:16335952]
7. Ramagopal, Udupi A UA and 12 more authors..  (2017)  Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab..  Proceedings of the National Academy of Sciences of the United States of America,  (23): [PMID:28484017]

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