货号 (SKU)

包装规格

是否现货

价格

数量

Ab170882-100μg

100μg

现货

Ab170882-1mg

1mg

现货

Ab170882-5mg

5mg

现货

Ab170882-10mg

10mg

期货

基本信息

产品名称	Eldelumab (anti-CXCL10), C-X-C 矩阵趋化因子 10 抑制剂
别名	埃迪鲁单抗 \| 埃代鲁单抗（抗 CXCL10）
英文别名	Interferon gamma induced factor MOB1, mouse, homolog of antibody \| Interferon gamma induced protein 10 antibody \| 10 kDa interferon gamma induced protein antibody \| 10 kDa interferon gamma-induced protein antibody \| C X C motif chemokine 10 antibody \| C7
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	CXCL10
种属反应性	人(Human),恒河猴(Rhesus monkey)
偶联	Unconjugated
作用类型	抑制剂
作用机制	C-X-C 矩阵趋化因子 10 抑制剂

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	27.1 kDa (Light Chain) & 53.9 kDa (Heavy Chain), under reducing conditions; 182.8 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0.
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	946414-98-8
分子类型	抗体

关联靶点（人）

CXCL10 Tbio CXC 基序趋化因子 10(C-X-C motif chemokine 10) (0 活性数据)

点击查看靶蛋白信息： CXCL10

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

SEC: Eldelumab (anti-CXCL10) (Ab170882)

Eldelumab (anti-CXCL10) (Ab170882) - SEC
The purity of Eldelumab (anti-CXCL10) (Ab170882) is more than 95% verified by HPLC.

ELISA: Eldelumab (anti-CXCL10) (Ab170882)

Eldelumab (anti-CXCL10) (Ab170882) - ELISA
Immobilized Recombinant Human CXCL10/IP-10 Protein (rp170434) at 1.0 μg/mL can bind Eldelumab (anti-CXCL10) (Ab170882) with the EC₅₀ of 268.7 ng/mL.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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找到5个结果

批号(Lot Number)	证书类型	货号
ZJ23F1001471	分析证书	Ab170882
ZJ23F1001472	分析证书	Ab170882
ZJ24F1012846	分析证书	Ab170882
ZJ24F1012845	分析证书	Ab170882
ZJ24F1012844	分析证书	Ab170882

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引用文献

1. Loos T, Mortier A, Gouwy M, Ronsse I, Put W, Lenaerts JP, Van Damme J, Proost P. (2008) Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation.. Blood, 112 (7): (2648-56). [PMID:18645041]
2. Luster, A D AD, Unkeless, J C JC and Ravetch, J V JV.. (1985) Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins.. Nature, [PMID:3925348]
3. Angiolillo, A L AL and 8 more authors.. (1995) Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo.. The Journal of experimental medicine, (1): [PMID:7540647]
4. Proost, P P and 5 more authors.. (1993) Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:8423327]
5. Loetscher, M M and 7 more authors.. (1996) Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes.. The Journal of experimental medicine, (1): [PMID:9064356]
6. Tensen, C P CP and 8 more authors.. (1999) Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3).. The Journal of investigative dermatology, [PMID:10233762]
7. Romagnani, P P and 12 more authors.. (2001) Interferon-inducible protein 10, monokine induced by interferon gamma, and interferon-inducible T-cell alpha chemoattractant are produced by thymic epithelial cells and attract T-cell receptor (TCR) alphabeta+ CD8+ single-positive T cells, TCRgammadelta+ T cells, and natural killer-type cells in human thymus.. Blood, (1): [PMID:11157474]
8. Hensbergen, P J PJ and 8 more authors.. (2001) Processing of natural and recombinant CXCR3-targeting chemokines and implications for biological activity.. European journal of biochemistry, [PMID:11559369]
9. Booth, Valerie V, Keizer, David W DW, Kamphuis, Monique B MB, Clark-Lewis, Ian I and Sykes, Brian D BD.. (2002) The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions.. Biochemistry, (20): [PMID:12173928]
10. Cheeran, Maxim C-J MC, Hu, Shuxian S, Sheng, Wen S WS, Peterson, Phillip K PK and Lokensgard, James R JR.. (2003) CXCL10 production from cytomegalovirus-stimulated microglia is regulated by both human and viral interleukin-10.. Journal of virology, [PMID:12663757]
11. Swaminathan, G Jawahar GJ and 6 more authors.. (2003) Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine.. Structure (London, England : 1993), [PMID:12737818]
12. Smit, Martine J MJ and 6 more authors.. (2003) CXCR3-mediated chemotaxis of human T cells is regulated by a Gi- and phospholipase C-dependent pathway and not via activation of MEK/p44/p42 MAPK nor Akt/PI-3 kinase.. Blood, (15): [PMID:12750173]
13. Casrouge, Armanda A and 11 more authors.. (2011) Evidence for an antagonist form of the chemokine CXCL10 in patients chronically infected with HCV.. The Journal of clinical investigation, [PMID:21183794]
14. Sidahmed, Abubaker M E AM and 6 more authors.. (2012) CXCL10 contributes to p38-mediated apoptosis in primary T lymphocytes in vitro.. Cytokine, [PMID:22652417]
15. Han, Xuesheng X and Parker, Tory L TL.. (2017) Anti-inflammatory activity of clove (Eugenia caryophyllata) essential oil in human dermal fibroblasts.. Pharmaceutical biology, [PMID:28407719]

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Eldelumab (anti-CXCL10), C-X-C 矩阵趋化因子 10 抑制剂

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基本信息

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关联靶点（人）

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质检证书（CoA,COO,BSE/TSE 和分析图谱)

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引用文献

溶液计算器

摩尔浓度计算器

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Eldelumab (anti-CXCL10), C-X-C 矩阵趋化因子 10 抑制剂

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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