Enfortumab (anti-NECTIN4)

COA

级别和纯度:

≥95%(SDS-PAGE&SEC-HPLC)
见COA

应用:

Animal Model
ELISA
Flow Cytometry
Functional Assay

宿主种属: 人(Human)
种属反应性: 人(Human), 小鼠(Mouse)
亚型: Human IgG1
偶联: Unconjugated

有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货
Ab170877-100μg	100μg	现货
Ab170877-1mg	1mg	现货
Ab170877-5mg	5mg	现货
Ab170877-10mg	10mg	期货

查看相关系列

点击查看靶蛋白信息: NECTIN4

Accession#:Q96NY8 (2) Gene ID:81607 (3) NECTIN4 (3)

Skip to the end of the images gallery

Skip to the beginning of the images gallery

基本信息

产品名称	Enfortumab (anti-NECTIN4)
别名	恩诺单抗 \| 恩福妥单抗（抗 NECTIN4）
英文别名	DKFZp686K05193 antibody \| EDSS1 antibody \| Ig superfamily receptor LNIR antibody \| Nectin 4 antibody \| Nectin-4 antibody \| poliovirus receptor-related 4 antibody \| Processed poliovirus receptor-related protein 4 antibody \| PRR4 antibody \| pvrl4 antibody \|
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	NECTIN4
种属反应性	人(Human),小鼠(Mouse)
偶联	Unconjugated
作用类型	抑制剂

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	27.0 kDa (Light Chain) & 51.4 kDa (Heavy Chain), under reducing conditions; 179.0 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	1448664-46-7
分子类型	抗体

关联靶点（人）

NECTIN4 Tclin 连接蛋白-4(Nectin-4) (0 活性数据)

点击查看靶蛋白信息： NECTIN4

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Flow Cytometry: Enfortumab (anti-NECTIN4) (Ab170877)

Enfortumab (anti-NECTIN4) (Ab170877) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling NECTIN4 (red) with Enfortumab (anti-NECTIN4) (Ab170877). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Enfortumab (anti-NECTIN4) (Ab170877)

Enfortumab (anti-NECTIN4) (Ab170877) - SEC
The purity of Enfortumab (anti-NECTIN4) (Ab170877) is more than 95% verified by HPLC.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到3个结果

批号(Lot Number)	证书类型	货号
ZJ23F0800950	分析证书	Ab170877
ZJ24F1013131	分析证书	Ab170877
ZJ24F0607382	分析证书	Ab170877

技术文档和文章

流式细胞术实验方案

Categories: 实验方案（Protocols）

探索主题:

抗体流式细胞术流式抗体活性染料间接抗体标记

引用文献

1. McGregor BA, Sonpavde G. (2019) Enfortumab Vedotin, a fully human monoclonal antibody against Nectin 4 conjugated to monomethyl auristatin E for metastatic urothelial Carcinoma.. Expert Opin Investig Drugs, 28 (10): (821-826). [PMID:31526130]
2. Brancati F, Fortugno P, Bottillo I, Lopez M, Josselin E, Boudghene-Stambouli O, Agolini E, Bernardini L, Bellacchio E, Iannicelli M et al.. (2010) Mutations in PVRL4, encoding cell adhesion molecule nectin-4, cause ectodermal dysplasia-syndactyly syndrome.. Am J Hum Genet, 87 (2): (265-73). [PMID:20691405]
3. Reymond, N N and 5 more authors.. (2001) Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction.. The Journal of biological chemistry, (16): [PMID:11544254]
4. Fabre, Stephanie S and 6 more authors.. (2002) Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin 4 bind to the predicted C-C'-C"-D beta-strands of the nectin1 V domain.. The Journal of biological chemistry, (26): [PMID:12011057]
5. Fabre-Lafay, Stéphanie S and 5 more authors.. (2005) Nectin-4, a new serological breast cancer marker, is a substrate for tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM-17.. The Journal of biological chemistry, (20): [PMID:15784625]
6. Fabre-Lafay, Stéphanie S and 18 more authors.. (2007) Nectin-4 is a new histological and serological tumor associated marker for breast cancer.. BMC cancer, (2): [PMID:17474988]
7. Mühlebach, Michael D MD and 15 more authors.. (2011) Adherens junction protein nectin-4 is the epithelial receptor for measles virus.. Nature, (2): [PMID:22048310]
8. Harrison, Oliver J OJ and 10 more authors.. (2012) Nectin ectodomain structures reveal a canonical adhesive interface.. Nature structural & molecular biology, [PMID:22902367]
9. Zhang, Xiaoai X and 9 more authors.. (2013) Structure of measles virus hemagglutinin bound to its epithelial receptor nectin-4.. Nature structural & molecular biology, [PMID:23202587]

溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

浓度

体积

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

体积 1 (V1)

浓度 2 (C2)

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

Enfortumab (anti-NECTIN4)

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

技术文档和文章

相关产品

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器