首页
抗体
重组抗体
Tregalizumab (anti-CD4), T 细胞表面抗原 CD4 激动剂的激动剂

Tregalizumab (anti-CD4), T 细胞表面抗原 CD4 激动剂的激动剂

级别和纯度:

≥95%(SDS-PAGE&SEC-HPLC)
见COA

应用:

Animal Model
ELISA
Flow Cytometry
Functional Assay

宿主种属: 人(Human)
种属反应性: 人(Human), 小鼠(Mouse)
亚型: Human IgG1
偶联: Unconjugated

有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货
Ab170850-100μg	100μg	现货
Ab170850-1mg	1mg	现货
Ab170850-5mg	5mg	现货
Ab170850-10mg	10mg	期货

查看相关系列

点击查看靶蛋白信息: CD4

Accession#:P01730 (27) Cd4 (49) Gene ID:920 (27)

Skip to the end of the images gallery

Skip to the beginning of the images gallery

基本信息

产品名称	Tregalizumab (anti-CD4), T 细胞表面抗原 CD4 激动剂的激动剂
别名	曲利组单抗 \| 特瑞加珠单抗（抗 CD4）
英文别名	CD 4 antibody \| CD4 (L3T4) antibody \| CD4 antibody \| CD4 antigen (p55) antibody \| CD4 antigen antibody \| CD4 molecule antibody \| CD4 receptor antibody \| CD4+ Lymphocyte deficiency, included antibody \| CD4_HUMAN antibody \| CD4mut antibody \| L3T4 antibody \|
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	CD4
种属反应性	人(Human),小鼠(Mouse)
偶联	Unconjugated
作用类型	激动剂
作用机制	T 细胞表面抗原 CD4 激动剂的激动剂

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	27.2 kDa (Light Chain) & 51.5 kDa (Heavy Chain), under reducing conditions; 165.5 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	1207446-68-1
分子类型	抗体

关联靶点（人）

CD4 Tclin T 细胞表面糖蛋白 CD4(T-cell surface glycoprotein CD4) (0 活性数据)

点击查看靶蛋白信息： CD4

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Flow Cytometry: Tregalizumab (anti-CD4) (Ab170850)

Tregalizumab (anti-CD4) (Ab170850) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD4 with Tregalizumab (anti-CD4) (Ab170850) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).

Flow Cytometry: Tregalizumab (anti-CD4) (Ab170850)

Tregalizumab (anti-CD4) (Ab170850) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD4 (red) with Tregalizumab (anti-CD4) (Ab170850) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Tregalizumab (anti-CD4) (Ab170850)

Tregalizumab (anti-CD4) (Ab170850) - SEC
The purity of Tregalizumab (anti-CD4) (Ab170850) is more than 95% verified by HPLC.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到5个结果

批号(Lot Number)	证书类型	货号
ZJ23F1202087	分析证书	Ab170850
ZJ23F1202088	分析证书	Ab170850
ZJ24F1012876	分析证书	Ab170850
ZJ24F1012875	分析证书	Ab170850
ZJ24F1012874	分析证书	Ab170850

可替换产品

引用文献

1. Burkly LC, Olson D, Shapiro R, Winkler G, Rosa JJ, Thomas DW, Williams C, Chisholm P. (1992) Inhibition of HIV infection by a novel CD4 domain 2-specific monoclonal antibody. Dissecting the basis for its inhibitory effect on HIV-induced cell fusion.. J Immunol, 149 (5): (1779-87). [PMID:1380539]
2. Wilkinson RA, Pincus SH, Song K, Shepard JB, Weaver AJ, Labib ME, Teintze M.. (2013) Improved guanide compounds which bind the CXCR4 co-receptor and inhibit HIV-1 infection.. Bioorg Med Chem Lett, 23 (7): (2197-2201). [PMID:23434419] [10.1016/j.bmcl.2013.01.107]
3. Lumangtad LA, Bell TW.. (2020) The signal peptide as a new target for drug design.. Bioorg Med Chem Lett, 30 (10): (127115-127115). [PMID:32209293] [10.1016/j.bmcl.2020.127115]
4. Lumangtad LA,Claeys E,Hamal S,Intasiri A,Basrai C,Yen-Pon E,Beenfeldt D,Vermeire K,Bell TW. (2020) Syntheses and anti-HIV and human cluster of differentiation 4 (CD4) down-modulating potencies of pyridine-fused cyclotriazadisulfonamide (CADA) compounds.. Bioorg Med Chem, 28 (24): (115816-115816). [PMID:33181479] [10.1016/j.bmc.2020.115816]
5. Fomsgaard, A A, Hirsch, V M VM and Johnson, P R PR.. (1992) Cloning and sequences of primate CD4 molecules: diversity of the cellular receptor for simian immunodeficiency virus/human immunodeficiency virus.. European journal of immunology, [PMID:1425921]
6. Crise, B B and Rose, J K JK.. (1992) Identification of palmitoylation sites on CD4, the human immunodeficiency virus receptor.. The Journal of biological chemistry, (5): [PMID:1618861]
7. Wang, J H JH and 9 more authors.. (1990) Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains.. Nature, (29): [PMID:1701030]
8. Hodge, T W TW, Sasso, D R DR and McDougal, J S JS.. (1991) Humans with OKT4-epitope deficiency have a single nucleotide base change in the CD4 gene, resulting in substitution of TRP240 for ARG240.. Human immunology, [PMID:1708753]
9. Spellman, M W MW, Leonard, C K CK, Basa, L J LJ, Gelineo, I I and van Halbeek, H H.. (1991) Carbohydrate structures of recombinant soluble human CD4 expressed in Chinese hamster ovary cells.. Biochemistry, (5): [PMID:2001369]
10. Crise, B B, Buonocore, L L and Rose, J K JK.. (1990) CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor.. Journal of virology, [PMID:2214026]
11. Ryu, S E SE and 9 more authors.. (1990) Crystal structure of an HIV-binding recombinant fragment of human CD4.. Nature, (29): [PMID:2247146]
12. Carr, S A SA and 7 more authors.. (1989) Protein and carbohydrate structural analysis of a recombinant soluble CD4 receptor by mass spectrometry.. The Journal of biological chemistry, (15): [PMID:2592374]
13. Doyle, C C and Strominger, J L JL.. (1987) Interaction between CD4 and class II MHC molecules mediates cell adhesion.. Nature, [PMID:2823150]
14. Maddon, P J PJ and 5 more authors.. (1985) The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family.. Cell, [PMID:2990730]
15. Littman, D R DR, Maddon, P J PJ and Axel, R R.. (1988) Corrected CD4 sequence.. Cell, (18): [PMID:3263213]
16. Lusso, P P and 5 more authors.. (1994) CD4 is a critical component of the receptor for human herpesvirus 7: interference with human immunodeficiency virus.. Proceedings of the National Academy of Sciences of the United States of America, (26): [PMID:7909607]
17. Winkel, K K, Sotzik, F F, Vremec, D D, Cameron, P U PU and Shortman, K K.. (1994) CD4 and CD8 expression by human and mouse thymic dendritic cells.. Immunology letters, [PMID:8088877]
18. Aiken, C C, Konner, J J, Landau, N R NR, Lenburg, M E ME and Trono, D D.. (1994) Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain.. Cell, (11): [PMID:8124721]
19. Ansari-Lari, M A MA and 7 more authors.. (1996) A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13.. Genome research, [PMID:8723724]
20. Ansari-Lari, M A MA, Shen, Y Y, Muzny, D M DM, Lee, W W and Gibbs, R A RA.. (1997) Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.. Genome research, [PMID:9074930]
21. Wu, H H, Kwong, P D PD and Hendrickson, W A WA.. (1997) Dimeric association and segmental variability in the structure of human CD4.. Nature, (29): [PMID:9168119]
22. Kwong, P D PD and 5 more authors.. (1998) Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody.. Nature, (18): [PMID:9641677]
23. Zeitlmann, L L, Sirim, P P, Kremmer, E E and Kolanus, W W.. (2001) Cloning of ACP33 as a novel intracellular ligand of CD4.. The Journal of biological chemistry, (23): [PMID:11113139]
24. Fragoso, Roben R and 5 more authors.. (2003) Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:12517957]
25. Sharma, Deepak D and 7 more authors.. (2005) Protein minimization of the gp120 binding region of human CD4.. Biochemistry, (13): [PMID:16331979]
26. Löwenberg, Mark M and 7 more authors.. (2006) Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN.. EMBO reports, [PMID:16888650]
27. Bernstein, Helene B HB and 5 more authors.. (2006) CD4 expression on activated NK cells: ligation of CD4 induces cytokine expression and cell migration.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:16951326]
28. Lindwasser, O Wolf OW, Chaudhuri, Rittik R and Bonifacino, Juan S JS.. (2007) Mechanisms of CD4 downregulation by the Nef and Vpu proteins of primate immunodeficiency viruses.. Current molecular medicine, [PMID:17346169]
29. Garron, Marie-Line ML and 5 more authors.. (2008) Structural basis for the interaction between focal adhesion kinase and CD4.. Journal of molecular biology, (1): [PMID:18078954]
30. Wang, Xin Xiang XX and 7 more authors.. (2011) Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex.. Proceedings of the National Academy of Sciences of the United States of America, (20): [PMID:21900604]
31. Fernandes, Rosa Anita and 11 more authors.. (2019) Complete Multilineage CD4 Expression Defect Associated With Warts Due to an Inherited Homozygous CD4 Gene Mutation.. Frontiers in immunology, [PMID:31781092]

溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

浓度

体积

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

体积 1 (V1)

浓度 2 (C2)

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

Tregalizumab (anti-CD4), T 细胞表面抗原 CD4 激动剂的激动剂

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关产品

可替换产品

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器