货号 (SKU)

包装规格

是否现货

价格

数量

Ab170840-100μg

100μg

现货

Ab170840-1mg

1mg

现货

Ab170840-5mg

5mg

现货

Ab170840-10mg

10mg

期货

基本信息

产品名称	Codrituzumab (anti-GPC3), 糖蛋白 3 抗体
别名	考曲妥珠单抗 \| Codrituzumab（抗 GPC3）
英文别名	DGSX antibody \| Glypican proteoglycan 3 antibody \| Glypican-3 [Precursor] antibody \| Gpc3 antibody \| GPC3_HUMAN antibody \| GTR2 2 antibody \| GTR2-2 antibody \| Heparan sulphate proteoglycan antibody \| Intestinal protein OCI 5 antibody \| Intestinal protein
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	GPC3
种属反应性	人(Human)
偶联	Unconjugated
作用类型	抑制剂
作用机制	糖蛋白 3 抗体

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	28.4 kDa (Light Chain) & 52.6 kDa (Heavy Chain), under reducing conditions; 178.1 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	1365267-33-9
分子类型	抗体

关联靶点（人）

GPC3 Tbio 磷脂酰肌醇蛋白聚糖-3(Glypican-3) (0 活性数据)

点击查看靶蛋白信息： GPC3

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

ELISA: Codrituzumab (anti-GPC3) (Ab170840)

Codrituzumab (anti-GPC3) (Ab170840) - ELISA
Immobilized Human GPC3-his at 2 μg/mL can bind Codrituzumab (anti-GPC3) (Ab170840) with the EC₅₀ of 15.34 ng/mL.

SEC: Codrituzumab (anti-GPC3) (Ab170840)

Codrituzumab (anti-GPC3) (Ab170840) - SEC
The purity of Codrituzumab (anti-GPC3) (Ab170840) is more than 95% verified by HPLC.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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找到7个结果

批号(Lot Number)	证书类型	货号
ZJ25F0723624	分析证书	Ab170840
ZJ24F1113293	分析证书	Ab170840
ZJ24F1113292	分析证书	Ab170840
ZJ24F1113291	分析证书	Ab170840
ZJ24F0202858	分析证书	Ab170840
ZJ24F0202857	分析证书	Ab170840
ZJ24F0202856	分析证书	Ab170840

引用文献

1. Nakano K, Ishiguro T, Konishi H, Tanaka M, Sugimoto M, Sugo I, Igawa T, Tsunoda H, Kinoshita Y, Habu K et al.. (2010) Generation of a humanized anti-glypican 3 antibody by CDR grafting and stability optimization.. Anticancer Drugs, 21 (10): (907-16). [PMID:20847643]
2. Davoodi J, Kelly J, Gendron NH, MacKenzie AE. (2007) The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26.. Proteomics, 7 (13): (2300-10). [PMID:17549790]
3. Pilia, G G and 9 more authors.. (1996) Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome.. Nature genetics, [PMID:8589713]
4. Shen, T T and 6 more authors.. (1997) Mapping of the Simpson-Golabi-Behmel overgrowth syndrome gene (GPC3) to chromosome X in human and rat by fluorescence in situ hybridization.. Mammalian genome : official journal of the International Mammalian Genome Society, [PMID:9021160]
5. Lage, H H and Dietel, M M.. (1997) Cloning and characterization of human cDNAs encoding a protein with high homology to rat intestinal development protein OCI-5.. Gene, (1): [PMID:9133586]
6. Huber, R R and 8 more authors.. (1997) Analysis of exon/intron structure and 400 kb of genomic sequence surrounding the 5'-promoter and 3'-terminal ends of the human glypican 3 (GPC3) gene.. Genomics, (1): [PMID:9339360]
7. Veugelers, M M and 11 more authors.. (2000) Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene.. Human molecular genetics, (22): [PMID:10814714]
8. Capurro, Mariana M and 6 more authors.. (2003) Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma.. Gastroenterology, [PMID:12851874]
9. De Cat, Bart B and 8 more authors.. (2003) Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements.. The Journal of cell biology, (10): [PMID:14610063]
10. Hippo, Yoshitaka Y and 19 more authors.. (2004) Identification of soluble NH2-terminal fragment of glypican-3 as a serological marker for early-stage hepatocellular carcinoma.. Cancer research, (1): [PMID:15059894]
11. Ross, Mark T MT and 281 more authors.. (2005) The DNA sequence of the human X chromosome.. Nature, (17): [PMID:15772651]
12. Capurro, Mariana I MI, Xiang, Yun-Yan YY, Lobe, Corrinne C and Filmus, Jorge J.. (2005) Glypican-3 promotes the growth of hepatocellular carcinoma by stimulating canonical Wnt signaling.. Cancer research, (15): [PMID:16024626]
13. Capurro, Mariana I MI, Shi, Wen W, Sandal, Shaifali S and Filmus, Jorge J.. (2005) Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth.. The Journal of biological chemistry, (16): [PMID:16227623]
14. Capurro, Mariana M, Martin, Tonya T, Shi, Wen W and Filmus, Jorge J.. (2014) Glypican-3 binds to Frizzled and plays a direct role in the stimulation of canonical Wnt signaling.. Journal of cell science, (1): [PMID:24496449]
15. Capurro, Mariana M, Shi, Wen W, Izumikawa, Tomomi T, Kitagawa, Hiroshi H and Filmus, Jorge J.. (2015) Processing by convertases is required for glypican-3-induced inhibition of Hedgehog signaling.. The Journal of biological chemistry, (20): [PMID:25653284]
16. Tagliabracci, Vincent S VS and 14 more authors.. (2015) A Single Kinase Generates the Majority of the Secreted Phosphoproteome.. Cell, (18): [PMID:26091039]
17. Saad, Ahmad A and 7 more authors.. (2018) Role of Glycanation and Convertase Maturation of Soluble Glypican-3 in Inhibiting Proliferation of Hepatocellular Carcinoma Cells.. Biochemistry, (20): [PMID:29345911]

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Codrituzumab (anti-GPC3), 糖蛋白 3 抗体

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基本信息

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关联靶点（人）

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图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

引用文献

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Codrituzumab (anti-GPC3), 糖蛋白 3 抗体

库存信息

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库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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