货号 (SKU)

包装规格

是否现货

价格

数量

Ab170556-100μg

100μg

现货

Ab170556-1mg

1mg

现货

Ab170556-5mg

5mg

现货

Ab170556-10mg

10mg

期货

基本信息

产品名称	Simtuzumab (anti-LOXL2), 类赖氨酸氧化酶 2 抑制剂
别名	辛妥珠单抗（抗LOXL2）
英文别名	EC 1.4.3.13 \| Lysyl oxidase-like protein 2 \| Lysyl oxidase-related protein 2 \| Lysyl oxidase-related protein WS9-14
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	LOXL2
应用	ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR),Flow Cyt
种属反应性	人(Human),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated
作用类型	抑制剂
作用机制	类赖氨酸氧化酶 2 抑制剂

产品属性

抗体类型	Primary antibody
克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG4SP
轻链亚型	kappa
SDS-PAGE	27.3 kDa (Light Chain) & 52.7 kDa (Heavy Chain), under reducing conditions; 180.0 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
来源	CHO supernatant
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	1318075-13-6
分子类型	抗体

关联靶点（人）

LOXL2 Tchem 赖氨酰氧化酶同源物 2(Lysyl oxidase homolog 2) (0 活性数据)

点击查看靶蛋白信息： LOXL2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

ELISA: Simtuzumab (anti-LOXL2) (Ab170556)

Simtuzumab (anti-LOXL2) (Ab170556) - ELISA
Immobilized hu-LOXL2-his at 2 μg/mL can bind Simtuzumab (anti-LOXL2) (Ab170556) with the EC₅₀ of 38.57 ng/mL.

SEC: Simtuzumab (anti-LOXL2) (Ab170556)

Simtuzumab (anti-LOXL2) (Ab170556) - SEC
The purity of Simtuzumab (anti-LOXL2) (Ab170556) is more than 95% verified by HPLC.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到5个结果

批号(Lot Number)	证书类型	货号
ZJ23F1001456	分析证书	Ab170556
ZJ23F1001455	分析证书	Ab170556
ZJ24F1012783	分析证书	Ab170556
ZJ24F1012782	分析证书	Ab170556
ZJ24F1012781	分析证书	Ab170556

引用文献

1. Rodriguez HM, Vaysberg M, Mikels A, McCauley S, Velayo AC, Garcia C, Smith V. (2010) Modulation of lysyl oxidase-like 2 enzymatic activity by an allosteric antibody inhibitor.. J Biol Chem, 285 (27): (20964-74). [PMID:20439985]
2. Nishioka T, Eustace A, West C. (2012) Lysyl oxidase: from basic science to future cancer treatment.. Cell Struct Funct, 37 (1): (75-80). [PMID:22453058]
3. Cano A, Santamaría PG, Moreno-Bueno G. (2012) LOXL2 in epithelial cell plasticity and tumor progression.. Future Oncol, 8 (9): (1095-108). [PMID:23030485]
4. Adamali HI, Maher TM. (2012) Current and novel drug therapies for idiopathic pulmonary fibrosis.. Drug Des Devel Ther, 6 (261-72). [PMID:23055696]
5. Tadmor T, Bejar J, Attias D, Mischenko E, Sabo E, Neufeld G, Vadasz Z. (2013) The expression of lysyl-oxidase gene family members in myeloproliferative neoplasms.. Am J Hematol, 88 (5): (355-8). [PMID:23494965]
6. Van Bergen T, Marshall D, Van de Veire S, Vandewalle E, Moons L, Herman J, Smith V, Stalmans I. (2013) The role of LOX and LOXL2 in scar formation after glaucoma surgery.. Invest Ophthalmol Vis Sci, 54 (8): (5788-96). [PMID:23821193]
7. Chien JW, Richards TJ, Gibson KF, Zhang Y, Lindell KO, Shao L, Lyman SK, Adamkewicz JI, Smith V, Kaminski N et al.. (2014) Serum lysyl oxidase-like 2 levels and idiopathic pulmonary fibrosis disease progression.. Eur Respir J, 43 (5): (1430-8). [PMID:24177001]
8. Martin A, Salvador F, Moreno-Bueno G, Floristán A, Ruiz-Herguido C, Cuevas EP, Morales S, Santos V, Csiszar K, Dubus P et al.. (2015) Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.. EMBO J, 34 (8): (1090-109). [PMID:25759215]
9. Smithen DA, Leung LMH, Challinor M, Lawrence R, Tang H, Niculescu-Duvaz D, Pearce SP, Mcleary R, Lopes F, Aljarah M et al.. (2020) 2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth.. J Med Chem, 63 (5): (2308-2324). [PMID:31430136]
10. Barker HE, Chang J, Cox TR, Lang G, Bird D, Nicolau M, Evans HR, Gartland A, Erler JT. (2011) LOXL2-mediated matrix remodeling in metastasis and mammary gland involution.. Cancer Res, 71 (5): (1561-72). [PMID:21233336]
11. Hajdú I, Kardos J, Major B, Fabó G, Lőrincz Z, Cseh S, Dormán G.. (2018) Inhibition of the LOX enzyme family members with old and new ligands. Selectivity analysis revisited.. Bioorg Med Chem Lett, 28 (18): (3113-3118). [PMID:30098867] [10.1016/j.bmcl.2018.07.001]
12. Saito, H H, Papaconstantinou, J J, Sato, H H and Goldstein, S S.. (1997) Regulation of a novel gene encoding a lysyl oxidase-related protein in cellular adhesion and senescence.. The Journal of biological chemistry, (28): [PMID:9079631]
13. Jourdan-Le Saux, C C and 5 more authors.. (1999) The LOXL2 gene encodes a new lysyl oxidase-like protein and is expressed at high levels in reproductive tissues.. The Journal of biological chemistry, (30): [PMID:10212285]
14. Peinado, Héctor H and 8 more authors.. (2005) A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression.. The EMBO journal, (5): [PMID:16096638]
15. Nusbaum, Chad C and 75 more authors.. (2006) DNA sequence and analysis of human chromosome 8.. Nature, (19): [PMID:16421571]
16. Schietke, Ruth R and 10 more authors.. (2010) The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1.. The Journal of biological chemistry, (26): [PMID:20026874]
17. Kim, Young-Mi YM, Kim, Eun-Cheol EC and Kim, Youngho Y.. (2011) The human lysyl oxidase-like 2 protein functions as an amine oxidase toward collagen and elastin.. Molecular biology reports, [PMID:20306300]
18. Barry-Hamilton, Vivian V and 22 more authors.. (2010) Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment.. Nature medicine, [PMID:20818376]
19. Moreno-Bueno, Gema G and 16 more authors.. (2011) Lysyl oxidase-like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas.. EMBO molecular medicine, [PMID:21732535]
20. Bignon, Marine M and 15 more authors.. (2011) Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane.. Blood, (6): [PMID:21835952]
21. Lugassy, Jennie J and 6 more authors.. (2012) The enzymatic activity of lysyl oxidas-like-2 (LOXL2) is not required for LOXL2-induced inhibition of keratinocyte differentiation.. The Journal of biological chemistry, (27): [PMID:22157764]
22. Li, Tian-Yu TY and 8 more authors.. (2012) Reduced nuclear and ectopic cytoplasmic expression of lysyl oxidase-like 2 is associated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma.. Human pathology, [PMID:22204712]
23. Xu, Li L and 7 more authors.. (2013) Post-translational modifications of recombinant human lysyl oxidase-like 2 (rhLOXL2) secreted from Drosophila S2 cells.. The Journal of biological chemistry, (22): [PMID:23319596]
24. Millanes-Romero, Alba A and 8 more authors.. (2013) Regulation of heterochromatin transcription by Snail1/LOXL2 during epithelial-to-mesenchymal transition.. Molecular cell, (12): [PMID:24239292]
25. Cuevas, Eva P EP and 5 more authors.. (2014) LOXL2 catalytically inactive mutants mediate epithelial-to-mesenchymal transition.. Biology open, (15): [PMID:24414204]
26. Iturbide, Ane A and 6 more authors.. (2015) LOXL2 Oxidizes Methylated TAF10 and Controls TFIID-Dependent Genes during Neural Progenitor Differentiation.. Molecular cell, (4): [PMID:25959397]
27. Sasaki, Takako T and 10 more authors.. (2016) Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa.. Matrix biology : journal of the International Society for Matrix Biology, [PMID:27339457]
28. Herranz, Nicolás N and 12 more authors.. (2016) Lysyl oxidase-like 2 (LOXL2) oxidizes trimethylated lysine 4 in histone H3.. The FEBS journal, [PMID:27735137]
29. Cuevas, Eva P EP and 6 more authors.. (2017) LOXL2 drives epithelial-mesenchymal transition via activation of IRE1-XBP1 signalling pathway.. Scientific reports, (23): [PMID:28332555]
30. Zhang, Xi X and 5 more authors.. (2018) Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a precursor state.. Proceedings of the National Academy of Sciences of the United States of America, (10): [PMID:29581294]

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Simtuzumab (anti-LOXL2), 类赖氨酸氧化酶 2 抑制剂

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基本信息

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关联靶点（人）

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质检证书（CoA,COO,BSE/TSE 和分析图谱)

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器

Simtuzumab (anti-LOXL2), 类赖氨酸氧化酶 2 抑制剂

库存信息

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库存信息

基本信息

产品属性

关联靶点（人）

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图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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引用文献

溶液计算器

摩尔浓度计算器

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