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Sotigalimab (anti-CD40), 肿瘤坏死因子受体超家族成员 5 激动剂的激动剂

Sotigalimab (anti-CD40), 肿瘤坏死因子受体超家族成员 5 激动剂的激动剂

级别和纯度:

≥95%(SDS-PAGE&SEC-HPLC)
见COA

应用:

Animal Model
ELISA
Flow Cytometry
Functional Assay

宿主种属: 人(Human)
种属反应性: 人(Human), 食蟹猴(Cynomolgus monkey)
亚型: Human IgG1
偶联: Unconjugated

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货号 (SKU)	包装规格	是否现货
Ab170552-100μg	100μg	现货
Ab170552-1mg	1mg	现货
Ab170552-5mg	5mg	现货
Ab170552-10mg	10mg	期货

查看相关系列

点击查看靶蛋白信息: CD40

Accession#:P25942 (34) CD40 (40) Extrinsic Pathway (1228) Gene ID:958 (33)

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基本信息

产品名称	Sotigalimab (anti-CD40), 肿瘤坏死因子受体超家族成员 5 激动剂的激动剂
别名	索替加利单抗（抗 CD40）
英文别名	B-cell surface antigen CD40 \| Bp50 \| CD40L receptor \| CDw40
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	CD40
应用	ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR),Flow Cyt
种属反应性	人(Human),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated
作用类型	激动剂
作用机制	肿瘤坏死因子受体超家族成员 5 激动剂的激动剂

产品属性

抗体类型	Primary antibody
克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	144.54 kDa
纯化方法	Protein A purified
纯度	>95%
来源	CHO supernatant
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	2305607-45-6
分子类型	抗体

关联靶点（人）

CD40 Tchem 肿瘤坏死因子受体超家族成员 5(Tumor necrosis factor receptor superfamily member 5) (0 活性数据)

点击查看靶蛋白信息： CD40

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

CD40 Tchem Tumor necrosis factor receptor superfamily member 5 (9 活性数据)

点击查看靶蛋白信息： CD40

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Flow Cytometry: Sotigalimab (anti-CD40) (Ab170552)

Sotigalimab (anti-CD40) (Ab170552) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD40 with Sotigalimab (anti-CD40) (Ab170552) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).

Flow Cytometry: Ab170552 Sotigalimab (anti-CD40)

Sotigalimab (anti-CD40) (Ab170552) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD40 (red) with Sotigalimab (anti-CD40) (Ab170552) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Sotigalimab (anti-CD40) (Ab170552)

Sotigalimab (anti-CD40) (Ab170552) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD40 (red) with Sotigalimab (anti-CD40) (Ab170552). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Ab170552 Sotigalimab (anti-CD40)

Sotigalimab (anti-CD40) (Ab170552) - SEC
The purity of Sotigalimab (anti-CD40) (Ab170552) is more than 95% verified by HPLC.

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C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到5个结果

批号(Lot Number)	证书类型	货号
ZJ23F1001491	分析证书	Ab170552
ZJ23F1001492	分析证书	Ab170552
ZJ24F0911241	分析证书	Ab170552
ZJ24F0911240	分析证书	Ab170552
ZJ24F0911239	分析证书	Ab170552

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引用文献

1. Chen J, Song Y, Bojadzic D, Tamayo-Garcia A, Landin AM, Blomberg BB, Buchwald P.. (2017) Small-Molecule Inhibitors of the CD40-CD40L Costimulatory Protein-Protein Interaction.. J Med Chem, 60 (21): (8906-8922). [PMID:29024591] [10.1021/acs.jmedchem.7b01154]
2. Braesch-Andersen, S S and 5 more authors.. (1989) Biochemical characteristics and partial amino acid sequence of the receptor-like human B cell and carcinoma antigen CDw40.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:2463309]
3. Stamenkovic, I I, Clark, E A EA and Seed, B B.. (1989) A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.. The EMBO journal, [PMID:2475341]
4. Sato, T T, Irie, S S and Reed, J C JC.. (1995) A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40.. FEBS letters, (23): [PMID:7530216]
5. Cheng, G G and 5 more authors.. (1995) Involvement of CRAF1, a relative of TRAF, in CD40 signaling.. Science (New York, N.Y.), (10): [PMID:7533327]
6. Bajorath, J J and Aruffo, A A.. (1997) Construction and analysis of a detailed three-dimensional model of the ligand binding domain of the human B cell receptor CD40.. Proteins, [PMID:9037712]
7. Kashiwada, M M and 8 more authors.. (1998) Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signaling along a ras-independent pathway.. The Journal of experimental medicine, (19): [PMID:9432981]
8. Mizushima, S S and 8 more authors.. (1998) Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5).. Gene, (30): [PMID:9511754]
9. Singh, J J and 7 more authors.. (1998) The role of polar interactions in the molecular recognition of CD40L with its receptor CD40.. Protein science : a publication of the Protein Society, [PMID:9605317]
10. Pullen, S S SS and 5 more authors.. (1998) CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization.. Biochemistry, (25): [PMID:9718306]
11. Ni, C Z CZ and 6 more authors.. (2000) Molecular basis for CD40 signaling mediated by TRAF3.. Proceedings of the National Academy of Sciences of the United States of America, (12): [PMID:10984535]
12. Tone, M M, Tone, Y Y, Fairchild, P J PJ, Wykes, M M and Waldmann, H H.. (2001) Regulation of CD40 function by its isoforms generated through alternative splicing.. Proceedings of the National Academy of Sciences of the United States of America, (13): [PMID:11172023]
13. Ferrari, S S and 15 more authors.. (2001) Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM.. Proceedings of the National Academy of Sciences of the United States of America, (23): [PMID:11675497]
14. Khandekar, S S SS and 9 more authors.. (2001) Determination of carbohydrate structures N-linked to soluble CD154 and characterization of the interactions of CD40 with CD154 expressed in Pichia pastoris and Chinese hamster ovary cells.. Protein expression and purification, [PMID:11676606]
15. Li, Chenglong C and 9 more authors.. (2002) Downstream regulator TANK binds to the CD40 recognition site on TRAF3.. Structure (London, England : 1993), [PMID:12005438]
16. Tai, Yu-Tzu YT and 13 more authors.. (2004) Mechanisms by which SGN-40, a humanized anti-CD40 antibody, induces cytotoxicity in human multiple myeloma cells: clinical implications.. Cancer research, (15): [PMID:15087402]
17. Ouadani, Hanen H and 14 more authors.. (2016) Novel and recurrent AID mutations underlie prevalent autosomal recessive form of HIGM in consanguineous patients.. Immunogenetics, [PMID:26545377]
18. Takada, Yoko K; Yu, Jessica; Shimoda, Michiko and Takada, Yoshikazu.. (2019) Integrin Binding to the Trimeric Interface of CD40L Plays a Critical Role in CD40/CD40L Signaling.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:31331973]

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Sotigalimab (anti-CD40), 肿瘤坏死因子受体超家族成员 5 激动剂的激动剂

库存信息

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基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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引用文献

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