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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab170542-100μg |
100μg |
现货 ![]() |
| |
| Ab170542-1mg |
1mg |
现货 ![]() |
| |
| Ab170542-5mg |
5mg |
现货 ![]() |
| |
| Ab170542-10mg |
10mg |
期货 ![]() |
|
| 产品名称 | Blosozumab (anti-SOST), 硬骨蛋白抑制剂的抑制剂 |
|---|---|
| 别名 | 布洛索单抗(抗社会变革病毒) |
| 英文别名 | Blosozumab | BEER antibody | CDD antibody | Cortical hyperostosis with syndactyly antibody | Sclerosteosis antibody | Sclerostin antibody | Sost antibody | SOST_HUMAN antibody | SOST1 antibody | UNQ2976/PRO7455/PRO7476 antibody | VBCH antibody | sclerosti |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA |
| 宿主种属 | 人(Human) |
| 特异性 | SOST |
| 应用 | ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) |
| 种属反应性 | 人(Human),大鼠(Rat),食蟹猴(Cynomolgus monkey) |
| 偶联 | Unconjugated |
| 作用类型 | 抑制剂 |
| 作用机制 | 硬骨蛋白抑制剂的抑制剂 |
| 抗体类型 | Primary antibody |
|---|---|
| 克隆类型 | 重组抗体 |
| Format | Whole IgG |
| 亚型 | Human IgG4SP |
| 轻链亚型 | kappa |
| SDS-PAGE | 26.6 kDa (Light Chain) & 53.9 kDa (Heavy Chain), under reducing conditions; 183.0 kDa, under non-reducing conditions. |
| 纯化方法 | Protein A purified |
| 纯度 | >95% |
| 来源 | CHO supernatant |
| 物理外观 | Liquid |
| 储存缓冲液 | Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | 见COA |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。 |
| CAS编号和信息 | 1132758-87-2 |
| 分子类型 | 抗体 |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
Blosozumab (anti-SOST) (Ab170542) - SEC
The purity of Blosozumab (anti-SOST) (Ab170542) is more than 95% verified by HPLC.
通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | Ab170542 | |
| 分析证书 | Ab170542 | |
| 分析证书 | Ab170542 | |
| 分析证书 | Ab170542 | |
| 分析证书 | Ab170542 |
¥669.90
| 1. Brunkow, M E ME and 17 more authors.. (2001) Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein.. American journal of human genetics, [PMID:11179006] |
| 2. Balemans, W W and 20 more authors.. (2001) Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST).. Human molecular genetics, (1): [PMID:11181578] |
| 3. Balemans, W W and 14 more authors.. (2002) Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease.. Journal of medical genetics, [PMID:11836356] |
| 4. Semënov, Mikhail M, Tamai, Keiko K and He, Xi X.. (2005) SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor.. The Journal of biological chemistry, (22): [PMID:15908424] |
| 5. Veverka, Vaclav V and 15 more authors.. (2009) Characterization of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation.. The Journal of biological chemistry, (17): [PMID:19208630] |
| 6. Didangelos, Athanasios A and 5 more authors.. (2010) Proteomics characterization of extracellular space components in the human aorta.. Molecular & cellular proteomics : MCP, [PMID:20551380] |
| 7. Piters, Elke E and 12 more authors.. (2010) First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function.. Human mutation, [PMID:20583295] |
| 8. Kim, Su Jin SJ and 16 more authors.. (2011) Identification of signal peptide domain SOST mutations in autosomal dominant craniodiaphyseal dysplasia.. Human genetics, [PMID:21221996] |
| 9. Leupin, Olivier O and 21 more authors.. (2011) Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function.. The Journal of biological chemistry, (3): [PMID:21471202] |
| 10. Langdahl, Bente L BL and 21 more authors.. (2017) Romosozumab (sclerostin monoclonal antibody) versus teriparatide in postmenopausal women with osteoporosis transitioning from oral bisphosphonate therapy: a randomised, open-label, phase 3 trial.. Lancet (London, England), (30): [PMID:28755782] |