货号 (SKU)

包装规格

是否现货

价格

数量

Ab170536-100μg

100μg

现货

Ab170536-1mg

1mg

现货

Ab170536-5mg

5mg

现货

Ab170536-10mg

10mg

期货

基本信息

产品名称	Nesvacumab (anti-ANGPT2), 血管生成素-2 抑制剂
别名	奈伐单抗（抗-AGPT2）
英文别名	Anti-ANGPT2 Reference Antibody (nesvacumab) \| nesvacumab \| AGPT 2 antibody \| Agpt2 antibody \| ANG 2 antibody \| ANG-2 antibody \| ANG2 antibody \| Angiopoietin 2a antibody \| Angiopoietin 2B antibody \| Angiopoietin-2 antibody \| Angiopoietin2 antibody \| ANGP2_
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	ANGPT2
应用	ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
种属反应性	人(Human),小鼠(Mouse),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated
作用类型	抑制剂
作用机制	血管生成素-2 抑制剂

产品属性

抗体类型	Primary antibody
克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	25.9 kDa (Light Chain) & 50.1 kDa (Heavy Chain), under reducing conditions; 177.2 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
来源	CHO supernatant
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	1296818-77-3
分子类型	抗体

关联靶点（人）

ANGPT2 Tclin 血管生成素-2(Angiopoietin-2) (0 活性数据)

点击查看靶蛋白信息： ANGPT2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

ELISA: Nesvacumab (anti-ANGPT2) (Ab170536)

Nesvacumab (anti-ANGPT2) (Ab170536) - ELISA
Immobilized human ANGPT2 at 2.0 μg/mL can bind Nesvacumab (anti-ANGPT2) (Ab170536) with the EC₅₀ of 19.65 ng/mL.

SEC: Nesvacumab (anti-ANGPT2) (Ab170536)

Nesvacumab (anti-ANGPT2) (Ab170536) - SEC
The purity of Nesvacumab (anti-ANGPT2) (Ab170536) is more than 95% verified by HPLC.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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找到3个结果

批号(Lot Number)	证书类型	货号
ZJ24F0303687	分析证书	Ab170536
ZJ24F0303686	分析证书	Ab170536
ZJ24F0303685	分析证书	Ab170536

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引用文献

1. Daly C, Eichten A, Castanaro C, Pasnikowski E, Adler A, Lalani AS, Papadopoulos N, Kyle AH, Minchinton AI, Yancopoulos GD et al.. (2013) Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition.. Cancer Res, 73 (1): (108-18). [PMID:23149917]
2. Gerald D, Chintharlapalli S, Augustin HG, Benjamin LE. (2013) Angiopoietin-2: an attractive target for improved antiangiogenic tumor therapy.. Cancer Res, 73 (6): (1649-57). [PMID:23467610]
3. Regula JT, Lundh von Leithner P, Foxton R, Barathi VA, Cheung CM, Bo Tun SB, Wey YS, Iwata D, Dostalek M, Moelleken J et al.. (2016) Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases.. EMBO Mol Med, 8 (11): (1265-1288). [PMID:27742718]
4. Maisonpierre, P C PC and 13 more authors.. (1997) Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.. Science (New York, N.Y.), (4): [PMID:9204896]
5. Tanaka, S S and 5 more authors.. (1999) Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma.. The Journal of clinical investigation, [PMID:9927494]
6. Kim, I I and 5 more authors.. (2000) Characterization and expression of a novel alternatively spliced human angiopoietin-2.. The Journal of biological chemistry, (16): [PMID:10766762]
7. Fiedler, Ulrike U and 8 more authors.. (2003) Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats.. The Journal of biological chemistry, (17): [PMID:12427764]
8. Lee, Hyuek Jong HJ and 9 more authors.. (2004) Biological characterization of angiopoietin-3 and angiopoietin-4.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, [PMID:15284220]
9. Barton, William A WA, Tzvetkova, Dorothea D and Nikolov, Dimitar B DB.. (2005) Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition.. Structure (London, England : 1993), [PMID:15893672]
10. Nusbaum, Chad C and 75 more authors.. (2006) DNA sequence and analysis of human chromosome 8.. Nature, (19): [PMID:16421571]
11. Barton, William A WA and 6 more authors.. (2006) Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex.. Nature structural & molecular biology, [PMID:16732286]
12. Yacyshyn, Orisha K OK and 5 more authors.. (2009) Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells.. Angiogenesis, [PMID:19116766]
13. Yuan, Hai Tao HT, Khankin, Eliyahu V EV, Karumanchi, S Ananth SA and Parikh, Samir M SM.. (2009) Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium.. Molecular and cellular biology, [PMID:19223473]
14. Leppänen, Veli-Matti and 20 more authors.. (2020) Characterization of ANGPT2 mutations associated with primary lymphedema.. Science translational medicine, (9): [PMID:32908006]

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Nesvacumab (anti-ANGPT2), 血管生成素-2 抑制剂

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基本信息

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关联靶点（人）

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质检证书（CoA,COO,BSE/TSE 和分析图谱)

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引用文献

溶液计算器

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Nesvacumab (anti-ANGPT2), 血管生成素-2 抑制剂

库存信息

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库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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引用文献

溶液计算器

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