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Abituzumab (anti-ITGAV), Integrin alpha-V/beta-1 抑制剂

Abituzumab (anti-ITGAV), Integrin alpha-V/beta-1 抑制剂

1篇引用文献

级别和纯度:

≥95%(SDS-PAGE&SEC-HPLC)
见COA

应用:

Animal Model
ELISA
Flow Cytometry
Functional Assay

宿主种属: 人(Human)
种属反应性: 人(Human)
亚型: Human IgG2
偶联: Unconjugated

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货号 (SKU)	包装规格	是否现货
Ab170472-100μg	100μg	现货
Ab170472-1mg	1mg	现货
Ab170472-5mg	5mg	现货
Ab170472-10mg	10mg	期货

查看相关系列

点击查看靶蛋白信息: ITGAV

Accession#:P06756 (5) Gene ID:3685 (5) Integrin alpha V (4) ITGAV (5)

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基本信息

产品名称	Abituzumab (anti-ITGAV), Integrin alpha-V/beta-1 抑制剂
别名	阿比妥珠单抗 \| 阿比珠单抗（抗 ITGAV）
英文别名	Abituzumab \| antigen identified by monoclonal antibody L230 antibody \| CD 51 antibody \| CD51 antibody \| DKFZp686A08142 antibody \| Integrin alpha five antibody \| integrin alpha V beta 3 antibody \| Integrin alpha-5 antibody \| integrin alpha-V antibody \| Int
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	ITGAV
应用	ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
种属反应性	人(Human)
偶联	Unconjugated
作用类型	抑制剂
作用机制	Integrin alpha-V/beta-1 抑制剂

产品属性

抗体类型	Primary antibody
克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG2
轻链亚型	kappa
SDS-PAGE	27.2 kDa (Light Chain) & 52.6 kDa (Heavy Chain), under reducing conditions; 175.0 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
来源	CHO supernatant
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	1105038-73-0
分子类型	抗体

关联靶点（人）

ITGAV Tchem 整合素α-V(Integrin alpha-V) (0 活性数据)

点击查看靶蛋白信息： ITGAV

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

ITGAV Tchem Vitronectin receptor alpha (65 活性数据)

点击查看靶蛋白信息： ITGAV

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

ITGAV Tchem Integrin alpha-V/beta-5 (589 活性数据)

点击查看靶蛋白信息： ITGAV

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

ITGAV Tchem Integrin alpha-V/beta-6 (509 活性数据)

点击查看靶蛋白信息： ITGAV

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

ITGAV Tchem Integrin alpha-V/beta-8 (181 活性数据)

点击查看靶蛋白信息： ITGAV

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Flow Cytometry: Abituzumab (anti-ITGAV) (Ab170472)

Abituzumab (anti-ITGAV) (Ab170472) - Flow Cytometry
Flow Cytometry analysis of A549 cells labelling ITGAV (red) with Abituzumab (anti-ITGAV) (Ab170472). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Abituzumab (anti-ITGAV) (Ab170472)

Abituzumab (anti-ITGAV) (Ab170472) - SEC
The purity of Abituzumab (anti-ITGAV) (Ab170472) is more than 95% verified by HPLC.

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C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

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找到4个结果

批号(Lot Number)	证书类型	货号
ZJ23F0900974	分析证书	Ab170472
ZJ23F0900973	分析证书	Ab170472
ZJ24F1012840	分析证书	Ab170472
ZJ24F1012839	分析证书	Ab170472

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引用文献

1. Miller WH, Bondinell WE, Cousins RD, Erhard KF, Jakas DR, Keenan RM, Ku TW, Newlander KA, Ross ST, Haltiwanger RC, Bradbeer J, Drake FH, Gowen M, Hoffman SJ, Hwang SM, James IE, Lark MW, Lechowska B, Rieman DJ, Stroup GB, Vasko-Moser JA, Zembryki DL, Azzarano LM, Adams PC, Huffman WF.. (1999) Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model.. Bioorg Med Chem Lett, 9 (13): (1807-1812). [PMID:10406646] [10.1016/s0960-894x(99)00283-8]
2. Urbahns K, Härter M, Vaupel A, Albers M, Schmidt D, Brüggemeier U, Stelte-Ludwig B, Gerdes C, Tsujishita H.. (2003) Biphenyls as potent vitronectin receptor antagonists. Part 2: biphenylalanine ureas.. Bioorg Med Chem Lett, 13 (6): (1071-1074). [PMID:12643914] [10.1016/s0960-894x(03)00023-4]
3. Vallon M, Essler M. (2006) Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans.. J Biol Chem, 281 (45): (34179-88). [PMID:16982628]
4. Yao N, Xiao W, Wang X, Marik J, Park SH, Takada Y, Lam KS. (2009) Discovery of targeting ligands for breast cancer cells using the one-bead one-compound combinatorial method.. J Med Chem, 52 (1): (126-33). [PMID:19055415]
5. Derkach DN, Wadekar SA, Perkins KB, Rousseau E, Dreiza CM, Cheung-Flynn J, Ramos HC, Ugarova TP, Sheller MR. (2010) RGD-dependent binding of TP508 to integrin alphavbeta3 mediates cell adhesion and induction of nitric oxide.. Thromb Haemost, 104 (1): (172-82). [PMID:20508901]
6. Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG et al.. (2013) Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs.. Nat Med, 19 (12): (1617-24). [PMID:24216753]
7. Anderson NA, Campos S, Butler S, Copley RCB, Duncan I, Harrison S, Le J, Maghames R, Pastor-Garcia A, Pritchard JM et al.. (2019) Discovery of an Orally Bioavailable Pan αv Integrin Inhibitor for Idiopathic Pulmonary Fibrosis.. J Med Chem, 62 (19): (8796-8808). [PMID:31497959]
8. Raboisson P, Desjarlais RL, Reed R, Lattanze J, Chaikin M, Manthey CL, Tomczuk BE, Marugán JJ.. (2007) Identification of novel short chain 4-substituted indoles as potent alphavbeta3 antagonist using structure-based drug design.. Eur J Med Chem, 42 (3): (334-343). [PMID:17184884] [10.1016/j.ejmech.2006.10.015]
9. Hall PR, Leitão A, Ye C, Kilpatrick K, Hjelle B, Oprea TI, Larson RS.. (2010) Small molecule inhibitors of hantavirus infection.. Bioorg Med Chem Lett, 20 (23): (7085-7091). [PMID:20951038] [10.1016/j.bmcl.2010.09.092]
10. Alloatti D, Giannini G, Vesci L, Castorina M, Pisano C, Badaloni E, Cabri W.. (2012) Camptothecins in tumor homing via an RGD sequence mimetic.. Bioorg Med Chem Lett, 22 (20): (6509-6512). [PMID:22959246] [10.1016/j.bmcl.2012.07.061]
11. Colombo R, Mingozzi M, Belvisi L, Arosio D, Piarulli U, Carenini N, Perego P, Zaffaroni N, De Cesare M, Castiglioni V, Scanziani E, Gennari C.. (2012) Synthesis and biological evaluation (in vitro and in vivo) of cyclic arginine-glycine-aspartate (RGD) peptidomimetic-paclitaxel conjugates targeting integrin αVβ3.. J Med Chem, 55 (23): (10460-10474). [PMID:23140358] [10.1021/jm301058f]
12. Jiang JK, McCoy JG, Shen M, LeClair CA, Huang W, Negri A, Li J, Blue R, Harrington AW, Naini S, David G, Choi WS, Volpi E, Fernandez J, Babayeva M, Nedelman MA, Filizola M, Coller BS, Thomas CJ.. (2014) A novel class of ion displacement ligands as antagonists of the αIIbβ3 receptor that limit conformational reorganization of the receptor.. Bioorg Med Chem Lett, 24 (4): (1148-1153). [PMID:24461295] [10.1016/j.bmcl.2013.12.122]
13. Tolomelli A, Baiula M, Viola A, Ferrazzano L, Gentilucci L, Dattoli SD, Spampinato S, Juaristi E, Escudero M.. (2015) Dehydro-β-proline Containing α4β1 Integrin Antagonists: Stereochemical Recognition in Ligand-Receptor Interplay.. ACS Med Chem Lett, 6 (6): (701-706). [PMID:26101577] [10.1021/acsmedchemlett.5b00125]
14. Merlino F, Daniele S, La Pietra V, Di Maro S, Di Leva FS, Brancaccio D, Tomassi S, Giuntini S, Cerofolini L, Fragai M, Luchinat C, Reichart F, Cavallini C, Costa B, Piccarducci R, Taliani S, Da Settimo F, Martini C, Kessler H, Novellino E, Marinelli L.. (2018) Simultaneous Targeting of RGD-Integrins and Dual Murine Double Minute Proteins in Glioblastoma Multiforme.. J Med Chem, 61 (11): (4791-4809). [PMID:29775303] [10.1021/acs.jmedchem.8b00004]
15. Karakus OO, Godugu K, Rajabi M, Mousa SA.. (2020) Dual Targeting of Norepinephrine Transporter (NET) Function and Thyrointegrin αvβ3 Receptors in the Treatment of Neuroblastoma.. J Med Chem, 63 (14): (7653-7662). [PMID:32571015] [10.1021/acs.jmedchem.0c00537]
16. Suzuki, S S and 6 more authors.. (1986) cDNA and amino acid sequences of the cell adhesion protein receptor recognizing vitronectin reveal a transmembrane domain and homologies with other adhesion protein receptors.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:2430295]
17. Suzuki, S S and 5 more authors.. (1987) Amino acid sequence of the vitronectin receptor alpha subunit and comparative expression of adhesion receptor mRNAs.. The Journal of biological chemistry, (15): [PMID:2443500]
18. Cheresh, D A DA, Smith, J W JW, Cooper, H M HM and Quaranta, V V.. (1989) A novel vitronectin receptor integrin (alpha v beta x) is responsible for distinct adhesive properties of carcinoma cells.. Cell, (7): [PMID:2467745]
19. Donahue, J P JP, Sugg, N N and Hawiger, J J.. (1994) The integrin alpha v gene: identification and characterization of the promoter region.. Biochimica et biophysica acta, (13): [PMID:7522056]
20. Agrez, M V MV and 5 more authors.. (1997) Integrin alpha v beta 6 enhances coxsackievirus B1 lytic infection of human colon cancer cells.. Virology, (8): [PMID:9426447]
21. Barillari, G G and 10 more authors.. (1999) The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor.. Blood, (15): [PMID:10397733]
22. Sims, M A MA and 7 more authors.. (2000) Cloning and characterisation of ITGAV, the genomic sequence for human cell adhesion protein (vitronectin) receptor alpha subunit, CD51.. Cytogenetics and cell genetics, [PMID:10965141]
23. Xiong, J P JP and 8 more authors.. (2001) Crystal structure of the extracellular segment of integrin alpha Vbeta3.. Science (New York, N.Y.), (12): [PMID:11546839]
24. Lin, Cristiane G CG and 6 more authors.. (2003) CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family.. The Journal of biological chemistry, (27): [PMID:12695522]
25. Zhang, Hui H, Li, Xiao-Jun XJ, Martin, Daniel B DB and Aebersold, Ruedi R.. (2003) Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.. Nature biotechnology, [PMID:12754519]
26. Bax, Daniel V DV and 7 more authors.. (2003) Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins.. The Journal of biological chemistry, (5): [PMID:12807887]
27. Krokhin, Oleg V OV and 5 more authors.. (2003) Mass spectrometric based mapping of the disulfide bonding patterns of integrin alpha chains.. Biochemistry, (11): [PMID:14596610]
28. Annes, Justin P; Chen, Yan; Munger, John S and Rifkin, Daniel B.. (2004) Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1.. The Journal of cell biology, (7): [PMID:15184403]
29. Williams, Ciğdem H CH and 5 more authors.. (2004) Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9.. Journal of virology, [PMID:15194773]
30. Jovanovic, Jelena J and 7 more authors.. (2007) alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity.. The Journal of biological chemistry, (2): [PMID:17158881]
31. Caswell, Patrick T PT and 12 more authors.. (2007) Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments.. Developmental cell, [PMID:17925226]
32. Garrigues, H Jacques HJ, Rubinchikova, Yelena E YE, Dipersio, C Michael CM and Rose, Timothy M TM.. (2008) Integrin alphaVbeta3 Binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptor.. Journal of virology, [PMID:18045938]
33. Mori, Seiji S and 10 more authors.. (2008) Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling.. The Journal of biological chemistry, (27): [PMID:18441324]
34. Saegusa, Jun J and 8 more authors.. (2008) Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent manner.. The Journal of biological chemistry, (19): [PMID:18635536]
35. Mikelis, Constantinos C, Sfaelou, Evanthia E, Koutsioumpa, Marina M, Kieffer, Nelly N and Papadimitriou, Evangelia E.. (2009) Integrin alpha(v)beta(3) is a pleiotrophin receptor required for pleiotrophin-induced endothelial cell migration through receptor protein tyrosine phosphatase beta/zeta.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, [PMID:19141530]
36. Wollscheid, Bernd B and 7 more authors.. (2009) Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.. Nature biotechnology, [PMID:19349973]
37. Lyle, Cynthia C and McCormick, Frank F.. (2010) Integrin alphavbeta5 is a primary receptor for adenovirus in CAR-negative cells.. Virology journal, (8): [PMID:20615244]
38. Ieguchi, Katsuaki K and 8 more authors.. (2010) Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling.. The Journal of biological chemistry, (8): [PMID:20682778]
39. Wang, Rui R and 5 more authors.. (2012) GARP regulates the bioavailability and activation of TGFβ.. Molecular biology of the cell, [PMID:22278742]
40. Fujita, Masaaki M, Takada, Yoko K YK and Takada, Yoshikazu Y.. (2012) Integrins αvβ3 and α4β1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:23125415]
41. Schmidt, Katja and 6 more authors.. (2013) Integrins modulate the infection efficiency of West Nile virus into cells.. The Journal of general virology, [PMID:23658209]
42. Freeman, Thomas C TC and 8 more authors.. (2013) Identification of novel integrin binding partners for calcium and integrin binding protein 1 (CIB1): structural and thermodynamic basis of CIB1 promiscuity.. Biochemistry, (8): [PMID:24011356]
43. Gianni, Tatiana T, Salvioli, Stefano S, Chesnokova, Liudmila S LS, Hutt-Fletcher, Lindsey M LM and Campadelli-Fiume, Gabriella G.. (2013) αvβ6- and αvβ8-integrins serve as interchangeable receptors for HSV gH/gL to promote endocytosis and activation of membrane fusion.. PLoS pathogens, [PMID:24367260]
44. Cheshenko, Natalia N and 5 more authors.. (2014) Herpes simplex virus type 2 glycoprotein H interacts with integrin αvβ3 to facilitate viral entry and calcium signaling in human genital tract epithelial cells.. Journal of virology, (1): [PMID:24942591]
45. Fujita, Masaaki M and 7 more authors.. (2015) Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrins αvβ3, α4β1, and α5β1.. The Journal of biological chemistry, (2): [PMID:25398877]
46. Hammes, Stephen R and Davis, Paul J.. (2015) Overlapping nongenomic and genomic actions of thyroid hormone and steroids.. Best practice & research. Clinical endocrinology & metabolism, [PMID:26303085]
47. Yu, Jessica J and 5 more authors.. (2017) The CD9, CD81, and CD151 EC2 domains bind to the classical RGD-binding site of integrin αvβ3.. The Biochemical journal, (15): [PMID:27993971]
48. Dong, Xianchi X and 7 more authors.. (2017) Force interacts with macromolecular structure in activation of TGF-β.. Nature, (2): [PMID:28117447]
49. Mori, Seiji S and 10 more authors.. (2017) The integrin-binding defective FGF2 mutants potently suppress FGF2 signalling and angiogenesis.. Bioscience reports, (28): [PMID:28302677]
50. Cedano Prieto, Dora Maria DM and 5 more authors.. (2017) Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling.. PloS one, [PMID:28873464]
51. Takada, Yoko K YK and 5 more authors.. (2017) Direct binding to integrins and loss of disulfide linkage in interleukin-1β (IL-1β) are involved in the agonistic action of IL-1β.. The Journal of biological chemistry, (8): [PMID:29030430]
52. Takada, Yoko K; Yu, Jessica; Shimoda, Michiko and Takada, Yoshikazu.. (2019) Integrin Binding to the Trimeric Interface of CD40L Plays a Critical Role in CD40/CD40L Signaling.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:31331973]
53. Xiuquan Jia, Jiping Ma, Min Wang, Zhongtian Du, Fang Lu, Feng Wang, Jie Xu. (2014) Promoted role of Cu(NO3)2 on aerobic oxidation of 5-hydroxymethylfurfural to 2,5-diformylfuran over VOSO4. APPLIED CATALYSIS A-GENERAL, 482 (231). [10.1016/j.apcata.2014.05.031]

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Abituzumab (anti-ITGAV), Integrin alpha-V/beta-1 抑制剂

库存信息

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库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

技术文档和文章

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引用文献

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