基本信息

产品名称	SGK1 Antibody
别名	糖皮质激素调节激酶1多克隆抗体 \| 糖皮质激素调节激酶1抗体 \| SGK1抗体
英文别名	OTTHUMP00000017247 antibody \| Serine/threonine protein kinase SGK antibody \| Serine/threonine protein kinase Sgk1 antibody \| Serine/threonine-protein kinase Sgk1 antibody \| Serum and glucocorticoid regulated kinase antibody \| Serum/glucocorticoid regulate
规格或纯度	ExactAb™, Validated, Carrier Free, 0.5 mg/mL
宿主种属	兔(Rabbit)
特异性	SGK1
种属反应性	人(Human),小鼠(Mouse)
免疫原	A KLH conjugated synthetic peptide from the human region of human SGK (Ser78) (AA 70-103).
阳性对照	WB: Jurkat, A431 and Hep G2 cell lysates.
偶联	Unconjugated

产品属性

克隆类型	多克隆抗体
Format	Whole IgG
亚型	Rabbit IgG
SDS-PAGE	150 kDa
纯化方法	Protein A purified + Peptide affinity purified
物理外观	Liquid
储存缓冲液	10mM PBS, 0.09% Sodium azide, pH 7.4
防腐剂	0.09% Sodium azide
浓度	0.5 mg/mL
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	4°C 短期储存（1-2 周）。-20°C下长期保存（24个月）。收货后建议分装。避免冷冻/解冻循环。
分子类型	抗体

关联靶点（人）

SGK1 Tchem 丝氨酸/苏氨酸蛋白激酶Sgk1(Serine/threonine-protein kinase Sgk1) (0 活性数据)

点击查看靶蛋白信息： SGK1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Western Blot: SGK1 Antibody (Ab127341)

SGK1 Antibody (Ab127341) - Western Blot
All lanes: SGK1 Antibody (Ab127341) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 51 kDa
Observed band size: 53 kDa
Exposure time: 32.8 s

IF/ICC: SGK1 Antibody (Ab127341)

SGK1 Antibody (Ab127341) - IF/ICC
Immunofluorescent analysis of 4% paraformaldehyde-fixed, 0.1% Triton X-100 permeabilized HeLa (human cervical epithelial adenocarcinoma cell line) cells labeling SGK with SGK1 Antibody (Ab127341) at 1/25 dilution, followed by Dylight® 488-conjugated goat anti-rabbit IgG secondary antibody at 1/200 dilution (green). Immunofluorescence image showing cytoplasm and nucleus staining on HeLa cell line. Cytoplasmic actin is detected with Dylight® 554 Phalloidin at
1/100 dilution (red). The nuclear counter stain is DAPI (blue).

应用

应用名称	稀释比例
WB	1/1000
IF/ICC	1:25

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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找到2个结果

批号(Lot Number)	证书类型	货号
ZJ24F0102443	分析证书	Ab127341
ZJ24F0102442	分析证书	Ab127341

技术文档和文章

免疫肽封闭实验

Categories: 实验方案（Protocols）

探索主题:

多克隆抗体免疫肽封闭特异性结合

Immunopeptide blocking assay

Categories: 实验方案（Protocols）

探索主题:

Immunopeptideblocking PolyclonalAntibody SpecificBinding

Immunopeptide blocking assay

Categories: 实验方案（Protocols）

探索主题:

Immunopeptideblocking PolyclonalAntibody SpecificBinding

免疫荧光染色实验步骤（甲醇通透法）

Categories: 实验方案（Protocols）

探索主题:

冷冻切片免疫荧光染色组织切片甲醇通透 IF

Immunofluorescence Staining Protocol (Methanol permeabilization)

Categories: 实验方案（Protocols）

探索主题:

Frozen section IF Immunofluorescence staining Tissue section Methanol permeability

Immunofluorescence Staining Protocol (Methanol permeabilization)

Categories: 实验方案（Protocols）

探索主题:

Frozen section IF Immunofluorescence staining Tissue section Methanol permeability

引用文献

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90. Waldegger, S S, Barth, P P, Raber, G G and Lang, F F.. (1997) Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume.. Proceedings of the National Academy of Sciences of the United States of America, (29): [PMID:9114008]
91. Waldegger, S S and 8 more authors.. (1998) Genomic organization and chromosomal localization of the human SGK protein kinase gene.. Genomics, (15): [PMID:9722955]
92. Kobayashi, T T and Cohen, P P.. (1999) Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2.. The Biochemical journal, (15): [PMID:10191262]
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94. Lang, F F and 20 more authors.. (2000) Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy.. Proceedings of the National Academy of Sciences of the United States of America, (5): [PMID:10884438]
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96. Brunet, A A and 5 more authors.. (2001) Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a).. Molecular and cellular biology, [PMID:11154281]
97. Hayashi, M M and 6 more authors.. (2001) BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase.. The Journal of biological chemistry, (23): [PMID:11254654]
98. Zhang, B H BH and 5 more authors.. (2001) Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf.. The Journal of biological chemistry, (24): [PMID:11410590]
99. Snyder, Peter M PM, Olson, Diane R DR and Thomas, Brittany C BC.. (2002) Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel.. The Journal of biological chemistry, (4): [PMID:11696533]
100. Gamper, N N and 9 more authors.. (2002) K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK.. Pflugers Archiv : European journal of physiology, [PMID:12397388]
101. Henke, Guido G, Setiawan, Iwan I, Böhmer, Christoph C and Lang, Florian F.. (2002) Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms.. Kidney & blood pressure research, [PMID:12590200]
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104. Boehmer, Christoph C and 6 more authors.. (2003) Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B.. Journal of neurochemistry, [PMID:12911626]
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106. Palmada, M M and 11 more authors.. (2004) Regulation of intestinal phosphate cotransporter NaPi IIb by ubiquitin ligase Nedd4-2 and by serum- and glucocorticoid-dependent kinase 1.. American journal of physiology. Gastrointestinal and liver physiology, [PMID:15044175]
107. Embark, Hamdy M HM and 10 more authors.. (2004) Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases.. Kidney international, [PMID:15496163]
108. Zhou, Ruifeng R and Snyder, Peter M PM.. (2005) Nedd4-2 phosphorylation induces serum and glucocorticoid-regulated kinase (SGK) ubiquitination and degradation.. The Journal of biological chemistry, (11): [PMID:15576372]
109. David, Samuel S and Kalb, Robert G RG.. (2005) Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB.. FEBS letters, (28): [PMID:15733869]
110. Boehmer, Christoph C and 7 more authors.. (2005) Regulation of the excitatory amino acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and SGK3.. Biochemical and biophysical research communications, (8): [PMID:15737648]
111. Palmada, Monica M, Speil, Andreas A, Jeyaraj, Sankarganesh S, Böhmer, Christoph C and Lang, Florian F.. (2005) The serine/threonine kinases SGK1, 3 and PKB stimulate the amino acid transporter ASCT2.. Biochemical and biophysical research communications, (27): [PMID:15845389]
112. Shojaiefard, Manzar M, Christie, David L DL and Lang, Florian F.. (2005) Stimulation of the creatine transporter SLC6A8 by the protein kinases SGK1 and SGK3.. Biochemical and biophysical research communications, (2): [PMID:16036218]
113. Palmada, Monica M and 6 more authors.. (2006) SGK1 kinase upregulates GLUT1 activity and plasma membrane expression.. Diabetes, [PMID:16443776]
114. Loffing, Johannes J, Flores, Sandra Y SY and Staub, Olivier O.. (2006) Sgk kinases and their role in epithelial transport.. Annual review of physiology, [PMID:16460280]
115. Jeyaraj, Sankarganesh S, Boehmer, Christoph C, Lang, Florian F and Palmada, Monica M.. (2007) Role of SGK1 kinase in regulating glucose transport via glucose transporter GLUT4.. Biochemical and biophysical research communications, (11): [PMID:17382906]
116. Arteaga, Maria F MF, Coric, Tatjana T, Straub, Christoph C and Canessa, Cecilia M CM.. (2008) A brain-specific SGK1 splice isoform regulates expression of ASIC1 in neurons.. Proceedings of the National Academy of Sciences of the United States of America, (18): [PMID:18334630]
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溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

浓度

体积

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

体积 1 (V1)

浓度 2 (C2)

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

货号 (SKU)	包装规格	是否现货
Ab127341-10μl	10μl	现货
Ab127341-50μl	50μL	现货
Ab127341-100μl	100μL	期货
Ab127341-1ml	1ml	期货

SGK1 Antibody

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

应用

质检证书（CoA,COO,BSE/TSE 和分析图谱)

技术文档和文章

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器

SGK1 Antibody

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

应用

质检证书（CoA,COO,BSE/TSE 和分析图谱)

技术文档和文章

相关产品

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器