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Recombinant Peroxiredoxin 1/PAG Antibody

Recombinant Peroxiredoxin 1/PAG Antibody

级别和纯度:

见COA

应用:

IF/ICC
WB

宿主种属: 兔(Rabbit)
种属反应性: 人(Human), 大鼠(Rat), 小鼠(Mouse)
亚型: Rabbit IgG
偶联: Unconjugated

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货号 (SKU)	包装规格	是否现货
Ab121313-10μl	10μl	现货
Ab121313-50μl	50μL	现货
Ab121313-100μl	100μL	现货
Ab121313-1ml	1ml	期货

查看相关系列

点击查看靶蛋白信息: PRDX1

Accession#:Q06830 (2) Gene ID:5052 (2) PAG (1) Peroxiredoxin 1 (1) PRDX1 (2)

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基本信息

产品名称	Recombinant Peroxiredoxin 1/PAG Antibody
别名	过氧化还原酶1(PRDX1)抗体 \| Peroxiredoxin 1/PAG抗体 \| 重组过氧化物酶1/PAG抗体 \| 过氧化还原酶1抗体 \| 过氧化还原酶1单克隆抗体 \| 过氧化还原酶1重组单克隆抗体 \| Peroxiredoxin 1抗体 \| Peroxiredoxin 1单克隆抗体 \| Peroxiredoxin 1重组单克隆抗体 \| PAG抗体 \| PAG单克隆抗体 \| PAG重组单克隆抗体 \| PRDX1抗体 \| PRDX1单克隆抗体 \| PRDX1重组单克隆抗体
英文别名	MSP23 \| NKEF-A \| NKEFA \| PAG \| PAGA \| PAGB \| PRX1 \| PRXI \| TDPX2 \| EC 1.11.1 \| EC 1.11.1.15 \| Natural killer cell-enhancing factor A \| natural killer-enhancing factor A \| PAGAMSP23 \| Peroxiredoxin 1 \| peroxiredoxin-1 \| PRDX1 \| proliferation-associated gen
规格或纯度	重组, ExactAb™, 已验证, 高性能, 见COA
生化机理	Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation.
宿主种属	兔(Rabbit)
特异性	Peroxiredoxin 1/PAG
种属反应性	人(Human),大鼠(Rat),小鼠(Mouse)
免疫原	A synthetic peptide derived from human Peroxiredoxin 1/PAG (AA 186-199).
阳性对照	WB: Mouse brain tissue lysate, C6, NIH/3T3, A431, Hep G2, MCF7, K562, A549 and HeLa cell lysates. ICC/IF: HeLa cells.
偶联	Unconjugated

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Rabbit IgG
轻链亚型	kappa
SDS-PAGE	150 kDa
纯化方法	Protein A purified
物理外观	Liquid
储存缓冲液	50mM Tris-Glycine, 150mM NaCl, 40% Glycerol, 0.05% BSA, 0.01% Sodium azide, pH 7.4
防腐剂	0.01% Sodium azide
浓度	见COA
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	4°C 短期储存（1-2 周）。-20°C下长期保存（24个月）。收货后建议分装。避免冷冻/解冻循环。
分子类型	抗体

关联靶点（人）

PRDX1 Tchem 过氧化物酶-1(Peroxiredoxin-1) (0 活性数据)

点击查看靶蛋白信息： PRDX1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Western Blot: Recombinant Peroxiredoxin 1/PAG Antibody (Ab121313)

Recombinant Peroxiredoxin 1/PAG Antibody (Ab121313) - Western Blot
All lanes: Recombinant Peroxiredoxin 1/PAG Antibody (Ab121313) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 22 kDa
Observed band size: 24 kDa
Exposure time: 10.0 s

IF/ICC: Recombinant Peroxiredoxin 1/PAG Antibody (Ab121313)

Recombinant Peroxiredoxin 1/PAG Antibody (Ab121313) - IF/ICC
Immunocytochemistry analysis of Peroxiredoxin 1 (green) in HeLa using Recombinant Peroxiredoxin 1/PAG Antibody (Ab121313), and cells were counterstained with DAPI (blue).

应用

应用名称	稀释比例
WB	1/2000 - 1/10000
IF/ICC	1/20

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到5个结果

批号(Lot Number)	证书类型	货号
ZJ25F0318893	分析证书	Ab121313
ZJ25F0318901	分析证书	Ab121313
ZJ25F0318900	分析证书	Ab121313
ZJ24F0102514	分析证书	Ab121313
ZJ24F0102515	分析证书	Ab121313

技术文档和文章

免疫荧光染色实验步骤（甲醇通透法）

Categories: 实验方案（Protocols）

探索主题:

冷冻切片免疫荧光染色组织切片甲醇通透 IF

Immunofluorescence Staining Protocol (Methanol permeabilization)

Categories: 实验方案（Protocols）

探索主题:

Frozen section IF Immunofluorescence staining Tissue section Methanol permeability

Immunofluorescence Staining Protocol (Methanol permeabilization)

Categories: 实验方案（Protocols）

探索主题:

Frozen section IF Immunofluorescence staining Tissue section Methanol permeability

引用文献

1. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M. (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions.. Science, 325 (5942): (834-40). [PMID:19608861]
2. Francis Impens,Lilliana Radoshevich,Pascale Cossart,David Ribet. (2014-08-13) Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.. Proceedings of the National Academy of Sciences of the United States of America, 111 ((34)): (12432-12437). [PMID:25114211]
3. Zhou X, Liang Z, Li K, Fang W, Tian Y, Luo X, Chen Y, Zhan Z, Zhang T, Liao S, Liu S, Liu Y, Fenical W, Tang L.. (2019) Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.. J Med Chem, 62 (15): (7058-7069). [PMID:31298537] [10.1021/acs.jmedchem.9b00598]
4. Song K,Nho CW,Ha IJ,Kim YS. (2020) Cellular Target Proteome in Breast Cancer Cells of an Oplopane Sesquiterpenoid Isolated from Tussilago farfara.. J Nat Prod, 83 (9.0): (2559-2566). [PMID:32881525] [10.1021/acs.jnatprod.0c00043]
5. Shau, H H, Butterfield, L H LH, Chiu, R R and Kim, A A.. (1994) Cloning and sequence analysis of candidate human natural killer-enhancing factor genes.. Immunogenetics, [PMID:8026862]
6. Prospéri, M T MT, Ferbus, D D, Karczinski, I I and Goubin, G G.. (1993) A human cDNA corresponding to a gene overexpressed during cell proliferation encodes a product sharing homology with amoebic and bacterial proteins.. The Journal of biological chemistry, (25): [PMID:8496166]
7. Chang, Tong-Shin TS and 5 more authors.. (2002) Regulation of peroxiredoxin I activity by Cdc2-mediated phosphorylation.. The Journal of biological chemistry, (12): [PMID:11986303]
8. Wagner, Elsa E and 6 more authors.. (2002) A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress.. The Biochemical journal, (15): [PMID:12059788]
9. Yang, Kap-Seok KS and 6 more authors.. (2002) Inactivation of human peroxiredoxin I during catalysis as the result of the oxidation of the catalytic site cysteine to cysteine-sulfinic acid.. The Journal of biological chemistry, (11): [PMID:12161445]
10. Woo, Hyun Ae HA and 6 more authors.. (2003) Reversing the inactivation of peroxiredoxins caused by cysteine sulfinic acid formation.. Science (New York, N.Y.), (25): [PMID:12714748]
11. Chevallet, Mireille M and 5 more authors.. (2003) Regeneration of peroxiredoxins during recovery after oxidative stress: only some overoxidized peroxiredoxins can be reduced during recovery after oxidative stress.. The Journal of biological chemistry, (26): [PMID:12853451]
12. She, Yi-Min YM and 5 more authors.. (2003) Identification of metal-binding proteins in human hepatoma lines by immobilized metal affinity chromatography and mass spectrometry.. Molecular & cellular proteomics : MCP, [PMID:14534351]
13. Andersen, Jens S JS and 5 more authors.. (2003) Proteomic characterization of the human centrosome by protein correlation profiling.. Nature, (4): [PMID:14654843]
14. Budanov, Andrei V AV, Sablina, Anna A AA, Feinstein, Elena E, Koonin, Eugene V EV and Chumakov, Peter M PM.. (2004) Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD.. Science (New York, N.Y.), (23): [PMID:15105503]
15. Gregory, S G SG and 178 more authors.. (2006) The DNA sequence and biological annotation of human chromosome 1.. Nature, (18): [PMID:16710414]
16. Chi, An A and 16 more authors.. (2006) Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.. Journal of proteome research, [PMID:17081065]
17. Jönsson, Thomas J TJ, Johnson, Lynnette C LC and Lowther, W Todd WT.. (2008) Structure of the sulphiredoxin-peroxiredoxin complex reveals an essential repair embrace.. Nature, (3): [PMID:18172504]
18. Goshima, Naoki N and 54 more authors.. (2008) Human protein factory for converting the transcriptome into an in vitro-expressed proteome,.. Nature methods, [PMID:19054851]
19. Jönsson, Thomas J TJ, Johnson, Lynnette C LC and Lowther, W Todd WT.. (2009) Protein engineering of the quaternary sulfiredoxin.peroxiredoxin enzyme.substrate complex reveals the molecular basis for cysteine sulfinic acid phosphorylation.. The Journal of biological chemistry, (27): [PMID:19812042]
20. Schmidt, Mathias V MV and 19 more authors.. (2011) Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition.. Proceedings of the National Academy of Sciences of the United States of America, (11): [PMID:21969592]
21. Rosenow, Anja A and 6 more authors.. (2012) Resveratrol-induced changes of the human adipocyte secretion profile.. Journal of proteome research, (7): [PMID:22905912]
22. Zhou, Houjiang H and 6 more authors.. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome.. Journal of proteome research, (4): [PMID:23186163]

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Recombinant Peroxiredoxin 1/PAG Antibody

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

应用

质检证书（CoA,COO,BSE/TSE 和分析图谱)

技术文档和文章

相关产品

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器