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Mre11 Mouse mAb

COA COA
    应用:
  • ELISA
  • Flow Cytometry
  • IHC
  • WB
  • 宿主种属: 小鼠(Mouse)
  • 种属反应性: 人(Human), 大鼠(Rat), 小鼠(Mouse), 猴(Monkey)
  • 亚型: Mouse IgG2b
  • 克隆号: 7C8A9
  • 偶联: Unconjugated
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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
Ab115912-10μl
 10μl 现货 Stock Image
Ab115912-50μl
 50μL 现货 Stock Image
Ab115912-100μl
 100μL 现货 Stock Image
Ab115912-1ml
 1ml 期货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
查看相关系列
点击查看靶蛋白信息: MRE11
Accession#:P49959 (2) Gene ID:4361 (2) MRE11 (1) 流式细胞术 (1163)
main product photo

基本信息

产品名称 Mre11 Mouse mAb
别名 鼠Mre11单克隆抗体 | 小鼠Mre11单克隆抗体 | 鼠抗人Mre11抗体 | Mre11单抗 | Mre11抗体 | Mre11单克隆抗体 | Mre11鼠单抗 | 鼠抗Mre11单克隆抗体 | 小鼠抗人Mre11单克隆抗体 | DNA损伤关键蛋白Mre11抗体 | DNA损伤关键蛋白Mre11鼠单克隆抗体 | ATLD抗体 | DNA重组和修复蛋白抗体 | 双链断裂修复蛋白MRE11A抗体 | Mre11小鼠单克隆抗体 | Mre11小鼠单抗
英文别名 AT like diseaseantibody | Ataxia telangiectasia disorder like antibody | ATLD antibody | DNA recombination and repair proteinantibody | Double strand break repair protein MRE11A antibody | Double-strand break repair protein MRE11A antibody | endo/exonucle
规格或纯度 ExactAb™, Validated, Carrier Free, 1.0mg/mL
宿主种属 小鼠(Mouse)
特异性 MRE11
种属反应性 人(Human),大鼠(Rat),小鼠(Mouse),猴(Monkey)
交叉反应 No cross reacted with tag.
免疫原 Purified recombinant fragment of human MRE 11 (AA: 182-582) expressed in E. Coli.
阳性对照 WB: Hela, A431, MCF-7, Jurkat, HepG2, K562, COS-7, PC-12 and NIH/3T3 cell lysate. IHC: Ovarian cancer tissues; Rectal cancer tissues; Mouse testis tissues; Rat testis tissues; Rabbit testis tissues. Flow: Hela cells; K562 cells.
偶联 Unconjugated

产品属性

克隆类型 单克隆抗体
克隆号 7C8A9
Format Whole IgG
亚型 IgG2b
轻链亚型 kappa
SDS-PAGE 150 kDa
纯化方法 Protein G purified
物理外观 Liquid
储存缓冲液 Purified antibody in 1xPBS with 0.05% sodium azide, pH7.4.
防腐剂 0.05% sodium azide.
浓度 1.0mg/mL
储存温度 -20°C储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 交付后，等分并保存在 -20°C 温度下。避免冷冻/解冻循环。
分子类型 抗体

关联靶点（人）

MRE11 Tbio 双链断裂修复蛋白 MRE11(Double-strand break repair protein MRE11) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

Mre11 Mouse mAb (Ab115912) - Western Blot
All lanes: Mre11 Mouse mAb (Ab115912) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab138040) at 1/30000 dilution

Predicted band size: 80.6 kDa
Observed band size: 84.2 kDa

Mre11 Mouse mAb (Ab115912) - Flow Cytometry
Flow cytometric analysis of cell line labeling Mre11 with Mre11 Mouse mAb (Ab115912) (green) compared with a negative control (red).

Mre11 Mouse mAb (Ab115912) - Flow Cytometry
Flow cytometric analysis of K562 cell line labeling Mre11 with Mre11 Mouse mAb (Ab115912) (green) compared with a negative control (red).

Mre11 Mouse mAb (Ab115912) - IHC
Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using Mre11 Mouse mAb (Ab115912) with DAB staining.

Mre11 Mouse mAb (Ab115912) - IHC
Immunohistochemical analysis of paraffin-embedded human rectal cancer tissues using Mre11 Mouse mAb (Ab115912) with DAB staining.

Mre11 Mouse mAb (Ab115912) - IHC
Immunohistochemical analysis of paraffin-embedded Mouse testis tissues using Mre11 Mouse mAb (Ab115912) with DAB staining.

Mre11 Mouse mAb (Ab115912) - IHC
Immunohistochemical analysis of paraffin-embedded Rat testis tissues using Mre11 Mouse mAb (Ab115912) with DAB staining.

Mre11 Mouse mAb (Ab115912) - IHC
Immunohistochemical analysis of paraffin-embedded Rabbit testis tissues using Mre11 Mouse mAb (Ab115912) with DAB staining.

应用

应用名称 稀释比例
IHC

1/200-1/1000

Flow Cytometry

1/200-1/400

ELISA

1/10000

WB

1/500-1/2000.Predicted molecular weight:80.6 kDa.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到3个结果

批号(Lot Number) 证书类型 货号
ZJ24F1012045 分析证书 Ab115912
ZJ23F0800755 分析证书 Ab115912
ZJ23F0800754 分析证书 Ab115912

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引用文献

1. Todd D Taylor,Hideki Noguchi,Yasushi Totoki,Atsushi Toyoda,Yoko Kuroki,Ken Dewar,Christine Lloyd,Takehiko Itoh,Tadayuki Takeda,Dae-Won Kim,Xinwei She,Karen F Barlow,Toby Bloom,Elspeth Bruford,Jean L Chang,Christina A Cuomo,Evan Eichler,Michael G FitzGerald,David B Jaffe,Kurt LaButti,Robert Nicol,Hong-Seog Park,Christopher Seaman,Carrie Sougnez,Xiaoping Yang,Andrew R Zimmer,Michael C Zody,Bruce W Birren,Chad Nusbaum,Asao Fujiyama,Masahira Hattori,Jane Rogers,Eric S Lander,Yoshiyuki Sakaki.  (2006-03-24)  Human chromosome 11 DNA sequence and analysis including novel gene identification..  Nature,  440  ((7083)): (497-500).  [PMID:16554811]
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9. Wang, Y Y and 5 more authors..  (2000)  BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures..  Genes & development,  (15): [PMID:10783165]
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11. Zhu, X D XD, Küster, B B, Mann, M M, Petrini, J H JH and de Lange, T T..  (2000)  Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres..  Nature genetics,  [PMID:10888888]
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15. Heikkinen, K K, Karppinen, S-M SM, Soini, Y Y, Mäkinen, M M and Winqvist, R R..  (2003)  Mutation screening of Mre11 complex genes: indication of RAD50 involvement in breast and ovarian cancer susceptibility..  Journal of medical genetics,  [PMID:14684699]
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19. Bhoumik, Anindita A and 5 more authors..  (2005)  ATM-dependent phosphorylation of ATF2 is required for the DNA damage response..  Molecular cell,  (27): [PMID:15916964]
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21. Bae, J-B JB and 9 more authors..  (2008)  Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links..  Oncogene,  (28): [PMID:18469862]
22. Daub, Henrik H and 9 more authors..  (2008)  Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle..  Molecular cell,  (8): [PMID:18691976]
23. Mayya, Viveka V and 7 more authors..  (2009)  Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions..  Science signaling,  (18): [PMID:19690332]
24. Rigbolt, Kristoffer T G KT and 9 more authors..  (2011)  System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation..  Science signaling,  (15): [PMID:21406692]
25. Bienvenut, Willy V WV and 6 more authors..  (2012)  Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-α-acetylation features..  Molecular & cellular proteomics : MCP,  [PMID:22223895]
26. Chaki, Moumita M and 72 more authors..  (2012)  Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling..  Cell,  (3): [PMID:22863007]
27. Zhou, Houjiang H and 6 more authors..  (2013)  Toward a comprehensive characterization of a human cancer cell phosphoproteome..  Journal of proteome research,  (4): [PMID:23186163]
28. Lee, Kyung Yong KY and 6 more authors..  (2015)  MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex..  Nature communications,  (28): [PMID:26215093]
29. Broderick, Ronan R and 7 more authors..  (2016)  EXD2 promotes homologous recombination by facilitating DNA end resection..  Nature cell biology,  [PMID:26807646]
30. Staples, Christopher J CJ and 12 more authors..  (2016)  MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response..  Cell reports,  (6): [PMID:27568553]
31. Daddacha, Waaqo W and 27 more authors..  (2017)  SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination..  Cell reports,  (22): [PMID:28834754]
32. Coquel, Flavie F and 20 more authors..  (2018)  SAMHD1 acts at stalled replication forks to prevent interferon induction..  Nature,  [PMID:29670289]
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