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单克隆抗体
Fibrinogen beta chain Mouse mAb

Fibrinogen beta chain Mouse mAb

级别和纯度:

见COA

应用:

宿主种属: 小鼠(Mouse)
种属反应性: 人(Human)
亚型: Mouse IgG2b
克隆号: 2#
偶联: Unconjugated

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货号 (SKU)	包装规格	是否现货
Ab103488-10μl	10μl	现货
Ab103488-50μl	50μL	现货
Ab103488-100μl	100μL	期货
Ab103488-1ml	1ml	期货

查看相关系列

点击查看靶蛋白信息: FGB

Accession#:P02675 (1) FGB (1) Fibrinogen beta chain (1) Gene ID:2244 (1)

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基本信息

产品名称	Fibrinogen beta chain Mouse mAb
别名	纤维蛋白原β(FGB)单克隆抗体 \| Fibrinogen beta chain抗体 \| 纤维蛋白原β链小鼠单克隆抗体 \| 纤维蛋白原β链小鼠单抗
英文别名	HEL-S-78p \| Factor I \| Fib2 \| fibrinogen alpha chain \| Fibrinogen \| fibrinogen, A alpha polypeptide \| MGC119422 \| MGC119423 \| MGC119425 \| Beta fibrinogen antibody \| Epididymis Secretory Sperm Binding Protein Li 78p antibody \| FGB antibody \| FIBB_HUMAN ant
规格或纯度	无载体, ExactAb™, 无叠氮钠, 已验证, 高性能, 见COA
宿主种属	小鼠(Mouse)
特异性	Fibrinogen beta chain
种属反应性	人(Human)
免疫原	Recombinant FGB expressed in E.coli (AA 45-491).
阳性对照	WB: Human serum and Hep G2 lysates. IHC: Human kidney, liver and placenta tissues.
偶联	Unconjugated

产品属性

克隆类型	单克隆抗体
克隆号	2#
Format	Whole IgG
亚型	Mouse IgG2b
轻链亚型	kappa
SDS-PAGE	150 kDa
纯化方法	Protein A + Protein G purified
物理外观	Liquid
储存缓冲液	10mM PBS, 50% Glycerol, 0.05% Proclin 300, pH 7.4
防腐剂	0.05% Proclin 300
浓度	见COA
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	4℃ 短期储存（1-2 周）。-20℃长期保存（24 个月）。收货后建议分装。避免冷冻/解冻循环。
分子类型	抗体

关联靶点（人）

FGB Tbio 纤维蛋白原β链(Fibrinogen beta chain) (0 活性数据)

点击查看靶蛋白信息： FGB

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Western Blot: Fibrinogen beta chain Mouse mAb (Ab103488)

Fibrinogen beta chain Mouse mAb (Ab103488) - Western Blot
All lanes: Fibrinogen beta chain Mouse mAb (Ab103488) at 1/3000 dilution
Samples: Lysates at 20 µL per lane
Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab138040) at 1/20000 dilution

Predicted band size: 56 kDa
Observed band size: 52 kDa
Exposure time: 76.1 s

Western Blot: Fibrinogen beta chain Mouse mAb (Ab103488)

Fibrinogen beta chain Mouse mAb (Ab103488) - Western Blot
All lanes: Fibrinogen beta chain Mouse mAb (Ab103488) at 1/3000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab138040) at 1/20000 dilution

Predicted band size: 56 kDa
Observed band size: 47 kDa
Exposure time: 100.0 s

IHC: Fibrinogen beta chain Mouse mAb (Ab103488)

Fibrinogen beta chain Mouse mAb (Ab103488) - IHC
DAB staining on IHC
Samples: Human Kidney Tissue
Primary Ab: 10 µg/mL Fibrinogen beta chain Mouse mAb (Ab103488)
Second Ab: 2 µg/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody.

IHC: Fibrinogen beta chain Mouse mAb (Ab103488)

Fibrinogen beta chain Mouse mAb (Ab103488) - IHC
DAB staining on IHC
Samples: Human Liver Tissue
Primary Ab: 10 µg/mL Fibrinogen beta chain Mouse mAb (Ab103488)
Second Ab: 2 µg/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody.

IHC: Fibrinogen beta chain Mouse mAb (Ab103488)

Fibrinogen beta chain Mouse mAb (Ab103488) - IHC
DAB staining on IHC
Samples: Human Placenta Tissue
Primary Ab: 10 µg/mL Fibrinogen beta chain Mouse mAb (Ab103488)
Second Ab: 2 µg/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody.

应用

应用名称	稀释比例
IHC	5-20 µg/mL
WB	0.01-2 µg/mL

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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技术文档和文章

叠氮化钠去除实验

Categories: 实验方案（Protocols）

探索主题:

重组抗体叠氮化钠去除抗体纯化葡聚糖凝胶G-25 无叠氮化钠抗体

Sodium Azide Removal Protocol

Categories: 实验方案（Protocols）

探索主题:

Recombinant antibody Sodium Azide Removal Antibody Purification Sephadex G-25 Sodium Azide-Free Antibody

引用文献

1. Watt, K W KW, Takagi, T T and Doolittle, R F RF.. (1979) Amino acid sequence of the beta chain of human fibrinogen.. Biochemistry, (9): [PMID:420779]
2. Gårdlund, B B, Hessel, B B, Marguerie, G G, Murano, G G and Blombäck, B B.. (1977) Primary structure of human fibrinogen. Characterization of disulfide-containing cyanogen-bromide fragments.. European journal of biochemistry, (1): [PMID:891553]
3. Blombäck, B B, Hessel, B B and Hogg, D D.. (1976) Disulfide bridges in nh2 -terminal part of human fibrinogen.. Thrombosis research, [PMID:936108]
4. Koopman, J J and 6 more authors.. (1992) Abnormal fibrinogens IJmuiden (B beta Arg14----Cys) and Nijmegen (B beta Arg44----Cys) form disulfide-linked fibrinogen-albumin complexes.. Proceedings of the National Academy of Sciences of the United States of America, (15): [PMID:1565641]
5. Koopman, J J, Haverkate, F F, Lord, S T ST, Grimbergen, J J and Mannucci, P M PM.. (1992) Molecular basis of fibrinogen Naples associated with defective thrombin binding and thrombophilia. Homozygous substitution of B beta 68 Ala----Thr.. The Journal of clinical investigation, [PMID:1634610]
6. Yoshida, N N and 7 more authors.. (1991) A new congenital abnormal fibrinogen Ise characterized by the replacement of B beta glycine-15 by cysteine.. Blood, (1): [PMID:2018836]
7. Chung, D W DW, Harris, J E JE and Davie, E W EW.. (1990) Nucleotide sequences of the three genes coding for human fibrinogen.. Advances in experimental medicine and biology, [PMID:2102623]
8. Huber, P P and 5 more authors.. (1987) Characterization of the 5'-flanking region for the human fibrinogen beta gene.. Nucleic acids research, (25): [PMID:3029722]
9. Liu, C Y CY, Koehn, J A JA and Morgan, F J FJ.. (1985) Characterization of fibrinogen New York 1. A dysfunctional fibrinogen with a deletion of B beta(9-72) corresponding exactly to exon 2 of the gene.. The Journal of biological chemistry, (10): [PMID:3156856]
10. Schmelzer, C H CH, Ebert, R F RF and Bell, W R WR.. (1988) A polymorphism at B beta 448 of fibrinogen identified during structural studies of fibrinogen Baltimore II.. Thrombosis research, (15): [PMID:3194892]
11. and Doolittle, R F RF.. (1984) Fibrinogen and fibrin.. Annual review of biochemistry, [PMID:6383194]
12. Henschen, A A, Lottspeich, F F, Kehl, M M and Southan, C C.. (1983) Covalent structure of fibrinogen.. Annals of the New York Academy of Sciences, (27): [PMID:6575689]
13. Chung, D W DW, Rixon, M W MW, Que, B G BG and Davie, E W EW.. (1983) Cloning of fibrinogen genes and their cDNA.. Annals of the New York Academy of Sciences, (27): [PMID:6575700]
14. Chung, D W DW, Que, B G BG, Rixon, M W MW, Mace, M M and Davie, E W EW.. (1983) Characterization of complementary deoxyribonucleic acid and genomic deoxyribonucleic acid for the beta chain of human fibrinogen.. Biochemistry, (21): [PMID:6688356]
15. Tran, H H and 5 more authors.. (1995) The interaction of fibulin-1 with fibrinogen. A potential role in hemostasis and thrombosis.. The Journal of biological chemistry, (18): [PMID:7642629]
16. Spraggon, G G, Everse, S J SJ and Doolittle, R F RF.. (1997) Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin.. Nature, (2): [PMID:9333233]
17. Everse, S J SJ, Spraggon, G G, Veerapandian, L L, Riley, M M and Doolittle, R F RF.. (1998) Crystal structure of fragment double-D from human fibrin with two different bound ligands.. Biochemistry, (16): [PMID:9628725]
18. Everse, S J SJ, Spraggon, G G, Veerapandian, L L and Doolittle, R F RF.. (1999) Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide.. Biochemistry, (9): [PMID:10074346]
19. Cargill, M M and 17 more authors.. (1999) Characterization of single-nucleotide polymorphisms in coding regions of human genes.. Nature genetics, [PMID:10391209]
20. Duga, S S and 7 more authors.. (2000) Missense mutations in the human beta fibrinogen gene cause congenital afibrinogenemia by impairing fibrinogen secretion.. Blood, (15): [PMID:10666208]
21. Lounes, K C KC and 5 more authors.. (2001) The impaired polymerization of fibrinogen Longmont (Bbeta166Arg-->Cys) is not improved by removal of disulfide-linked dimers from a mixture of dimers and cysteine-linked monomers.. Blood, (1): [PMID:11468164]
22. Gevaert, Kris K and 6 more authors.. (2003) Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.. Nature biotechnology, [PMID:12665801]
23. Lewandrowski, Urs U, Moebius, Jan J, Walter, Ulrich U and Sickmann, Albert A.. (2006) Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.. Molecular & cellular proteomics : MCP, [PMID:16263699]
24. Liu, Tao T and 6 more authors.. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.. Journal of proteome research, [PMID:16335952]
25. Asselta, Rosanna R and 10 more authors.. (2015) Clinical and molecular characterisation of 21 patients affected by quantitative fibrinogen deficiency.. Thrombosis and haemostasis, [PMID:25427968]
26. Palta, Sanjeev; Saroa, Richa and Palta, Anshu.. (2014) Overview of the coagulation system.. Indian journal of anaesthesia, [PMID:25535411]
27. Thomas R Burkard,Melanie Planyavsky,Ines Kaupe,Florian P Breitwieser,Tilmann Bürckstümmer,Keiryn L Bennett,Giulio Superti-Furga,Jacques Colinge. (2011-01-29) Initial characterization of the human central proteome.. BMC systems biology, 5 (17-17). [PMID:21269460]

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Fibrinogen beta chain Mouse mAb

库存信息

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库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

应用

质检证书（CoA,COO,BSE/TSE 和分析图谱)

技术文档和文章

相关产品

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

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