1916 Citations
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Basic Description
| Synonyms | TRIS | Triladyl | Tris-hydroxymethyl-aminomethan [German] | Trometamole | NSC65434 | Trometamolum | TROMETHAMINE (II) | (tris(hydroxymethyl)aminomethane) | THAM-E | tris-amine | 1,1,1-tris(hydroxymethyl)methanamine | TROMETHAMINE | Trometamol | 2-Amino-2- |
|---|---|
| Specifications & Purity | PharmPure™, USP, Ph.Eur., for cell culture, ≥99.9%(T) |
| Storage Temp | Room temperature,Argon charged |
| Shipped In | Normal |
| Grade | for cell culture, Ph.Eur., PharmPure™, USP |
| Product Description |
Application： Tris(hydroxymethyl)aminomethane is used as buffers in biochemistry and molecular biology laboratories. It is used as a primary standard to standardize acid solutions for chemical analysis. It finds application in cell membranes to increase its permeability. As an alternative to sodium bicarbonate, it used in the treatment of metabolic acidosis. |
Taxonomic Classification
Taxonomy Tree
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Kingdom
Organic compounds
-
Superclass
Organic nitrogen compounds
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Class
Organonitrogen compounds
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Subclass
Amines
- Level5 Alkanolamines
- Level6 1,2-aminoalcohols
- Level5 Alkanolamines
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Subclass
Amines
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Class
Organonitrogen compounds
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Superclass
Organic nitrogen compounds
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic nitrogen compounds |
| Class | Organonitrogen compounds |
| Subclass | Amines |
| Intermediate Tree Nodes | Alkanolamines |
| Direct Parent | 1,2-aminoalcohols |
| Alternative Parents | Primary alcohols Organopnictogen compounds Monoalkylamines Hydrocarbon derivatives |
| Molecular Framework | Aliphatic acyclic compounds |
| Substituents | 1,2-aminoalcohol - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Primary amine - Primary alcohol - Organooxygen compound - Primary aliphatic amine - Alcohol - Aliphatic acyclic compound |
| Description | This compound belongs to the class of organic compounds known as 1,2-aminoalcohols. These are organic compounds containing an alkyl chain with an amine group bound to the C1 atom and an alcohol group bound to the C2 atom. |
| External Descriptors | a small molecule |
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Associated Targets(Human)
PDE5A
Tclin
Phosphodiesterase 5A (5113 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
EGFR
Tclin
Epidermal growth factor receptor erbB1 (33727 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CA2
Tclin
Carbonic anhydrase II (17698 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ESR1
Tclin
Estrogen receptor alpha (17718 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
HMGCR
Tclin
HMG-CoA reductase (2475 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
NR3C1
Tclin
Glucocorticoid receptor (14987 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
INSR
Tclin
Insulin receptor (5558 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
PGR
Tclin
Progesterone receptor (8562 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ADRB2
Tclin
Beta-2 adrenergic receptor (11824 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CHRM2
Tclin
Muscarinic acetylcholine receptor M2 (10671 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ADRB1
Tclin
Beta-1 adrenergic receptor (6630 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
HTR1A
Tclin
Serotonin 1a (5-HT1a) receptor (14969 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ADRA2A
Tclin
Alpha-2a adrenergic receptor (9450 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
AR
Tclin
Androgen Receptor (11781 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CHRM1
Tclin
Muscarinic acetylcholine receptor M1 (12690 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ACE
Tclin
Angiotensin-converting enzyme (1423 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
DRD2
Tclin
Dopamine D2 receptor (23596 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MAOA
Tclin
Monoamine oxidase A (11911 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CNR1
Tclin
Cannabinoid CB1 receptor (20913 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
DRD1
Tclin
Dopamine D1 receptor (9720 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
DRD4
Tchem
Dopamine D4 receptor (7907 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ACHE
Tclin
Acetylcholinesterase (18204 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
PTGS1
Tclin
Cyclooxygenase-1 (9233 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
SLC6A2
Tclin
Norepinephrine transporter (10102 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
HRH2
Tclin
Histamine H2 receptor (5428 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ADRA1D
Tclin
Alpha-1d adrenergic receptor (4171 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
HTR1B
Tclin
Serotonin 1b (5-HT1b) receptor (2801 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
HTR2A
Tclin
Serotonin 2a (5-HT2a) receptor (14758 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
HTR2C
Tclin
Serotonin 2c (5-HT2c) receptor (11471 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ADORA1
Tclin
Adenosine A1 receptor (17603 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CALCR
Tclin
Calcitonin receptor (2215 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
SLC6A4
Tclin
Serotonin transporter (12625 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ADRA1A
Tclin
Alpha-1a adrenergic receptor (8359 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
PTGS2
Tclin
Cyclooxygenase-2 (13999 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
HRH1
Tclin
Histamine H1 receptor (7573 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ADRA1B
Tclin
Alpha-1b adrenergic receptor (2912 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
OPRM1
Tclin
Mu opioid receptor (19785 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
DRD3
Tclin
Dopamine D3 receptor (14368 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
AVPR1A
Tclin
Vasopressin V1a receptor (5412 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
OPRD1
Tclin
Delta opioid receptor (15096 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
OPRK1
Tclin
Kappa opioid receptor (16155 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
SLC6A3
Tclin
Dopamine transporter (10535 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
KCNH2
Tclin
HERG (29587 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
HTR4
Tclin
Serotonin 4 (5-HT4) receptor (2068 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ESR2
Tclin
Estrogen receptor beta (9272 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CYSLTR1
Tclin
Cysteinyl leukotriene receptor 1 (2118 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ERBB2
Tclin
Receptor protein-tyrosine kinase erbB-2 (7851 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CHRM4
Tclin
Muscarinic acetylcholine receptor M4 (6041 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CHRM5
Tclin
Muscarinic acetylcholine receptor M5 (4677 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ADRA2B
Tclin
Alpha-2b adrenergic receptor (4412 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Associated Targets(non-human)
Agtr2
Angiotensin II type 2 (AT-2) receptor (803 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Mc4r
Melanocortin receptor 4 (1205 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Ltc4s
Leukotriene C4 synthase (1 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Sigmar1
Sigma opioid receptor (160 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Npy1r
Neuropeptide Y receptor type 1 (8 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Cckar
Cholecystokinin A receptor (90 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Nos2
Nitric oxide synthase, inducible (3573 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Mapk1
MAP kinase ERK2 (650 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Hdac6
Histone deacetylase 6 (222 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Mmp9
Matrix metalloproteinase 9 (38 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Spinacia oleracea (250 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Rattus norvegicus (775804 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Luciferin 4-monooxygenase (66902 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
rep
Replicase polyprotein 1ab (378 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Glra2
Glycine receptor (1745 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Names and Identifiers
| Pubchem Sid | 488180081 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488180081 |
| IUPAC Name | 2-amino-2-(hydroxymethyl)propane-1,3-diol |
| INCHI | InChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2 |
| InChIKey | LENZDBCJOHFCAS-UHFFFAOYSA-N |
| Smiles | C(C(CO)(CO)N)O |
| Isomeric SMILES | C(C(CO)(CO)N)O |
| WGK Germany | 2 |
| RTECS | TY2900000 |
| Molecular Weight | 121.14 |
| Beilstein | 741883 |
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 E2528596 |
Certificate of Analysis | May 17, 2025 | T110598 |
| E2528595 |
Certificate of Analysis | May 17, 2025 | T110598 |
| D2508639 |
Certificate of Analysis | Mar 17, 2025 | T110598 |
| D2508622 |
Certificate of Analysis | Mar 17, 2025 | T110598 |
| C2504342 |
Certificate of Analysis | Jan 14, 2025 | T110598 |
| B2506656 |
Certificate of Analysis | Jan 14, 2025 | T110598 |
| B2506695 |
Certificate of Analysis | Jan 14, 2025 | T110598 |
| B2506664 |
Certificate of Analysis | Jan 14, 2025 | T110598 |
| B2506783 |
Certificate of Analysis | Jan 14, 2025 | T110598 |
| L2404609 |
Certificate of Analysis | Oct 24, 2024 | T110598 |
| K2401540 |
Certificate of Analysis | Oct 24, 2024 | T110598 |
| I2411418 |
Certificate of Analysis | Aug 31, 2024 | T110598 |
| I2411421 |
Certificate of Analysis | Aug 31, 2024 | T110598 |
| I2411419 |
Certificate of Analysis | Aug 31, 2024 | T110598 |
| E2424088 |
Certificate of Analysis | May 15, 2024 | T110598 |
| H2419094 |
Certificate of Analysis | May 15, 2024 | T110598 |
| F2412371 |
Certificate of Analysis | May 15, 2024 | T110598 |
| F2412372 |
Certificate of Analysis | May 15, 2024 | T110598 |
| C2429674 |
Certificate of Analysis | Apr 01, 2024 | T110598 |
| C2428095 |
Certificate of Analysis | Mar 15, 2024 | T110598 |
| C2428094 |
Certificate of Analysis | Mar 15, 2024 | T110598 |
| B2421328 |
Certificate of Analysis | Jan 30, 2024 | T110598 |
| B2421332 |
Certificate of Analysis | Jan 26, 2024 | T110598 |
| A2403300 |
Certificate of Analysis | Dec 23, 2023 | T110598 |
| A2403301 |
Certificate of Analysis | Dec 23, 2023 | T110598 |
| K2307167 |
Certificate of Analysis | Oct 25, 2023 | T110598 |
| G2324170 |
Certificate of Analysis | Jul 12, 2023 | T110598 |
| E2329866 |
Certificate of Analysis | Apr 07, 2023 | T110598 |
| E2329884 |
Certificate of Analysis | Apr 07, 2023 | T110598 |
| B2324809 |
Certificate of Analysis | Feb 07, 2023 | T110598 |
| B2324835 |
Certificate of Analysis | Feb 07, 2023 | T110598 |
| B2324839 |
Certificate of Analysis | Feb 07, 2023 | T110598 |
| L2228066 |
Certificate of Analysis | Dec 06, 2022 | T110598 |
| L2228053 |
Certificate of Analysis | Dec 06, 2022 | T110598 |
| L2228087 |
Certificate of Analysis | Dec 06, 2022 | T110598 |
| H2206050 |
Certificate of Analysis | Jul 11, 2022 | T110598 |
| H2206048 |
Certificate of Analysis | Jul 11, 2022 | T110598 |
| H2206047 |
Certificate of Analysis | Jul 11, 2022 | T110598 |
| H2206049 |
Certificate of Analysis | Jul 11, 2022 | T110598 |
| H2312231 |
Certificate of Analysis | Jul 11, 2022 | T110598 |
| F2206474 |
Certificate of Analysis | Apr 29, 2022 | T110598 |
| F2206473 |
Certificate of Analysis | Apr 29, 2022 | T110598 |
| A2331485 |
Certificate of Analysis | Apr 29, 2022 | T110598 |
| C2224296 |
Certificate of Analysis | Mar 05, 2022 | T110598 |
| B2218546 |
Certificate of Analysis | Jan 26, 2022 | T110598 |
| B2218512 |
Certificate of Analysis | Jan 26, 2022 | T110598 |
| B2218541 |
Certificate of Analysis | Jan 26, 2022 | T110598 |
Show more⌵
Chemical and Physical Properties
| Solubility | Slightly soluble in acetone, ethanol, methanol, and dimethylformamide; Insoluble in ether and chloroform |
|---|---|
| Sensitivity | Moisture sensitive. |
| Boil Point(°C) | 219-220 °C/10 mmHg (lit.) |
| Melt Point(°C) | 167-173 °C |
| Molecular Weight | 121.140 g/mol |
| XLogP3 | -2.900 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 3 |
| Exact Mass | 121.074 Da |
| Monoisotopic Mass | 121.074 Da |
| Topological Polar Surface Area | 86.700 Ų |
| Heavy Atom Count | 8 |
| Formal Charge | 0 |
| Complexity | 54.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
Alternative Products
-
Tris(hydroxymethyl)aminomethane (Tris base)Starting at $29.90
-
Tris(hydroxymethyl)aminomethane (Tris base)
Starting at $13.90
-
Tris(hydroxymethyl)aminomethane
Starting at $136.90
-
Tris(hydroxymethyl)aminomethane
Starting at $137.90
-
Tris base
Starting at $39.90
-
Tris(hydroxymethyl)aminomethane (TRIS, Trometamol)
Starting at $68.90
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