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Tris(hydroxymethyl)aminomethane - ACS, ≥99.8%, high purity , CAS No.77-86-1

1910 Citations COA COA
    Grade & Purity:
  • ACS
    •
  • ≥99.8%
In stock
Item Number
T110600
Grouped product items
SKU Size
Availability
 Price Qty
T110600-25g
25g
≥10
$13.90
T110600-100g
100g
≥10
$22.90
T110600-500g
500g
3
$149.90
T110600-12×500g
12×500g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,499.90
Wish List
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Biochemical Assay Reagents (928)

Basic Description

Synonyms Triladyl | Tris-hydroxymethyl-aminomethan [German] | Trometamole | NSC65434 | Trometamolum | TROMETHAMINE (II) | CAS-77-86-1 | (tris(hydroxymethyl)aminomethane) | THAM-E | tris-amine | 1,1,1-tris(hydroxymethyl)methanamine | 2-Amino-2-hydroxymethyl-1,3-pro
Specifications & Purity ACS, ≥99.8%
Shipped In Normal
Grade ACS

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic nitrogen compounds
Class Organonitrogen compounds
Subclass Amines
Intermediate Tree Nodes Alkanolamines
Direct Parent 1,2-aminoalcohols
Alternative Parents Primary alcohols  Organopnictogen compounds  Monoalkylamines  Hydrocarbon derivatives  
Molecular Framework Aliphatic acyclic compounds
Substituents 1,2-aminoalcohol - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Primary amine - Primary alcohol - Organooxygen compound - Primary aliphatic amine - Alcohol - Aliphatic acyclic compound
Description This compound belongs to the class of organic compounds known as 1,2-aminoalcohols. These are organic compounds containing an alkyl chain with an amine group bound to the C1 atom and an alcohol group bound to the C2 atom.
External Descriptors a small molecule

Associated Targets(Human)

PDE5A Tclin Phosphodiesterase 5A (5113 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA2 Tclin Carbonic anhydrase II (17698 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HMGCR Tclin HMG-CoA reductase (2475 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
INSR Tclin Insulin receptor (5558 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACE Tclin Angiotensin-converting enzyme (1423 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD4 Tchem Dopamine D4 receptor (7907 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA1D Tclin Alpha-1d adrenergic receptor (4171 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CALCR Tclin Calcitonin receptor (2215 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA1B Tclin Alpha-1b adrenergic receptor (2912 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR4 Tclin Serotonin 4 (5-HT4) receptor (2068 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ESR2 Tclin Estrogen receptor beta (9272 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYSLTR1 Tclin Cysteinyl leukotriene receptor 1 (2118 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM4 Tclin Muscarinic acetylcholine receptor M4 (6041 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM5 Tclin Muscarinic acetylcholine receptor M5 (4677 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA2B Tclin Alpha-2b adrenergic receptor (4412 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ltc4s Leukotriene C4 synthase (1 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Sigmar1 Sigma opioid receptor (160 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cckar Cholecystokinin A receptor (90 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Nos2 Nitric oxide synthase, inducible (3573 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Spinacia oleracea (250 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Luciferin 4-monooxygenase (66902 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Glra2 Glycine receptor (1745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 2-amino-2-(hydroxymethyl)propane-1,3-diol
INCHI InChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
InChIKey LENZDBCJOHFCAS-UHFFFAOYSA-N
Smiles C(C(CO)(CO)N)O
Isomeric SMILES C(C(CO)(CO)N)O
WGK Germany 2
RTECS TY2900000
Molecular Weight 121.14
Beilstein 741883

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

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60 results found

Lot Number Certificate Type Date Item
E2528584 Certificate of Analysis Jun 04, 2025 T110600
E2528581 Certificate of Analysis Jun 04, 2025 T110600
E2528601 Certificate of Analysis Jun 04, 2025 T110600
B2506696 Certificate of Analysis Apr 30, 2025 T110600
D2508626 Certificate of Analysis Apr 21, 2025 T110600
C2524452 Certificate of Analysis Mar 29, 2025 T110600
B2506672 Certificate of Analysis Feb 10, 2025 T110600
B2506671 Certificate of Analysis Feb 10, 2025 T110600
L2404518 Certificate of Analysis Dec 09, 2024 T110600
L2404519 Certificate of Analysis Dec 09, 2024 T110600
L2404517 Certificate of Analysis Dec 09, 2024 T110600
K2401538 Certificate of Analysis Nov 13, 2024 T110600
I2411403 Certificate of Analysis Sep 24, 2024 T110600
F2412385 Certificate of Analysis Jun 15, 2024 T110600
F2412379 Certificate of Analysis Jun 15, 2024 T110600
F2412381 Certificate of Analysis Jun 15, 2024 T110600
E2424093 Certificate of Analysis May 27, 2024 T110600
E2424091 Certificate of Analysis May 27, 2024 T110600
E2424092 Certificate of Analysis May 27, 2024 T110600
C2428101 Certificate of Analysis Apr 11, 2024 T110600
C2428103 Certificate of Analysis Apr 11, 2024 T110600
C2428102 Certificate of Analysis Apr 11, 2024 T110600
B2421323 Certificate of Analysis Feb 23, 2024 T110600
B2421324 Certificate of Analysis Feb 23, 2024 T110600
B2421315 Certificate of Analysis Feb 23, 2024 T110600
B2421314 Certificate of Analysis Feb 23, 2024 T110600
A2303337 Certificate of Analysis Jan 20, 2024 T110600
A2403336 Certificate of Analysis Jan 20, 2024 T110600
A2403339 Certificate of Analysis Jan 20, 2024 T110600
A2403337 Certificate of Analysis Jan 20, 2024 T110600
L2319101 Certificate of Analysis Dec 27, 2023 T110600
K2307119 Certificate of Analysis Nov 17, 2023 T110600
K2307113 Certificate of Analysis Nov 17, 2023 T110600
L1925015 Certificate of Analysis Oct 23, 2023 T110600
I2314052 Certificate of Analysis Sep 18, 2023 T110600
H2321721 Certificate of Analysis Sep 02, 2023 T110600
G2327307 Certificate of Analysis Aug 11, 2023 T110600
G2327320 Certificate of Analysis Aug 11, 2023 T110600
G2324186 Certificate of Analysis Aug 02, 2023 T110600
E2329872 Certificate of Analysis May 17, 2023 T110600
E23081181 Certificate of Analysis May 17, 2023 T110600
L2228068 Certificate of Analysis Dec 30, 2022 T110600
L2228065 Certificate of Analysis Dec 30, 2022 T110600
L2228076 Certificate of Analysis Dec 30, 2022 T110600
L2228067 Certificate of Analysis Dec 30, 2022 T110600
J2227701 Certificate of Analysis Oct 31, 2022 T110600
J2227714 Certificate of Analysis Oct 29, 2022 T110600
J2227705 Certificate of Analysis Oct 29, 2022 T110600
H2206058 Certificate of Analysis Aug 12, 2022 T110600
H2206056 Certificate of Analysis Aug 11, 2022 T110600
H2206057 Certificate of Analysis Aug 11, 2022 T110600
H2206059 Certificate of Analysis Apr 01, 2022 T110600
F2206398 Certificate of Analysis Apr 01, 2022 T110600
C2224302 Certificate of Analysis Apr 01, 2022 T110600
F2206401 Certificate of Analysis Apr 01, 2022 T110600
C2224305 Certificate of Analysis Apr 01, 2022 T110600
B2218558 Certificate of Analysis Feb 22, 2022 T110600
F2206400 Certificate of Analysis Feb 22, 2022 T110600
B2218559 Certificate of Analysis Feb 22, 2022 T110600
B2218547 Certificate of Analysis Feb 22, 2022 T110600

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Chemical and Physical Properties

Sensitivity Moisture sensitive.
Boil Point(°C) 219-220 °C/10 mmHg (lit.)
Melt Point(°C) 167-173 °C
Molecular Weight 121.140 g/mol
XLogP3 -2.900
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 3
Exact Mass 121.074 Da
Monoisotopic Mass 121.074 Da
Topological Polar Surface Area 86.700 Ų
Heavy Atom Count 8
Formal Charge 0
Complexity 54.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

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