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Transferrin Receptor/CD71 Mouse mAb - Primary antibody, specific to Transferrin Receptor/CD71, Mouse IgG2a

    Application:
  • Animal Model
  • Flow Cytometry
  • Functional Assay
  • IHC
  • Host species: Mouse
  • Reactive species: Mouse,Rat
  • Isotype: Mouse IgG2a
  • Clone Number: OX-26
  • Conjugation: Unconjugated
In stock
Item Number
Ab132247
Grouped product items
SKU Size
Availability
Price Qty
Ab132247-10μg
10μg
5
$29.90
Ab132247-50μg
50μg
2
$79.90
Ab132247-100μg
100μg
1
$119.90
Ab132247-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$699.90

mAb (OX-26); Mouse anti Rat/Mouse Transferrin Receptor/CD71 Antibody; Flow, IHC, Targeted drug delivery to the brain; Unconjugated

Basic Description

Product Name Transferrin Receptor/CD71 Mouse mAb - Primary antibody, specific to Transferrin Receptor/CD71, Mouse IgG2a
Synonyms Trfr | CD71 antigen | CD71 | CD71TRFR | p90 | T9 | TfR (Transferrin R) | TfR (TransferrinR) | TfR | TFR1 | TFRC | TR | transferrin receptor (p90, CD71) | transferrin receptor protein 1 | TRFR | CD 71 antibody | CD71 antibody | CD71 antigen antibody | IMD4
Specifications & Purity Carrier Free, Azide Free, Validated, ≥95%(SDS-PAGE), See COA
Host species Mouse
Specificity Transferrin Receptor/CD71
Immunogen PHA-activated PVG rat lymph node cells
Conjugation Unconjugated
Grade Azide Free, Carrier Free, Validated
Product Description

Mouse anti Rat/Mouse Transferrin Receptor/CD71 Antibody, Monoclonal (OX-26), could be used for Flow, IHC, Targeted drug delivery to the brain and so on.
Application
Flow: Use at an assay dependent concentration.
IHC: Use at an assay dependent concentration.
Targeted drug delivery to the brain: Use at an assay dependent concentration.
Protein Function
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).
(Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.

Product Properties

Isotype Mouse IgG2a
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at 2-8°C,Do not freeze
Shipped In Wet ice
Stability And Storage Shipped at 4°C. Store at 4°C long term (12 months). Do not freeze. Upon receipt, it is recommended to aliquot.

Images

Transferrin Receptor/CD71 Mouse mAb (Ab132247) - Flow Cytometry
Flow Cytometry analysis of 2.5 μg/mL Con A stimulated rat spleen cells (24h) labelling Transferrin Receptor/CD71 with Transferrin Receptor/CD71 Mouse mAb (Ab132247) conjugated with biotin (right panel) at 1.0 μg/mL for 1 hour at 4°C, compared with Mouse IgG Isotype Control Antibody (Biotin) (Ab170221) (left panel) and detected with SA-PE (rp156150).

Transferrin Receptor/CD71 Mouse mAb (Ab132247) - Flow Cytometry
Flow Cytometry analysis of 2.5 μg/mL Con A stimulated rat spleen cells (24h) labelling Transferrin Receptor/CD71 (red) with Transferrin Receptor/CD71 Mouse mAb (Ab132247) conjugated with biotin at 1.0 μg/mL for 1 hour at 4°C, and detected with SA-PE (rp156150). Blue - Mouse IgG Isotype Control Antibody (Biotin) (Ab170221). Black - Unlabelled control, cells without incubation with primary antibody.

Application

Application Dilution info
IHC

Use at an assay dependent concentration.

Flow Cytometry

Use at an assay dependent concentration.

Targeted drug delivery to the brain

Use at an assay dependent concentration.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Solution Calculators

Reviews

Customer Reviews

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