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Teclistamab (anti-CD3&BCMA) - Primary antibody, specific to CD3E & TNFRSF17, Human IgG4SP, BINDING AGENT of T cell surface glycoprotein CD3 binding agent, BINDING AGENT of T cell surface glycoprotein CD3 binding agent

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG4SP
  • Conjugation: Unconjugated
In stock
Item Number
Ab175669
Grouped product items
SKU Size
Availability
Price Qty
Ab175669-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$239.90
Ab175669-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,189.90
Ab175669-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,999.90
Ab175669-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$4,999.90

Purity≥90% (SDS-PAGE&SEC-HPLC); Endotoxin Level<1.0 EU/mg; Human IgG4SP; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Teclistamab (anti-CD3&BCMA) - Primary antibody, specific to CD3E & TNFRSF17, Human IgG4SP, BINDING AGENT of T cell surface glycoprotein CD3 binding agent
Synonyms CD3 epsilon antibody | CD3e antibody | CD3e antigen antibody | CD3e antigen epsilon polypeptide (TiT3 complex) antibody | CD3E antigen epsilon polypeptide antibody | CD3E antigen, epsilon subunit antibody | CD3e molecule epsilon antibody | CD3e molecule,
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥90%(SDS-PAGE&SEC-HPLC), See COA
Biochemical and Physiological Mechanisms CD3: The CD3 complex mediates signal transduction. BCMA: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
Host species Human
Specificity CD3E & TNFRSF17
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type BINDING AGENT
Mechanism of action BINDING AGENT of T cell surface glycoprotein CD3 binding agent
Product Description

Teclistamab (anti-CD3 & BCMA) is a human bispecific antibody to BCMA and CD3 that recognizes BCMA on target cells and CD3 on T cells and induces T cell-mediated cytotoxicity leading to T cell activation and subsequent target cell lysis. Teclistamab (anti-CD3 & BCMA) can be used in studies of diseases related to multiple myeloma (MM).

Product Properties

Isotype Human IgG4SP
Light Chain Type lambdaC2
SDS-PAGE 143.64 kDa
Purification Method Protein A purified
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS 2119595-80-9

Associated Targets(Human)

CD3E Tclin T-cell surface glycoprotein CD3 epsilon chain (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
TNFRSF17 Tclin Tumor necrosis factor receptor superfamily member 17 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Images

Teclistamab (anti-CD3&BCMA) (Ab175669) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD3&BCMA with Teclistamab (anti-CD3&BCMA) (Ab175669) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).

Teclistamab (anti-CD3&BCMA) (Ab175669) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD3&BCMA (red) with Teclistamab (anti-CD3&BCMA) (Ab175669) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.

Teclistamab (anti-CD3&BCMA) (Ab175669) - ELISA
Immobilized Recombinant Human CD3 protein (rp175910) at 1.0 μg/mL can bind Teclistamab (anti-CD3&BCMA) (Ab175669) with the EC50 of 99.33 ng/mL.

Teclistamab (anti-CD3&BCMA) (Ab175669) - ELISA
Immobilized Recombinant Human BCMA/TNFRSF17 protein (rp169554) at 1.0 μg/mL can bind Teclistamab (anti-CD3&BCMA) (Ab175669) with the EC50 of 6.582 ng/mL.

Teclistamab (anti-CD3&BCMA) (Ab175669) - SEC
The purity of Teclistamab (anti-CD3&BCMA) (Ab175669) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Solution Calculators

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