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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab175669-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$239.90
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Ab175669-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$1,189.90
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Ab175669-5mg
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5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$2,999.90
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Ab175669-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$4,999.90
|
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Purity≥90% (SDS-PAGE&SEC-HPLC); Endotoxin Level<1.0 EU/mg; Human IgG4SP; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Unconjugated
| Product Name | Teclistamab (anti-CD3&BCMA) - Primary antibody, specific to CD3E & TNFRSF17, Human IgG4SP, BINDING AGENT of T cell surface glycoprotein CD3 binding agent |
|---|---|
| Synonyms | CD3 epsilon antibody | CD3e antibody | CD3e antigen antibody | CD3e antigen epsilon polypeptide (TiT3 complex) antibody | CD3E antigen epsilon polypeptide antibody | CD3E antigen, epsilon subunit antibody | CD3e molecule epsilon antibody | CD3e molecule, |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥90%(SDS-PAGE&SEC-HPLC), See COA |
| Biochemical and Physiological Mechanisms | CD3: The CD3 complex mediates signal transduction. BCMA: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. |
| Host species | Human |
| Specificity | CD3E & TNFRSF17 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | BINDING AGENT |
| Mechanism of action | BINDING AGENT of T cell surface glycoprotein CD3 binding agent |
| Product Description |
Teclistamab (anti-CD3 & BCMA) is a human bispecific antibody to BCMA and CD3 that recognizes BCMA on target cells and CD3 on T cells and induces T cell-mediated cytotoxicity leading to T cell activation and subsequent target cell lysis. Teclistamab (anti-CD3 & BCMA) can be used in studies of diseases related to multiple myeloma (MM).
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| Isotype | Human IgG4SP |
|---|---|
| Light Chain Type | lambdaC2 |
| SDS-PAGE | 143.64 kDa |
| Purification Method | Protein A purified |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS | 2119595-80-9 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Teclistamab (anti-CD3&BCMA) (Ab175669) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD3&BCMA with Teclistamab (anti-CD3&BCMA) (Ab175669) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).
Teclistamab (anti-CD3&BCMA) (Ab175669) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD3&BCMA (red) with Teclistamab (anti-CD3&BCMA) (Ab175669) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.
Teclistamab (anti-CD3&BCMA) (Ab175669) - ELISA
Immobilized Recombinant Human CD3 protein (rp175910) at 1.0 μg/mL can bind Teclistamab (anti-CD3&BCMA) (Ab175669) with the EC50 of 99.33 ng/mL.
Teclistamab (anti-CD3&BCMA) (Ab175669) - ELISA
Immobilized Recombinant Human BCMA/TNFRSF17 protein (rp169554) at 1.0 μg/mL can bind Teclistamab (anti-CD3&BCMA) (Ab175669) with the EC50 of 6.582 ng/mL.
Teclistamab (anti-CD3&BCMA) (Ab175669) - SEC
The purity of Teclistamab (anti-CD3&BCMA) (Ab175669) is more than 95% verified by HPLC.