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Ongericimab (anti-PCSK9) - Primary antibody, specific to PCSK9, Human IgG4SP-Opti, INHIBITOR of Subtilisin/kexin type 9 inhibitor, INHIBITOR of Subtilisin/kexin type 9 inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG4SP-Opti
  • Conjugation: Unconjugated
In stock
Item Number
Ab182886
Grouped product items
SKU Size
Availability
Price Qty
Ab182886-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$109.90
Ab182886-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$519.90
Ab182886-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,399.90
Ab182886-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,239.90

Purity≥95% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG4SP-Opti; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Ongericimab (anti-PCSK9) - Primary antibody, specific to PCSK9, Human IgG4SP-Opti, INHIBITOR of Subtilisin/kexin type 9 inhibitor
Synonyms Convertase subtilisin/kexin type 9 preproprotein antibody | FH3 antibody | HCHOLA3 antibody | Hypercholesterolemia autosomal dominant 3 antibody | LDLCQ1 antibody | NARC 1 antibody | NARC-1 antibody | NARC1 antibody | Neural apoptosis regulated convertase
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Biochemical and Physiological Mechanisms May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis. Post-translational: The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage
Host species Human
Specificity PCSK9
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of Subtilisin/kexin type 9 inhibitor
Product Description

Ongericimab (anti-PCSK9) is a humanized anti-PCSK9 monoclonal antibody. Ongericimab (anti-PCSK9) has lipid-lowering efficacy. Ongericimab (anti-PCSK9) can be used in research of hypercholesteremia and hyperlipidemia.

Product Properties

Isotype Human IgG4SP-Opti
Light Chain Type kappa
SDS-PAGE 144.44 kDa
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 2145096-91-7

Associated Targets(Human)

PCSK9 Tclin Proprotein convertase subtilisin/kexin type 9 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
PCSK9 Tclin Subtilisin/kexin type 9 (362 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Ongericimab (anti-PCSK9) (Ab182886) - ELISA
Immobilized Ongericimab (anti-PCSK9) (Ab182886) at 1.0 μg/mL can bind Recombinant Human PCSK9 protein (rp170397) with the EC50 of 674.7 ng/mL.

Ongericimab (anti-PCSK9) (Ab182886) - SEC
The purity of Ongericimab (anti-PCSK9) (Ab182886) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Alternative Products

Solution Calculators

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