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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab182886-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$109.90
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Ab182886-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$519.90
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|
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Ab182886-5mg
|
5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,399.90
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Ab182886-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$2,239.90
|
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Purity≥95% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG4SP-Opti; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Ongericimab (anti-PCSK9) - Primary antibody, specific to PCSK9, Human IgG4SP-Opti, INHIBITOR of Subtilisin/kexin type 9 inhibitor |
|---|---|
| Synonyms | Convertase subtilisin/kexin type 9 preproprotein antibody | FH3 antibody | HCHOLA3 antibody | Hypercholesterolemia autosomal dominant 3 antibody | LDLCQ1 antibody | NARC 1 antibody | NARC-1 antibody | NARC1 antibody | Neural apoptosis regulated convertase |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Biochemical and Physiological Mechanisms | May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis. Post-translational: The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage |
| Host species | Human |
| Specificity | PCSK9 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | INHIBITOR of Subtilisin/kexin type 9 inhibitor |
| Product Description |
Ongericimab (anti-PCSK9) is a humanized anti-PCSK9 monoclonal antibody. Ongericimab (anti-PCSK9) has lipid-lowering efficacy. Ongericimab (anti-PCSK9) can be used in research of hypercholesteremia and hyperlipidemia. |
| Isotype | Human IgG4SP-Opti |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 144.44 kDa |
| Purification Method | Protein A purified |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 2145096-91-7 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Ongericimab (anti-PCSK9) (Ab182886) - ELISA
Immobilized Ongericimab (anti-PCSK9) (Ab182886) at 1.0 μg/mL can bind Recombinant Human PCSK9 protein (rp170397) with the EC50 of 674.7 ng/mL.
Ongericimab (anti-PCSK9) (Ab182886) - SEC
The purity of Ongericimab (anti-PCSK9) (Ab182886) is more than 95% verified by HPLC.
Starting at $109.90
Starting at $109.90
Starting at $109.90
Starting at $109.90
Starting at $109.90
Starting at $109.90