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Evolocumab(anti-PCSK9) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to PCSK9, >95%, high purity, Human IgG2, Antibody of proprotein convertase subtilisin/kexin type 9, Antibody of proprotein convertase subtilisin/kexin type 9

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human,Mouse
  • Isotype: Human IgG2
  • Conjugation: Unconjugated
In stock
Item Number
Ab169287
Grouped product items
SKU Size
Availability
Price Qty
Ab169287-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$89.90
Ab169287-1mg
1mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$447.90
Ab169287-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,137.90
Ab169287-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,857.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Evolocumab(anti-PCSK9) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to PCSK9, >95%, high purity, Human IgG2, Antibody of proprotein convertase subtilisin/kexin type 9
Synonyms Convertase subtilisin/kexin type 9 preproprotein antibody | FH3 antibody | HCHOLA3 antibody | Hypercholesterolemia autosomal dominant 3 antibody | LDLCQ1 antibody | NARC 1 antibody | NARC-1 antibody | NARC1 antibody | Neural apoptosis regulated convertase
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity PCSK9
Application ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action Antibody of proprotein convertase subtilisin/kexin type 9
Product Description

Evolocumab is a human monoclonal antibody that inhibits PCSK9. Evolocumab binds to the circulating PCSK9 protein, inhibiting it from binding to the LDLR. Evolocumab can be used for the research of hypercholesterolemia and atherosclerotic cardiovascular diseases.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Antibody Type Primary antibody
Clonality Recombinant
Isotype Human IgG2
Light Chain Type lambda
SDS-PAGE 28.7 kDa (Light Chain) & 51.4 kDa (Heavy Chain), under reducing conditions; 175.8 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Source CHO supernatant
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1256937-27-5

Associated Targets(Human)

PCSK9 Tclin Proprotein convertase subtilisin/kexin type 9 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
PCSK9 Tclin Subtilisin/kexin type 9 (362 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Evolocumab (anti- PCSK9) (Ab169287) - SEC
The purity of Evolocumab (anti- PCSK9) (Ab169287) is more than 95% verified by HPLC.

Evolocumab (anti-PCSK9) (Ab169287) - ELISA
Immobilized hu-PCSK9-chis at 2 μg/mL can bind Evolocumab (anti-PCSK9) (Ab169287) with the EC₅₀ of 14.03 ng/mL.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ23F1001266 Certificate of Analysis Oct 13, 2023 Ab169287
ZJ23F1001265 Certificate of Analysis Oct 13, 2023 Ab169287

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