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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab169287-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$89.90
|
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Ab169287-1mg
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1mg |
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
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$447.90
|
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Ab169287-5mg
|
5mg |
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
|
$1,137.90
|
|
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Ab169287-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,857.90
|
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Evolocumab(anti-PCSK9) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to PCSK9, >95%, high purity, Human IgG2, Antibody of proprotein convertase subtilisin/kexin type 9 |
|---|---|
| Synonyms | Convertase subtilisin/kexin type 9 preproprotein antibody | FH3 antibody | HCHOLA3 antibody | Hypercholesterolemia autosomal dominant 3 antibody | LDLCQ1 antibody | NARC 1 antibody | NARC-1 antibody | NARC1 antibody | Neural apoptosis regulated convertase |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | PCSK9 |
| Application | ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | Antibody of proprotein convertase subtilisin/kexin type 9 |
| Product Description |
Evolocumab is a human monoclonal antibody that inhibits PCSK9. Evolocumab binds to the circulating PCSK9 protein, inhibiting it from binding to the LDLR. Evolocumab can be used for the research of hypercholesterolemia and atherosclerotic cardiovascular diseases. |
| Antibody Type | Primary antibody |
|---|---|
| Clonality | Recombinant |
| Isotype | Human IgG2 |
| Light Chain Type | lambda |
| SDS-PAGE | 28.7 kDa (Light Chain) & 51.4 kDa (Heavy Chain), under reducing conditions; 175.8 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Source | CHO supernatant |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 1256937-27-5 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Evolocumab (anti- PCSK9) (Ab169287) - SEC
The purity of Evolocumab (anti- PCSK9) (Ab169287) is more than 95% verified by HPLC.
Evolocumab (anti-PCSK9) (Ab169287) - ELISA
Immobilized hu-PCSK9-chis at 2 μg/mL can bind Evolocumab (anti-PCSK9) (Ab169287) with the EC₅₀ of 14.03 ng/mL.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Oct 13, 2023 | Ab169287 | |
| Certificate of Analysis | Oct 13, 2023 | Ab169287 |
Starting at $109.90
Starting at $109.90
Starting at $109.90
Starting at $109.90
Starting at $109.90
Starting at $109.90
Starting at $109.90