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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab209824-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$109.90
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Ab209824-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$509.90
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|
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Ab209824-5mg
|
5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,399.90
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Ab209824-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$2,299.90
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Purity≥95% (SDS-PAGE&SEC-HPLC); Endotoxin Level<1.0 EU/mg; Human IgG1; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Unconjugated
| Product Name | NCI m972 (anti-CD22) - Primary antibody, specific to CD22 |
|---|---|
| Synonyms | B cell receptor CD22 precursor antibody | B lymphocyte cell adhesion molecule antibody | B-cell receptor CD22 antibody | B-lymphocyte cell adhesion molecule antibody | BL CAM antibody | BL-CAM antibody | BLCAM antibody | CD 22 antibody | CD22 antibody | C |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Biochemical and Physiological Mechanisms | Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be ma |
| Host species | Human |
| Specificity | CD22 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Product Description |
NCI m972 (anti-CD22) is a humanized monoclonal antibody targeting CD22, a Siglec family lectin present on B cells. It is a promising novel therapeutics for B-cell acute lymphoblastic leukemia (BCP-ALL). |
| Light Chain Type | kappa |
|---|---|
| SDS-PAGE | 144.3 kDa |
| Purification Method | Protein A purified |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
NCI m972 (anti-CD22) (Ab209824) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD22 with NCI m972 (anti-CD22) (Ab209824) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).
NCI m972 (anti-CD22) (Ab209824) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD22 (red) with NCI m972 (anti-CD22) (Ab209824) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.
NCI m972 (anti-CD22) (Ab209824) - ELISA
Immobilized pE447-P00086-GSV0-C-His at 2.0 μg/mL can bind NCI m972 (anti-CD22) (Ab209824) with the EC50 of 191.5 ng/mL.
NCI m972 (anti-CD22) (Ab209824) - SEC
The purity of NCI m972 (anti-CD22) (Ab209824) is more than 95% verified by HPLC.
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