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MEDI2045 (anti-IL-4Ra) - Primary antibody, specific to IL4R, Human IgG1

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab209762
Grouped product items
SKU Size
Availability
Price Qty
Ab209762-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$109.90
Ab209762-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$509.90
Ab209762-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,399.90
Ab209762-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,299.90

Purity≥95% (SDS-PAGE&SEC-HPLC); Endotoxin Level<1.0 EU/mg; Human IgG1; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name MEDI2045 (anti-IL-4Ra) - Primary antibody, specific to IL4R, Human IgG1
Synonyms CD124 antibody | IL 4R alpha antibody | IL-4 receptor subunit alpha antibody | IL-4-binding protein antibody | IL-4R subunit alpha antibody | IL-4R-alpha antibody | IL-4RA antibody | IL4-BP antibody | Il4r antibody | IL4R nirs variant 1 antibody | IL4RA a
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Biochemical and Physiological Mechanisms Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production
Host species Human
Specificity IL4R
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Product Description

MEDI2045 (anti-IL-4Ra) is a high-affinity human and Cynomolgus cross-reactive antibody that blocks the functional interaction of IL-4 and IL-13 with their obligate receptor, IL-4Ra. MEDI2045 (anti-IL-4Ra) has the potential to treat severe, uncontrolled asthma.

Product Properties

Isotype Human IgG1
Light Chain Type lambda
SDS-PAGE 150 kDa
Purification Method Protein A purified
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

IL4R Tclin Interleukin-4 receptor subunit alpha (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
IL4R Tclin Interleukin-4 receptor subunit alpha (0 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

MEDI2045 (anti-IL-4Ra) (Ab209762) - ELISA
Immobilized Recombinant Human IL-4R alpha protein (rp184044) at 1.0 μg/mL can bind MEDI2045 (anti-IL-4Ra) (Ab209762) with the EC₅₀   of 85.89 ng/mL.

MEDI2045 (anti-IL-4Ra) (Ab209762) - SEC
The purity of MEDI2045 (anti-IL-4Ra) (Ab209762) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Solution Calculators

Reviews

Customer Reviews

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