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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab169296-100μg
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100μg |
10
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$59.90
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Ab169296-1mg
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1mg |
4
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$267.90
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Ab169296-5mg
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5mg |
1
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$837.90
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Ab169296-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$1,317.90
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Dupilumab (anti-IL-4Ra) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to IL-4R, >95%, high purity, Human IgG4SP, Antibody of Interleukin-4 receptor subunit α |
|---|---|
| Synonyms | CD124 antibody | IL 4R alpha antibody | IL-4 receptor subunit alpha antibody | IL-4-binding protein antibody | IL-4R subunit alpha antibody | IL-4R-alpha antibody | IL-4RA antibody | IL4-BP antibody | Il4r antibody | IL4R nirs variant 1 antibody | IL4RA a |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | IL-4R |
| Application | ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | ANTAGONIST |
| Mechanism of action | Antibody of Interleukin-4 receptor subunit α |
| Product Description |
Dupilumab is a fully human mAb to IL-4 receptor α (IL-4Rα) that inhibits both IL-4 and IL-13 signaling, markedly improved moderate-to-severe atopic dermatitis. |
| Antibody Type | Primary antibody |
|---|---|
| Clonality | Recombinant |
| Isotype | Human IgG4SP |
| Light Chain Type | kappa |
| SDS-PAGE | 26.4 kDa (Light Chain) & 52.8 kDa (Heavy Chain), under reducing conditions; 187.4 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Source | CHO supernatant |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 1190264-60-8 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Dupilumab (anti-IL-4Ra) (Ab169296) - Flow Cytometry
HEK293 human embryonic kidney cell line transfected with rhuIL-4R-full length was stained with Dupilumab (anti-IL-4Ra) (Ab169296).
Dupilumab (anti-IL-4Ra) (Ab169296) - SEC
The purity of Dupilumab (anti-IL-4Ra) (Ab169296) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Mar 25, 2024 | Ab169296 | |
| Certificate of Analysis | Mar 25, 2024 | Ab169296 | |
| Certificate of Analysis | Mar 25, 2024 | Ab169296 |
Starting at $59.90
Starting at $109.90