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Lyn Mouse mAb - Primary antibody, specific to LYN, Mouse IgG1

    Application:
  • WB
  • Host species: Mouse
  • Reactive species: Human
  • Isotype: Mouse IgG1
  • Clone Number: 1C8-H3-G6
  • Conjugation: Unconjugated
In stock
Item Number
Ab113790
Grouped product items
SKU Size
Availability
Price Qty
Ab113790-10μl
10μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$66.90
Ab113790-50μl
50μl
1
$189.90
Ab113790-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$299.90
Ab113790-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,699.90

mAb (1C8-H3-G6); Mouse anti Human Lyn Antibody; WB; Unconjugated

Basic Description

Product Name Lyn Mouse mAb - Primary antibody, specific to LYN, Mouse IgG1
Synonyms AA407514antibody | EC 2.7.10.2 antibody | FLJ26625 antibody | Hck 2 antibody | JTK 8 antibody | JTK8 antibody | Lck/Yes related novel protein tyrosine kinase antibody | LYN antibody | LYN proto oncogene, Src family tyrosine kinase antibody | LYN_HUMAN ant
Specifications & Purity ExactAb™, Validated, 1.0 mg/mL
Host species Mouse
Specificity LYN
Immunogen Purified recombinant human Lyn protein fragments expressed in Ecoli (AA 8-238)
Positive Control WB: Ramos, Raji, K562, HeLa and A431 cell lysates.
Conjugation Unconjugated
Grade ExactAb™, Validated
Product Description

Mouse anti Human Lyn Antibody, Monoclonal (1C8-H3-G6), could be used for WB and so on.
Application:
WB: 1/500-1/1000
Protein Function
Down regulates expression of stem cell growth factor receptor (KIT). Acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between proliferation and maturation (By similarity). Acts as a positive regulator of cell movement while negatively regulating adhesion to stromal cells by inhibiting the ICAM-1-binding activity of beta-2 integrins. Acts as the mediator that relays suppressing signals from the chemokine receptor CXCR4 to beta-2 integrin LFA-1 in hematopoietic precursors. Involved in induction of stress-activated protein kinase (SAPK), but not ERK or p38 MAPK, in response to genotoxic agents. Induces SAPK by a MKK7- and MEKK1-dependent mechanism. The LYN -> MEKK1 -> MKK7 -> SAPK pathway is functional in the induction of apoptosis by genotoxic agents.

Product Properties

Isotype Mouse IgG1
SDS-PAGE 150 kDa
Purification Method Protein G purified
Shape Liquid
Concentration 1.0 mg/mL
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

LYN Tclin Tyrosine-protein kinase Lyn (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Lyn Mouse mAb (Ab113790) - Western Blot
All lanes: Lyn Mouse mAb (Ab113790) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab138040) at 1/20000 dilution

Predicted band size: 59 kDa
Observed band size: 55 kDa
Exposure time: 47.5 s

Application

Application Dilution info
WB

1/500-1/1000

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ23F1202190 Certificate of Analysis Dec 28, 2023 Ab113790
ZJ23F1202189 Certificate of Analysis Dec 28, 2023 Ab113790

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