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Ruplizumab (anti-CD40L) - Primary antibody, specific to CD40LG, Human IgG1, INHIBITOR of CD40 ligand inhibitor, INHIBITOR of CD40 ligand inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab183448
Grouped product items
SKU Size
Availability
Price Qty
Ab183448-100μg
100μg
10
$59.90
Ab183448-1mg
1mg
4
$289.90
Ab183448-5mg
5mg
1
$749.90
Ab183448-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,189.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Ruplizumab (anti-CD40L) - Primary antibody, specific to CD40LG, Human IgG1, INHIBITOR of CD40 ligand inhibitor
Synonyms CD154 antibody | CD40 antigen ligand antibody | CD40 ligand antibody | CD40-L antibody | CD40L antibody | CD40L_HUMAN antibody | CD40LG antibody | gp39 antibody | hCD40L antibody | HIGM1 antibody | IGM antibody | IMD3 antibody | soluble form antibody | T
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity CD40LG
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of CD40 ligand inhibitor
Product Description

Ruplizumab (anti-CD40L) is a humanized monoclonal anti-CD40L (TNF Receptor) IgG1κ antibody. Ruplizumab (anti-CD40L) has the potential for systemic lupus erythematosus disease research.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 26.2 kDa (Light Chain) & 51.5 kDa (Heavy Chain), under reducing conditions; 191.6 kDa, under non-reducing conditions.
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 220651-94-5

Associated Targets(Human)

CD40LG Tbio CD40 ligand (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Ruplizumab (anti-CD40L) (Ab183448) - ELISA
Immobilized Recombinant Human CD40 Ligand protein (rp169583) at 2.0 μg/mL can bind Ruplizumab (anti-CD40L) (Ab183448) with the EC50 of 24.77 ng/mL.

Ruplizumab (anti-CD40L) (Ab183448) - Flow Cytometry
pLVX-puro-SYMX10-TNFSF5 (CD40L) - FL - HEK293 cells were stained with Ruplizumab (anti-CD40L) (Ab183448) and negative control protein respectively, washed and then followed by PE and analyzed with the FACS EC50 is 0.23 nM.

Ruplizumab (anti-CD40L) (Ab183448) - SEC
The purity of Ruplizumab (anti-CD40L) (Ab183448) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0708359 Certificate of Analysis Jul 16, 2024 Ab183448
ZJ24F0708358 Certificate of Analysis Jul 16, 2024 Ab183448
ZJ24F0708357 Certificate of Analysis Jul 16, 2024 Ab183448

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