Determine the necessary mass, volume, or concentration for preparing a solution.
This is a demo store. No orders will be fulfilled.
| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
|
Ab183448-100μg
|
100μg |
10
|
$59.90
|
|
|
Ab183448-1mg
|
1mg |
4
|
$289.90
|
|
|
Ab183448-5mg
|
5mg |
1
|
$749.90
|
|
|
Ab183448-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,189.90
|
|
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Ruplizumab (anti-CD40L) - Primary antibody, specific to CD40LG, Human IgG1, INHIBITOR of CD40 ligand inhibitor |
|---|---|
| Synonyms | CD154 antibody | CD40 antigen ligand antibody | CD40 ligand antibody | CD40-L antibody | CD40L antibody | CD40L_HUMAN antibody | CD40LG antibody | gp39 antibody | hCD40L antibody | HIGM1 antibody | IGM antibody | IMD3 antibody | soluble form antibody | T |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | CD40LG |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | INHIBITOR of CD40 ligand inhibitor |
| Product Description |
Ruplizumab (anti-CD40L) is a humanized monoclonal anti-CD40L (TNF Receptor) IgG1κ antibody. Ruplizumab (anti-CD40L) has the potential for systemic lupus erythematosus disease research. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 26.2 kDa (Light Chain) & 51.5 kDa (Heavy Chain), under reducing conditions; 191.6 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 220651-94-5 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Ruplizumab (anti-CD40L) (Ab183448) - ELISA
Immobilized Recombinant Human CD40 Ligand protein (rp169583) at 2.0 μg/mL can bind Ruplizumab (anti-CD40L) (Ab183448) with the EC50 of 24.77 ng/mL.
Ruplizumab (anti-CD40L) (Ab183448) - Flow Cytometry
pLVX-puro-SYMX10-TNFSF5 (CD40L) - FL - HEK293 cells were stained with Ruplizumab (anti-CD40L) (Ab183448) and negative control protein respectively, washed and then followed by PE and analyzed with the FACS EC50 is 0.23 nM.
Ruplizumab (anti-CD40L) (Ab183448) - SEC
The purity of Ruplizumab (anti-CD40L) (Ab183448) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Jul 16, 2024 | Ab183448 | |
| Certificate of Analysis | Jul 16, 2024 | Ab183448 | |
| Certificate of Analysis | Jul 16, 2024 | Ab183448 |
Starting at $59.90
Starting at $69.90
Starting at $119.90
Starting at $49.90
Starting at $49.90