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Dapirolizumab (anti-CD40L) - Primary antibody, specific to CD40LG, Human IgG1

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab191960
Grouped product items
SKU Size
Availability
Price Qty
Ab191960-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$59.90
Ab191960-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$289.90
Ab191960-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$929.90
Ab191960-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,499.90

Purity≥95% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Dapirolizumab (anti-CD40L) - Primary antibody, specific to CD40LG, Human IgG1
Synonyms CD154 antibody | CD40 antigen ligand antibody | CD40L antibody | CD40LG antibody | Gp39 antibody | HIGM1 antibody | Hyper IgM syndrome antibody | IGM antibody | IMD3 antibody | Ly62 antibody | T B cell activating molecule antibody | TBAM antibody | TNF re
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Biochemical and Physiological Mechanisms The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper
Host species Human
Specificity CD40LG
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Product Description

Dapirolizumab (anti-CD40L) is a monoclonal antibodi against CD40 ligand. Dapirolizumab (anti-CD40L) targets CD40L, blocks its interaction with CD40 receptors, and inhibits adaptive immune activation. Dapirolizumab (anti-CD40L) attenuates systemic lupus erythematosus.

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 145 kDa
Purification Method Protein A purified
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

CD40LG Tbio CD40 ligand (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Dapirolizumab (anti-CD40L) (Ab191960) - Flow Cytometry
Flow Cytometry analysis of unstimulated (left) or 500 ng/mL Ionomycin (I139530) and 10 ng/mL PMA (P408905) co-stimulated (right) Jurkat cells labelling CD40L (red) with Dapirolizumab (anti-CD40L) (Ab191960) at 0.1 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Dapirolizumab (anti-CD40L) (Ab191960) - ELISA
Immobilized Recombinant Human CD40 Ligand/TNFSF5 protein (rp189423) at 1.0 μg/mL can bind Dapirolizumab (anti-CD40L) (Ab191960) with the EC₅₀ of 28.88 ng/mL.

Dapirolizumab (anti-CD40L) (Ab191960) - SEC
The purity of Dapirolizumab (anti-CD40L) (Ab191960) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Alternative Products

Solution Calculators

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