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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab191955-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$59.90
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Ab191955-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$289.90
|
|
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Ab191955-5mg
|
5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$719.90
|
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Ab191955-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,139.90
|
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Purity≥95% (SDS-PAGE&SEC-HPLC); Endotoxin Level<1.0 EU/mg; Human IgG1; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Unconjugated
| Product Name | Keliximab (anti-CD4) - Primary antibody, specific to CD4 |
|---|---|
| Synonyms | CD 4 antibody | CD4 (L3T4) antibody | CD4 antibody | CD4 antigen (p55) antibody | CD4 antigen antibody | CD4 molecule antibody | CD4 receptor antibody | CD4+ Lymphocyte deficiency, included antibody | CD4_HUMAN antibody | CD4mut antibody | L3T4 antibody | |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Biochemical and Physiological Mechanisms | Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. Post-translational: Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts |
| Host species | Human |
| Specificity | CD4 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Product Description |
Keliximab (anti-CD4) with a Ki value of 1.0 nM for soluble CD4. Keliximab (anti-CD4) blocks T cell proliferation and inhibits IL-2 production. Keliximab (anti-CD4) can be used for cancer research.
|
| Light Chain Type | lambda |
|---|---|
| SDS-PAGE | 144.12 kDa |
| Purification Method | Protein A purified |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 174722-30-6 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Keliximab (anti-CD4) (Ab191955) - Flow Cytometry
Flow Cytometry analysis of THP-1 cells labelling CD4 (red) with Keliximab (anti-CD4) (Ab191955) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Keliximab (anti-CD4) (Ab191955) - ELISA
Immobilized Recombinant Human CD4/TNFRSF5 protein (rp183577) at 1.0 μg/mL can bind Keliximab (anti-CD4) (Ab191955) with the EC₅₀ of 25.94 ng/mL.
Keliximab (anti-CD4) (Ab191955) - SEC
The purity of Keliximab (anti-CD4) (Ab191955) is more than 95% verified by HPLC.
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